Patents by Inventor Paul P. Lee

Paul P. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and apparatus for cell culture array
    Patent number: 10843189
    Abstract: Methods and systems are described for improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: November 24, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul J. Hung, Philip J. Lee, Luke P. Lee
  • DEVICES AND METHODS FOR TISSUE RETRACTION
    Publication number: 20200229690
    Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices that lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstructions for dissection tools. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained bowed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.
    Type: Application
    Filed: April 6, 2020
    Publication date: July 23, 2020
    Inventors: Ryan V. Wales, Paul Smith, Danny S. Lee, Scott E. Brechbiel, Jialiang Wang, Sean P. Fleury
  • Transgenic plants with enhanced agronomic traits
    Publication number: 20200208167
    Abstract: This invention provides recombinant DNA constructs, transgenic plant nuclei and cells with such recombinant DNA construct for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: January 9, 2020
    Publication date: July 2, 2020
    Inventors: Mark Scott Abad, Jeffrey E. Ahrens, Alice Clara Augustine, Erin Bell, Robert J. Bensen, Paolo Castiglioni, Richard Eric Cerny, Shobha Char, Xianfeng Chen, Jaishree M. Chittoor-Vijayanath, Maureen Daley, Jilll Deikman, Molian Deng, Todd DeZwaan, Stephen Duff, Michael D. Edgerton, Bradon J. Fabbri, Jason Fenner, Karen Gabbert, Barry S. Goldman, Deborah J. Hawkins, Steve He, Richard Johnson, Balasulojini Karunanandaa, Garrett J. Lee, Paul Loida, Savitha Madappa, Robert J. Meister, Donald E. Nelson, Anand Pandravada, Obed Patty, Ming Peng, Marie Petracek, Rajani Monnanda Somaiah, Dhanalakshmi Ramachandra, Monica P. Ravanello, Thomas G. Ruff, Rick A Sanders, Beth Savidge, Steven H. Schwartz, Padmini Sudarshana, Jindong Sun, Rebecca L. Thompson-Mize, Virginia Ursin, Dale L. Val, Srikanth Venkatachalayya, Tymagondlu V. Venkatesh, Kammaradi Vidya, K. Vijayalakshmi, Todd C. Weber, Jingrui Wu, Zhidong Xie, Wei Zheng
  • Devices and methods for tissue retraction
    Patent number: 10694934
    Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices that lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstructions for dissection tools. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained bowed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: June 30, 2020
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Ryan V. Wales, Paul Smith, Danny S. Lee, Scott E. Brechbiel, Jialiang Wang, Sean P. Fleury
  • Message synchronization system
    Patent number: 10599513
    Abstract: A method for managing data transfer for a plurality of processors. Transfer messages exchanged between processor units and an external node in an integrity manager located in hardware in communication with the processor units and the external node are received. An exchange of the transfer messages is managed by the processor units with the external node based on a selected mode in mixed integrity modes such that redundantly calculated outputs from the processor units in a high integrity mode match.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: March 24, 2020
    Assignee: The Boeing Company
    Inventors: Wing C. Lee, Sean M. Ramey, Ronald James Koontz, Dick P. Wong, Jackson Chia, Anthony S. Fornabaio, Murali Rangarajan, Clarke Edgar Moore, David Clyde Sharp, Arnold W. Nordsieck, Paul Eugene Denzel
  • Devices and methods for the rapid and accurate detection of analytes
    Patent number: 10585092
    Abstract: Disclosed are field effect transistor-based (FET-based) sensors for the rapid and accurate detection of analytes both in vivo and in vitro. The FET-based sensors can include a substrate, a channel disposed on the substrate, a source electrode and a drain electrode electrically connected to the channel, and a recognition element for an analyte of interest immobilized on the surface of the channel via a linking group. The distance between the recognition element and the channel can be configured such that association of the analyte of interest with the recognition element induces a change in the electrical properties of the channel. In this way, an analyte of interest can be detected by measuring a change in an electrical property of the channel. Also provided are devices, including probes and multi-well plates, incorporating the FET-based sensors.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: March 10, 2020
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Stephen C. Lee, Wu Lu, Leonard J. Brillson, Gregg A. Hadley, Ronald P. Pelletier, Paul R. Berger
  • Instruction processing alignment system
    Patent number: 10528077
    Abstract: A method for synchronizing processor units. An external synchronizer is communicated with to determine whether an undesired amount of skew is present between a first processor unit and a second processor unit in communication with a synchronization system. The first processor unit is selectively directed to perform an action without generating a needed result such that the undesired amount of skew between the first processor unit and the second processor unit is reduced when the undesired amount of skew is present in the first processor unit. The first processor unit and the second processor unit are associated with each other for a high integrity mode in which integrity checks are performed on corresponding messages generated by the first processor unit and the second processor unit.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: January 7, 2020
