Patents by Inventor Paul Pevsner

Paul Pevsner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
    Patent number: 8525104
    Abstract: The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: September 3, 2013
    Assignee: New York University
    Inventors: Paul Pevsner, Frederick Naftolin, Douglas C. Miller, Dean Hillman, Brian K. Stall, Steven M. Wishnies
  • Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
    Publication number: 20110062320
    Abstract: The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.
    Type: Application
    Filed: April 27, 2010
    Publication date: March 17, 2011
    Inventors: Paul Pevsner, Frederick Naftolin, Douglas C. Miller, Dean Hillman, Brian K. Stall, Steven M. Wishnies
  • Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
    Patent number: 7714276
    Abstract: The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: May 11, 2010
    Assignee: New York University
    Inventors: Paul Pevsner, Frederick Naftolin, Douglas C. Miller, Dean Hillman, Brian K. Stall, Steven M. Wishnie
  • Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
    Publication number: 20070114375
    Abstract: The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.
    Type: Application
    Filed: September 29, 2006
    Publication date: May 24, 2007
    Inventors: Paul Pevsner, Frederick Naftolin, Douglas Miller, Dean Hillman, Brian Stall, Steven Wishnies
  • Methods for preparation of live body tissues for examination
    Publication number: 20070110666
    Abstract: A minimally invasive procedure for perfusion-impregnation of tissues, organs and cells is provided that aids in the retention of tissue and cellular architecture without the formation of artifacts. The procedure allows for monitoring drug disposition, for detecting diseased tissue and for monitoring the presence of target molecules in a sample using various imaging techniques, including matrix assisted laser desorption ionization mass spectrometry (MALDI-MS).
    Type: Application
    Filed: September 28, 2006
    Publication date: May 17, 2007
    Inventors: Paul Pevsner, Frederick Naftolin, Ahmed Metwaly, Erol Gulcicek