Patents by Inventor Paul Nicklin

Paul Nicklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OLCEGEPANT FOR TREATING SEPSIS
    Publication number: 20260174762
    Abstract: The present invention relates to the compound for use in a method for treating a patient with a disorder associated with bacterial or fungal severe sepsis, and bacterial or fungal septic shock and conditions arising therefrom, a pharmaceutical composition which contains said compound and its use as medicament for the treatment of bacterial or fungal severe sepsis and bacterial or fungal septic shock and conditions arising therefrom.
    Type: Application
    Filed: November 9, 2023
    Publication date: June 25, 2026
    Inventors: Thierry BOUYSSOU, Paul NICKLIN, Ines Vera Viktoria TRUEBENBACH, Markus ZWICKL
  • TRPC6 INHIBITORY COMPOUNDS FOR TREATING SEPSIS
    Publication number: 20240408087
    Abstract: The present invention relates to compounds of formula (I) for use in methods for of a patient with a disorder associated with bacterial or fungal severe sepsis, and bacterial or fungal septic shock and conditions arising therefrom, wherein the groups Y, A and R1 to R7 are as defined herein, pharmaceutical compositions which contain compounds of this kind and their use as medicaments for the treatment of bacterial or fungal severe sepsis and bacterial or fungal septic shock and conditions arising therefrom.
    Type: Application
    Filed: October 14, 2022
    Publication date: December 12, 2024
    Inventors: Thierry BOUYSSOU, Paul NICKLIN
  • INHIBITORS OF TRPC6 FOR TREATING RESPIRATORY CONDITIONS
    Publication number: 20230149393
    Abstract: The invention relates to methods for treating a disorder associated with vascular hyperpermeability and/or conditions arising therefrom, comprising administering to a patient in need thereof a pharmaceutically effective amount of a TRPC6 inhibitor of formula (I), or pharmaceutically acceptable salts thereof, wherein R1 to R7, A, Y and L are as defined herein.
    Type: Application
    Filed: April 14, 2021
    Publication date: May 18, 2023
    Inventors: Thierry BOUYSSOU, Abhya GUPTA, Paul NICKLIN, Nima SOLEYMANLOU
  • Inhibitors of TRPC6
    Patent number: 11485740
    Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts therefore, wherein R1 to R6, A, U, V, W, X, Y, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: November 1, 2022
    Assignees: Boehringer Ingelheim International GmbH, Hydra Biosciences, LLC
    Inventors: Steven Brunette, Jianwen Cui, Michael D. Lowe, Christopher Ronald Sarko, Simon Surprenant, Michael Robert Turner, Xinyuan Wu, Lana Louise Smith Keenan, Thierry Bouyssou, Paul Nicklin
  • ANTI-ANGPT2 ANTIBODIES
    Publication number: 20200407435
    Abstract: The present invention relates to new anti-angiopoietin 2 (ANGPT2) neutralizing antibodies for therapeutic and diagnostic methods and composition using them.
    Type: Application
    Filed: June 25, 2020
    Publication date: December 31, 2020
    Inventors: Ryan Michael FRYER, Chao ZHENG, Michael DZIEGELEWSKI, Pankaj GUPTA, Thierry BOUYSSOU, Paul NICKLIN
  • INHIBITORS OF TRPC6
    Publication number: 20200399282
    Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts therefore, wherein R1 to R6, A, U, V, W, X, Y, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: February 13, 2019
    Publication date: December 24, 2020
    Inventors: Steven Brunette, Jianwen Cui, Michael D. Lowe, Christopher Ronald Sarko, Simon Surprenant, Michael Robert Turner, Xinyuan Wu, Lana Louise Smith Keenan, Thierry Bouyssou, Paul Nicklin