    Assignee: The Boeing Company
    Inventors: Wing C. Lee, Sean M. Ramey, Ronald James Koontz, Dick P. Wong, Jackson Chia, Anthony S. Fornabaio, Murali Rangarajan, Clarke Edgar Moore, David Clyde Sharp, Arnold W. Nordsieck, Paul Eugene Denzel
  • Methods and devices for micro-isolation, extraction, and/or analysis of microscale components in an array
    Patent number: 10457937
    Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation device described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation device can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation device can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation device can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: October 29, 2019
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF SOUTHERN CALIFORNIA, CURATE BIOSCIENCES LLC
    Inventors: Emil P. Kartalov, Cheng-Chung Lee, Paul Predki
  • Monitoring of equipment associated with a borehole/conduit
    Patent number: 10458224
    Abstract: Monitoring one or more items of equipment associated with a borehole or other conduit. A sensor system includes a vibration sensor for sensing vibrations at one or more sensor locations associated with one or more items of the equipment and/or the borehole or other conduit. A processing system processes the sensor information to determine a characteristic of the operation of the one or more items of equipment and/or the borehole or other conduit.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: October 29, 2019
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: Paul Frederick Cilgrim Dickenson, Gareth P. Lees, Arthur H. Hartog, Cheng-Gang Xie, Paul Simon Hammond, Ashley Bernard Johnson, Gary Martin Oddie, Andrew William Meredith, Franck Bruno Jean Monmont, Theo Cuny
  • WHEELCHAIR APPARATUSES INCLUDING USAGE FEATURES
    Publication number: 20190307619
    Abstract: A powered wheelchair apparatus includes a chair component, a power base component and a wheelchair control system. The wheelchair control system includes a processor and a user input device communicatively coupled to the processor. A display is communicatively coupled to the processor. A memory module is communicatively coupled to the processor that stores logic that, when executed by the processor, causes the system to receive user instructions from the user input device and display a message on the display based on the user instructions. The display is on a back of the chair component.
    Type: Application
    Filed: April 9, 2019
    Publication date: October 10, 2019
    Applicant: Toyota Motor North America, Inc.
    Inventors: Douglas Moore, Christopher P. Lee, Paul Ellsworth Nichols, Thomas Mitchell Dair
  • Systems and methods for wireless authorization at a vending machine
    Patent number: 10380822
    Abstract: Some embodiments are associated with wireless payment or account verification or authorization for purchases made from a vending machine via a customer's mobile device.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: August 13, 2019
    Assignee: Charge Fusion Technologies, LLC
    Inventors: Paul D. Signorelli, Sih Y. Lee, Paul T. Breitenbach, Daniel E. Tedesco, Dean P. Alderucci
  • Message Synchronization System
    Publication number: 20190155681
    Abstract: A method for managing data transfer for a plurality of processors. Transfer messages exchanged between processor units and an external node in an integrity manager located in hardware in communication with the processor units and the external node are received. An exchange of the transfer messages is managed by the processor units with the external node based on a selected mode in mixed integrity modes such that redundantly calculated outputs from the processor units in a high integrity mode match.
    Type: Application
    Filed: November 21, 2017
    Publication date: May 23, 2019
    Inventors: Wing C. Lee, Sean M. Ramey, Ronald James Koontz, Dick P. Wong, Jackson Chia, Anthony S. Fornabaio, Murali Rangarajan, Clarke Edgar Moore, David Clyde Sharp, Arnold W. Nordsieck, Paul Eugene Denzel
  • Instruction Processing Alignment System
    Publication number: 20190155325
    Abstract: A method for synchronizing processor units. An external synchronizer is communicated with to determine whether an undesired amount of skew is present between a first processor unit and a second processor unit in communication with a synchronization system. The first processor unit is selectively directed to perform an action without generating a needed result such that the undesired amount of skew between the first processor unit and the second processor unit is reduced when the undesired amount of skew is present in the first processor unit. The first processor unit and the second processor unit are associated with each other for a high integrity mode in which integrity checks are performed on corresponding messages generated by the first processor unit and the second processor unit.
    Type: Application
    Filed: November 21, 2017
    Publication date: May 23, 2019
    Inventors: Wing C. Lee, Sean M. Ramey, Ronald James Koontz, Dick P. Wong, Jackson Chia, Anthony S. Fornabaio, Murali Rangarajan, Clarke Edgar Moore, David Clyde Sharp, Arnold W. Nordsieck, Paul Eugene Denzel
  • Method of preventing or treating glaucoma
    Patent number: 8415364
    Abstract: The present invention relates, in general, to glaucoma and, in particular, to a method of preventing or treating glaucoma using statins.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: April 9, 2013
    Assignee: Duke University
    Inventors: David L. Epstein, Paul P. Lee, Vasanth Rao
  • Mosaic image collector including an embedded atomic clock
    Patent number: 7773126
    Abstract: An imaging system includes a camera having a lens and a focal planar array (FPA) for capturing at least one image frame having a plurality of sub-image frames. Each sub-image frame includes multiple pixel values corresponding to photonic intensities of the captured image frame. An embedded atomic clock (EAC) is integrated in one single unit with the camera for providing time code data. A multiplexer combines the multiple pixel values of one sub-image frame with the time code data, and an input/output module provides both, the time code data and the multiple pixel values of the sub-image frame as an output data stream.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: August 10, 2010
    Assignee: ITT Manufacturing Enterprises, Inc.
    Inventors: Paul P. Lee, Kenneth R. Gardner, Fred Yacoby
  • Spectral polarimetric image detection and analysis methods and apparatus
    Patent number: 7557918
    Abstract: Apparatus and methods for detecting and analyzing spectral polarimetric images are disclosed. Spectral polarimetric images are detected by selecting spectral bands of light within light received from a light source and capturing polarimetric images of the selected spectral bands of light. Spectral polarimetric images are analyzed by converting spectral polarimetric images to Stokes images and selecting two or more of the Stokes images for analysis.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: July 7, 2009
    Assignee: ITT Manufacturing Enterprises, Inc.
    Inventors: J. Daniel Newman, Paul P. Lee, Eric J. Knappenberger, Rulon Simmons, Andre Dominic Cropper
  • Sensor synchronization using embedded atomic clocks
    Patent number: 7558157
    Abstract: A data acquisition system includes multiple terminal nodes. Each terminal node includes a sensor, an atomic clock and a controller. Each sensor is adapted to sense an external event and transform the external event into an electrical signal. Each atomic clock generates a time reference. Each controller is coupled to the atomic clock and the sensor, and is configured to merge the electrical signal with the time reference and provide a time-stamped data stream to a remote central processor. The remote central processor is configured to organize a respective time-stamped data stream from one terminal node with another respective time-stamped data stream from another terminal node.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: July 7, 2009
    Assignee: ITT Manufacturing Enterprises, Inc.
    Inventors: Kenneth R. Gardner, Fred Yacoby, Paul P. Lee
  • Image sensor pixel for global electronic shuttering
    Patent number: 7129979
    Abstract: A pixel design for CMOS image sensors that has a high frame rate potential and, therefore, provides motion capture capabilities. The pixel is designed for global electronic shuttering so every pixel is exposed simultaneously to images incident upon the pixel array plane. The present invention has the advantages of: (1) Allowing the accommodation of changes in the pixel output groupings for different monochrome output format or CFA patterns with only changes in metal routing layers; (2) allowing true electronic shuttering to image moving scene with all the pixels having the same capture time windows; and (3) providing a symmetric global shutter gate and transfer gate to minimize pixel related fixed pattern noise. The pixel architecture provides for a CMOS based, active pixel image sensor comprising an array of pixels formed in rows and columns, with each of the pixels containing at least one active circuit element.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: October 31, 2006
    Assignee: Eastman Kodak Company
    Inventor: Paul P. Lee
  • Integrated CMOS active pixel digital camera
    Patent number: 6721008
    Abstract: An image sensor device comprising a silicon substrate having a plurality of CMOS circuit formed thereon, including a pixel array having a plurality of rows and a plurality of columns, a row addressing circuit operatively connected to each the pixel array and the timing control circuit, the row addressing circuit having a row bus that provides address lines to each row in the pixel array, a column addressing circuit, a pixel timing circuit, a timing control logic block, a signal processing circuit, and an interface circuit coupled to external computational means for provision of address and control signals to the sensor device, the interface circuit being operatively coupled the timing control logic, the pixel timing circuit, the row addressing circuit and the column addressing circuit.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: April 13, 2004
    Assignee: Eastman Kodak Company
    Inventors: Paul P. Lee, Lawrence J. Bernstein, Robert M. Guidash, Teh-Hsuang Lee
  • Flat-panel light emitting pixel with luminance feedback
    Patent number: 6720942
    Abstract: An image display includes an addressable image display pixel, having a substrate; a light emitter formed on the substrate; a photo-sensor formed on the substrate and optically coupled to the light emitter to detect light emitted by the light emitter to generate a feedback voltage signal in response to light emitted by the light emitter; and, a feedback readout circuit formed on the substrate and responsive to the feedback voltage signal to provide a feedback signal representing the light output of the light emitter, the feedback readout circuit including a transistor amplifier, means for resetting the readout circuit, and a select switch.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: April 13, 2004
    Assignee: Eastman Kodak Company
    Inventors: Paul P. Lee, Ronald S. Cok