Abstract: Methods of making orally available softgels includes pre-wetting a probiotic with an edible oil to produce a wetted supplement, wherein the edible oil is present in a range of 25% to 75% by weight of a total weight of the probiotic and edible oil, heating the wetted supplement to a temperature in a range of 35° C. to 40° C., blending the wetted supplement and a molten chocolate component together to produce a liquid fill material, encapsulating the liquid fill material in a softgel coating to produce an orally available softgel, and cooling the orally available softgel to have a softgel capsule shell comprising 5% to 15% by weight water. The fill material is a solid at room temperature in the cooled orally available softgel.

Abstract: A rotatable nacelle includes an engine inlet configured to receive air and an inlet air management system (IAMS). The IAMS includes a primary inlet configured to selectively allow air to flow into a duct associated with the engine air inlet via the primary inlet and a secondary inlet configured to selectively allow air to flow into the duct associated with the engine air inlet via the secondary inlet. The secondary inlet is configured to receive an air filter.

Abstract: A method of operating an articulatable surgical instrument. The method includes providing a rotary drive motion to a rotary drive member of a surgical end effector and converting the rotary drive motion to an upper axial motion and a lower axial motion at locations that are distal to the articulation joint. The method further includes applying the upper axial motion to an upper portion of a firing member and applying the lower axial motion to a lower portion of the firing member such that the upper axial motion and lower axial motion drives the firing member distally through the surgical end effector from a starting position to an ending position.

Abstract: A wireless transmit receive unit (WTRU) may receive physical uplink control channel (PUCCH) configuration information, SBFD configuration information, and DCI comprising a first PRI. The WTRU may determine that a PUCCH transmission is to be sent. The WTRU may determine, based on a first rule of interpreting the first PRI and the PUCCH configuration information, that a first PUCCH resource indicated by the first PRI is included in at least one frequency resource that is at least partially included in at least one subband for uplink (UL) transmission and one subband for downlink reception indicated by the SBFD configuration information. The WTRU may determine a second PUCCH resource, which may be determined based on a second rule for interpreting the first PRI and the PUCCH configuration information. The second PUCCH resource may be within subbands for UL transmission. The WTRU may transmit the PUCCH transmission using the second frequency resource.

Abstract: A firearm sight mounting plate assembly for a firearm is provided. The firearm sight mounting plate assembly includes a mounting plate. The mounting plate having a first area supporting an iron sight, and the mounting plate having a second area supporting an optic. The first area is different from the second area.

Abstract: A firearm mounting plate assembly is provided. The firearm mounting plate assembly includes a firearm slide with a first side, a second side, and a top side. A recess defined by a first slide wall, a second slide wall, and a recess base surface is disposed on the firearm slide top side. The recess includes a rib, a slot, and an ejector projection. The firearm mounting plate assembly includes a mounting plate with a top surface, a bottom surface, a front side, and a rear side. An ejector notch and a channel is disposed along the bottom surface. The mounting plate includes a stud, and one or more bosses. The mounting plate is configured to secure within the recess of the firearm slide.

Abstract: In an example implementation, a method includes receiving, at a computing device, borrower information and requested financing plan information. Likewise, a method includes outputting at least a portion of the received information to a second computing device and, after receiving an indication of a decision denying the requested financing plan, outputting at least a portion of the received information to a computing device associated with a lender and confirming, to a computing device associated with a borrower or a merchant that the information has been sent to the lender.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Abstract: Described here is a method for reducing or preventing Pseudomonas aeruginosa biofilm formation in a human subject in need thereof, comprising administering to the human subject a first composition comprising (a) an antigen-binding polypeptide that binds Pf-family bacteriophage, or (b) a vaccine against Pf-family bacteriophage. Also described is an antigen-binding polypeptide that binds specifically to a CoaB protein of Pf-family bacteriophage or fragment thereof.

Abstract: Thermoelectric devices and methods for making and using the devices and their intermediates are provided. Membrane-supported thermoelectric modules are fabricated by dispensing thermoelectric powder into select locations of a membrane to form electrically isolated columns of thermoelectric material. The powder is then sintered or fused to form thermoelectric elements, which are then electrically connected and combined with thermal interface films to form the modules. The modules are the building blocks of electrical current generating, thermoelectric cooling and heat scavenging thermoelectric devices.

Abstract: Provided herein are bifunctional compounds that bind a target protein (e.g., a selected protein) and/or induce ubiquitination for degradation of the target protein. In particular, provided are compounds that bind a bromodomain or bromodomain-containing protein (e.g., BET proteins) or histone methyltransferases (HMTs, e.g., enhancer of zeste homolog 1 (EZH1), or FKBP12) and can promote its degradation by recruiting it to the ubiquitin receptor RPN13 (e.g., RA190), for proteasomal degradation. Also provided are pharmaceutical compositions comprising the bifunctional compounds, methods of treating and/or preventing diseases (e.g., proliferative diseases, cancers, benign neoplasms, pathological angiogenesis, inflammatory diseases, and autoimmune diseases) and musculoskeletal diseases, and methods of inducing the degradation of a target (e.g., a target protein) by recruiting it to the ubiquitin receptor RPN13 of the proteasome in a subject by administering a compound or composition described herein.

Abstract: There is described herein a method of predicting disease progression risk in a subject with prostate cancer, the method comprising: a) providing a sample containing RNA and DNA material from tumour cells; b) determining or measuring values for substantially all of patient features listed for PRONTO-e or PRONTO-m in Table 6, and some or all reference or control features set forth in Table 6; c) comparing said patient features to the reference or control features; and d) computing a prediction score using a classifier that takes said patient feature values as input, the classifier having been previously trained on samples from a population of early prostate cancer patients.

Abstract: The invention is a magnetic mounting apparatus for electronic devices used to film sports motion, personal content, and hands-free video and music streaming. The mounting apparatus includes a silicone coated threaded magnet, a clamp lined with a rubber mold, and an adjustable toggle latch locking clasp that allows attachment to rods or shafts of varying widths. The threaded magnet is of sufficient magnetic force to securely support the electronic device. Such electronic devices include and are not limited to smart phones, tablets, and cameras. A metal ferrous plate is attached to the electronic device with adhesive, thereby providing a secure magnetic connection between the mounting apparatus and electronic device.

Abstract: An image processing method including: capturing changes in a monitored scene; and performing a sparse feature calculation on the changes in the monitored scene to obtain a sparse feature map.

Abstract: This invention relates to a monopod device for use with a phone, tablet, camera, and other recording devices that is supported by the monopod and is inserted into the ground to provide hands-free photographing, video recording, and streaming of music and video. The monopod device includes a magnetic mounting system for electronic devices, silicone covered threaded magnet, ferrous metal plate with adhesive, rotational adjustment mechanism, and non-collapsible support hollow shaft. The hollow shaft with a pointed plug is constructed to be inserted into the ground to provide stable hands-free filming and use of the electronic device. The rotational adjustment mechanism having a swivel secures the threaded magnet allows different filming and viewing angles. The threaded magnet provides powerful pulling power that allows coupling of small electronic devices. This invention has a cradle free design providing safe and easy one-handed device use. The invention provides a solution to filming sports motion.

Abstract: The invention concerns methods for early detection, monitoring and prognosis of a flavivirus-induced infection, comprising the detection of a complex formed by the flavivirus non-structural glycoprotein NS1 and plasma lipoprotein particles in a biological anti-NS1 Mab sample during the clinical phase of the infection.

Abstract: A micro device transfer tool and methods of operation are described. In an embodiment, the micro device transfer tool includes an articulating transfer head assembly capable of six degrees of motion. A miniatured camera assembly may be secured near the point of contact for the articulating transfer head assembly to aid in system alignment. In an embodiment, an encoder system is described for alignment of a micro pick up array and target substrate using complementary concentric grating patterns. In an embodiment a miniaturized position sensor design is described for sensing position of various system components during alignment or pick and place processes.

Abstract: The invention is a magnetic mounting apparatus for electronic devices used to film sports motion, personal content, and hands-free video and music streaming. The mounting apparatus includes a silicone coated threaded magnet, a clamp lined with a rubber mold, and an adjustable toggle latch locking clasp that allows attachment to rods or shafts of varying widths. The threaded magnet is of sufficient magnetic force to securely support the electronic device. Such electronic devices include and are not limited to smart phones, tablets, and cameras. A metal ferrous plate is attached to the electronic device with adhesive, thereby providing a secure magnetic connection between the mounting apparatus and electronic device.

Abstract: The present disclosure is directed to systems and methods for restoring custodian-based data. The method includes, for example, (i) receiving a request for restoring custodian-based data associated with multiple custodians; (ii) identifying, in a query index, one or more custodian actions associated with the multiple custodians based on the request; and (iii) generating data associated with the identified one or more custodian actions in a format indicated by the request. The one or more custodian actions correspond to one or more immutable identifiers.

Abstract: The present disclosure is directed to systems and methods for searching custodian-based data. The method includes, for example, retrieving custodian-based data associated with multiple custodians; retrieving immutable identifiers associated with one or more custodian actions associated with multiple custodians; generating a query index the custodian-based data at least based on the one or more custodian actions; and searching the custodian-based data based on the query index and the immutable identifiers. The query index can include one or more data items, and each of the data items of the query index is associated with one of the immutable identifiers.