Patents by Inventor Paul Nicklin

Paul Nicklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF TRPC6 FOR TREATING RESPIRATORY CONDITIONS
    Publication number: 20230149393
    Abstract: The invention relates to methods for treating a disorder associated with vascular hyperpermeability and/or conditions arising therefrom, comprising administering to a patient in need thereof a pharmaceutically effective amount of a TRPC6 inhibitor of formula (I), or pharmaceutically acceptable salts thereof, wherein R1 to R7, A, Y and L are as defined herein.
    Type: Application
    Filed: April 14, 2021
    Publication date: May 18, 2023
    Inventors: Thierry BOUYSSOU, Abhya GUPTA, Paul NICKLIN, Nima SOLEYMANLOU
  • Inhibitors of TRPC6
    Patent number: 11485740
    Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts therefore, wherein R1 to R6, A, U, V, W, X, Y, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: November 1, 2022
    Assignees: Boehringer Ingelheim International GmbH, Hydra Biosciences, LLC
    Inventors: Steven Brunette, Jianwen Cui, Michael D. Lowe, Christopher Ronald Sarko, Simon Surprenant, Michael Robert Turner, Xinyuan Wu, Lana Louise Smith Keenan, Thierry Bouyssou, Paul Nicklin
  • SYSTEM, METHOD AND INTERFACE FOR COMMUNICATION AND VIEWING OF MEDICAL IMAGING
    Publication number: 20220044395
    Abstract: A system for processing, communication and viewing of medical imaging study data is configured to process and communicate medical imaging study data for communication between a local system and a client terminal. The systems preferably include a local system, one or more client terminals and an intermediate remote server. The local system may be located within a Virtual Private Network (VPN) and includes a local or site server, a Picture Archiving and Communication System (PACS) and a Radiology Information System (RIS). The local or site server communicates between the PACS and the RIS, and the intermediate remote server that may be outside of the VPN. The local or site server may be configured to perform a lossless image processing method to process, compress and encrypt and communicate medical imaging study data. An interface and associated methods of viewing medical imaging study data are also disclosed.
    Type: Application
    Filed: September 13, 2019
    Publication date: February 10, 2022
    Inventors: Houman EBRAHIMI, Kenny Zhihong HONG, Steven Paul NICKLIN
  • ANTI-ANGPT2 ANTIBODIES
    Publication number: 20200407435
    Abstract: The present invention relates to new anti-angiopoietin 2 (ANGPT2) neutralizing antibodies for therapeutic and diagnostic methods and composition using them.
    Type: Application
    Filed: June 25, 2020
    Publication date: December 31, 2020
    Inventors: Ryan Michael FRYER, Chao ZHENG, Michael DZIEGELEWSKI, Pankaj GUPTA, Thierry BOUYSSOU, Paul NICKLIN
  • INHIBITORS OF TRPC6
    Publication number: 20200399282
    Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts therefore, wherein R1 to R6, A, U, V, W, X, Y, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: February 13, 2019
    Publication date: December 24, 2020
    Inventors: Steven Brunette, Jianwen Cui, Michael D. Lowe, Christopher Ronald Sarko, Simon Surprenant, Michael Robert Turner, Xinyuan Wu, Lana Louise Smith Keenan, Thierry Bouyssou, Paul Nicklin