Patents by Inventor Paul O. Sheppard

Paul O. Sheppard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Zace1: a human metalloenzyme
    Patent number: 6878810
    Abstract: Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin II from angiotensin I, and the inactivation of the vasodilatory peptide bradykinin. Zace1 is a new form of human zinc metallopeptidase, which includes one zinc-dependent catalytic domain containing the motif “HEXXH” and one downstream “EX(I/V)X(D/S)” motif.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: April 12, 2005
    Assignee: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Motilin Homologs
    Patent number: 6838438
    Abstract: The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: January 4, 2005
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Theresa A. Deisher, Paul D. Bishop, Stephen R. Jaspers, Virender M. Labroo
  • Antibodies to mammalian adhesion protease peptides
    Publication number: 20040259163
    Abstract: The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAPP polypeptides.
    Type: Application
    Filed: May 25, 2004
    Publication date: December 23, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Nand Baindur, Paul D. Bishop
  • MOTILIN HOMOLOGS
    Publication number: 20040254345
    Abstract: The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
    Type: Application
    Filed: February 28, 2001
    Publication date: December 16, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Theresa A. Deisher, Paul D. Bishop, Stephen R. Jaspers, Virender M. Labroo
  • Secreted salivary zsig63 polypeptide
    Patent number: 6828419
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig63, a novel secreted salivary protein. The polypeptides, and polynucleotides encoding them, may exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The polynucleotides encoding zsig63, are located on chromosome 4, and can be used to identify a region of the genome associated with human disease states. The present invention also includes antibodies to the zsig63 polypeptides.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: December 7, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: David A. Adler, Paul O. Sheppard
  • Antibodies that bind human Zven1
    Patent number: 6828425
    Abstract: The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: December 7, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Paul D. Bishop
  • Antibodies to growth factor homolog zvegf4
    Publication number: 20040242850
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Application
    Filed: June 25, 2004
    Publication date: December 2, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Teresa Gilbert, Charles E. Hart, Paul O. Sheppard, Debra G. Gilbertson
  • Polynucleotides for mammalian secreted protein, Z1055G2P
    Patent number: 6822082
    Abstract: The present invention provides to polynucleotides and secreted proteins encoded by the polynucleotides. The proteins include a variety of fusion proteins, including fusions comprising a signal peptide selected from the group consisting of signal peptides shown in SEQ ID NO:M, wherein M is an even integer from 2 to 328, operably linked to a second polypeptide. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: November 23, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell
  • Methods of decreasing ZVEGF3 activity
    Patent number: 6814965
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: November 9, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Zeren Gao, Charles E. Hart, Christopher S. Piddington, Paul O. Sheppard, Kimberly E. Shoemaker, Debra G. Gilbertson, James W. West
  • Methods of regulating body weight
    Publication number: 20040208866
    Abstract: The present invention relates to a method of regulating body weight, body mass, fat depositions, and circulating glucose levels, by antagonizing zsig33 peptide by binding it with an antibody.
    Type: Application
    Filed: October 6, 2003
    Publication date: October 21, 2004
    Inventors: Stephen R. Jaspers, Paul O. Sheppard, Paul D. Bishop, Joseph L. Kuijper, Theresa A. Deisher
  • Adipocyte-specific protein homologs
    Patent number: 6803450
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig37 polypeptides.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: October 12, 2004
    Assignee: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Mammalian secretory protein Zsig43
    Publication number: 20040180398
    Abstract: Receptors perform many functions that are essential for the metabolism and differentiation of cells. As such, this class of proteins often provides targets for therapeutically useful drugs. The present invention provides a new human membrane-associated polypeptide, designated “Zsig43.
    Type: Application
    Filed: October 24, 2001
    Publication date: September 16, 2004
    Inventors: Paul O. Sheppard, Si Lok
  • Uses of human Zven proteins and polynucleotides
    Publication number: 20040162238
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal funciton with Zven1 and Zven2 polypeptides.
    Type: Application
    Filed: October 7, 2003
    Publication date: August 19, 2004
    Inventors: Penny J. Thompson, Katherine E. Lewis, Stephen R. Jaspers, Richard M. Garcia, Robert R. West, Susan D. Holderman, Chung Chan, Paul O. Sheppard, Anitra Wolf
  • Uses of human Zven antagonists
    Publication number: 20040156842
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.
    Type: Application
    Filed: October 7, 2003
    Publication date: August 12, 2004
    Inventors: Penny J. Thompson, Paul O. Sheppard
  • Interferon-like protein zcyto21
    Publication number: 20040146988
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-&agr; at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: March 2, 2004
    Publication date: July 29, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell, Brian A. Fox, Teresa Gilbert, Betty A. Haldeman, Francis J. Grant
  • Novel secreted proteins
    Publication number: 20040147722
    Abstract: The present invention provides to polynucleotides and secreted proteins encoded by the polynucleotides. The proteins include and cytokines, growth factors, include fusion proteins operably linked to a second polypeptide. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.
    Type: Application
    Filed: February 12, 2004
    Publication date: July 29, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell, David W. Taft
  • Mammalian adhesion protease peptides
    Patent number: 6762044
    Abstract: The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAPP polypeptides.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: July 13, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Nand Baindur, Paul D. Bishop
  • Human Zven1 proteins
    Patent number: 6756479
    Abstract: The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: June 29, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Paul D. Bishop
  • Mammalian secretory peptide - 9
    Publication number: 20040110927
    Abstract: Novel mammalian secretory polypeptides, polynucleotides encoding the polypeptides (called Zsig9), and related compositions and methods including antibodies and anti-idiotypic antibodies. Overexpression of these proteins is indicative of the presence of cancer. Antibodies and anti-sense nucleotides can be used therapeutically to treat the disease. Furthermore, antibodies to Zsig9 and nucleotide primers and probes can be used to diagnose the presence of tumors.
    Type: Application
    Filed: November 19, 2003
    Publication date: June 10, 2004
    Inventors: Paul O. Sheppard, Laura J. Jelinek
  • Novel FGF homologs
    Publication number: 20040096936
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
    Type: Application
    Filed: October 19, 2001
    Publication date: May 20, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard