Patents by Inventor Paul Peluso

Paul Peluso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reactive surfaces, substrates and methods of producing and using same
    Publication number: 20090061429
    Abstract: Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 5, 2009
    Applicant: Pacific Biosciences of California, Inc
    Inventors: Daniel Roitman, Paul Peluso, Mathieu Foquet
  • Substrates for performing analytical reactions
    Patent number: 7486865
    Abstract: Substrates, including zero mode waveguide substrates that have been fabricated to provide additional functional elements and/or components including increased volumes for positioning of active surfaces and/or components for the mitigation of negative electrochemical properties of the underlying substrates.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: February 3, 2009
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Mathieu Foquet, Paul Peluso, Stephen Turner, Daniel Bernardo Roitman, Geoffrey Otto
  • Active surface coupled polymerases
    Publication number: 20080199932
    Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
    Type: Application
    Filed: October 26, 2007
    Publication date: August 21, 2008
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: David Hanzel, Jonas Korlach, Paul Peluso, Geoffrey Otto, Thang Pham, David Rank, Stephen Turner
  • Articles having localized molecules disposed thereon and methods of producing same
    Publication number: 20080176769
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Application
    Filed: October 26, 2007
    Publication date: July 24, 2008
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto
  • Polymerase enzymes and reagents for enhanced nucleic acid sequencing
    Publication number: 20080108082
    Abstract: Compositions that include DNA polymerases having increased residence times for nucleotide analogues, particularly modified recombinant ?29-type DNA polymerases with such increased residence times, are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA amplification are also provided. Compositions including ?-thiophosphate nucleotide analogues with four or more phosphate groups are described, as are methods for determining the sequence of nucleic acid molecules using such analogues.
    Type: Application
    Filed: October 22, 2007
    Publication date: May 8, 2008
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: David Rank, Arek Bibillo, David Hanzel, Paul Peluso, Jeff Wegener
  • SUBSTRATES FOR PERFORMING ANALYTICAL REACTIONS
    Publication number: 20080095488
    Abstract: Substrates, including zero mode waveguide substrates that have been fabricated to provide additional functional elements and/or components including increased volumes for positioning of active surfaces and/or components for the mitigation of negative electrochemical properties of the underlying substrates.
    Type: Application
    Filed: June 11, 2007
    Publication date: April 24, 2008
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Mathieu Foquet, Paul Peluso, Stephen Turner, Daniel Roitman, Geoffrey Otto
  • Articles having localized molecules disposed thereon and methods of producing same
    Publication number: 20080032301
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Application
    Filed: March 29, 2007
    Publication date: February 7, 2008
    Applicant: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
    Inventors: David Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto
  • CONTROLLED INITIATION OF PRIMER EXTENSION
    Publication number: 20080009007
    Abstract: Controlled initiation of primer extension in determination of nucleic acid sequence information by incorporation of nucleotides or nucleotide analogs. Preferred aspects include photo-initiated extension through the use of photo-cleavable blocking, groups on termini of primer sequences followed by non-terminating primer extension using nucleotides or nucleotide analogs that are not extension terminators.
    Type: Application
    Filed: June 15, 2007
    Publication date: January 10, 2008
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: John Lyle, Paul Peluso, Gene Shen
  • Immobilization of glycoproteins
    Publication number: 20070293659
    Abstract: Methods and compositions for the immobilization of glycoproteins are presented herein. In addition, the present invention provides arrays of immobilized glycoproteins. The methods of immobilizing glycoproteins include oxidation of the glycosyl moiety.
    Type: Application
    Filed: January 12, 2007
    Publication date: December 20, 2007
    Inventors: Paul Peluso, Carolyn Bertozzi
  • Polymerases for nucleotide analogue incorporation
    Publication number: 20070196846
    Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
    Type: Application
    Filed: December 21, 2006
    Publication date: August 23, 2007
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: David Hanzel, Geoff Otto, Devon Murphy, Paul Peluso, Thang Pham, David Rank, Paul Mitsis
  • Reactive surfaces, substrates and methods of producing same
    Publication number: 20070077564
    Abstract: Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses.
    Type: Application
    Filed: September 30, 2005
    Publication date: April 5, 2007
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Daniel Roitman, Paul Peluso, Mathieu Foquet
  • Immobilization of glycorproteins
    Publication number: 20060035389
    Abstract: Methods and compositions for the immobilization of glycoproteins are presented herein. In addition, the present invention provides arrays of immobilized glycoproteins. The methods of immobilizing glycoproteins include oxidation of the glycosyl moiety.
    Type: Application
    Filed: May 15, 2003
    Publication date: February 16, 2006
    Inventors: Paul Peluso, Carolyn Bertozzi