Abstract: Herein is reported a bispecific antibody specifically binding to human Abeta protein and human transferrin receptor (bispecific anti-Abeta/TfR antibody) as well as the use of such bispecific antibodies as a medicament in the treatment of Alzheimer's Disease, including where the bispecific antibody is administered intravenously at a dose of 0.2 mg/kg to 7.2 mg/kg once every four weeks.

Abstract: A protection system comprises at least one inflatable safety structure, each associated with a gas generator that can be activated by an external command, wherein the external command comprises an electrical signal from an automated system that is responsible for the critical safety functions of a vehicle, corresponding to predictive information about an impact. The gas generator is configured to generate a gas over a time period such that the total inflation time of the inflatable structure is greater than 50 milliseconds. The inflatable structure may be waterproof.

Abstract: Embodiments herein are directed to methods of heterotrophically culturing a. Embodiments herein are directed to methods, systems, and bioreactors for heterotrophically culturing Euglena sp. microorganism, a Schizochytrium sp. microorganism, or a Chlorella sp. microorganism comprising: culturing the microorganism in a culture media containing one or more carbon source, one or more nitrogen source, and one or more salt; maintaining a pH of between about 2.0 to about 4.0; maintaining a temperature of about 20° C. to about 30° C.; and maintaining an environment with substantially no light; wherein the culturing occurs in three cultivation stages.

Abstract: A mobile elevating work platform includes a chassis and fixed wheels, caster wheels, and a driving and steering wheel secured to the chassis. A control implement coupled with the driving and steering wheel is configured to adjust a steering position of the driving and steering wheel. A drive motor is operable to drive the driving and steering wheel. A platform may be raisable and lowerable with a mast assembly. The control implement may be adjustable to accommodate operator physical characteristics.

Abstract: A protection system comprises at least one inflatable safety structure, each associated with a gas generator that can be activated by an external command, wherein the external command comprises an electrical signal from an automated system that is responsible for the critical safety functions of a vehicle, corresponding to predictive information about an impact. The gas generator is configured to generate a gas over a time period such that the total inflation time of the inflatable structure is greater than 50 milliseconds. The inflatable structure may be waterproof.

Abstract: The present invention teaches apparatuses and methods for transcatheter removal of mechanical heart valve leaflets from a subject. The invention also teaches methods for subsequent transcatheter placement of a bioprosthesis within the annulus that remains after the leaflets are removed. Advantageously, the devices and methods of the present invention can be used without a heart-lung machine.

Abstract: A mobile elevating work platform includes a chassis and fixed wheels, caster wheels, and a driving and steering wheel secured to the chassis. A control implement coupled with the driving and steering wheel is configured to adjust a steering position of the driving and steering wheel. A drive motor is operable to drive the driving and steering wheel. A platform may be raisable and lowerable with a mast assembly. The control implement may be adjustable to accommodate operator physical characteristics.

Abstract: A blade dispenser is provided that includes a housing, a carrier, and a blade eject assembly. The housing defines a carrier cavity having an open end, and includes a blade loading mechanism. The carrier is operable to hold a plurality of blades. The carrier is selectively disposable within the carrier cavity of the housing. The blade eject assembly includes a button biased in a normal position relative to a base. The button is operable to be moved relative to the base and engage a blade disposed within the carrier, and to move the blade to a position where at least a part of the blade is disposed outside the housing.

Abstract: A blade dispenser is provided that includes a housing, a carrier, and a blade eject assembly. The housing defines a carrier cavity having an open end, and includes a blade loading mechanism. The carrier is operable to hold a plurality of blades. The carrier is selectively disposable within the carrier cavity of the housing. The blade eject assembly includes a button biased in a normal position relative to a base. The button is operable to be moved relative to the base and engage a blade disposed within the carrier, and to move the blade to a position where at least a part of the blade is disposed outside the housing.

Abstract: The present invention teaches apparatuses and methods for transcatheter removal of mechanical heart valve leaflets from a subject. The invention also teaches methods for subsequent transcatheter placement of a bioprosthesis within the annulus that remains after the leaflets are removed. Advantageously, the devices and methods of the present invention can be used without a heart-lung machine.

Abstract: A system for removably securing a component to a base. The system includes a plurality of attachment means, each having a first attachment mechanism fixedly secured to the base, and a second attachment mechanisms fixedly secured to the component. Each of the first attachment mechanisms is configured to correspond to, and engage with, one of the second attachment mechanisms to securely fasten the component to the base. The plurality of first attachment mechanisms and the plurality of second attachment mechanisms are configured such that a gap is formed between the component and the base, and a void is formed between the plurality of attachment means when the attachment mechanisms are engaged, to create a leverage point directly above the void that allows the attachment mechanisms to at least partially disengage and the component to be removed from the base when a force is applied to the leverage point.

Abstract: A system for removably securing a component to a base. The system includes a plurality of attachment means, each having a first attachment mechanism fixedly secured to the base, and a second attachment mechanisms fixedly secured to the component. Each of the first attachment mechanisms is configured to correspond to, and engage with, one of the second attachment mechanisms to securely fasten the component to the base. The plurality of first attachment mechanisms and the plurality of second attachment mechanisms are configured such that a gap is formed between the component and the base, and a void is formed between the plurality of attachment means when the attachment mechanisms are engaged, to create a leverage point directly above the void that allows the attachment mechanisms to at least partially disengage and the component to be removed from the base when a force is applied to the leverage point.

Abstract: A gas generator for a safety system includes an explosible charge formed at least by a primary pyrotechnic compound, in a first chamber initiated by at least one initiator provided with a reinforcing charge and a secondary compound, in a second chamber, the decomposition of which is entailed by products of combustion of the primary compound, an interaction of the products of combustion of the primary compound and those of the secondary compound through an oxidation-reduction reaction occurring in a slightly confined volume, the first chamber communicating with said second chamber through a central nozzle and said second chamber being provided, at a first zone close to said first chamber, with orifices that discharge the gases and contain, in a second zone, said secondary compound; and means forming an obstacle to the passage of the gases installed in said second chamber between said first and second zones, said obstacle-forming means allowing the gases to pass into a central part and forming an obstacle to th

Abstract: The invention relates to a hydrogen reservoir comprising a substance suitable for storing hydrogen wherein said substance is made up of nano-structured silicon. It also relates to a process for manufacturing and a method for use of this hydrogen reservoir.

Abstract: A device for deploying an element including a detonatable charge formed from at least one primary pyrotechnic compound; at least one initiator equipped with a reinforcing charge to initiate decomposition of the primary pyrotechnic compound(s); a secondary compound having a decomposition rate less than the decomposition rate of the primary pyrotechnic compound(s) such that the primary pyrotechnic compound(s) control(s) decomposition of the secondary compound(s) after initialization of decomposition; and at least one unconfined or weakly confined interaction chamber wherein the primary pyrotechnic compound(s) enable(s) at least one interaction of combustion products of the reducing primary compound(s) and oxidizing secondary compound(s) by oxidoreduction reaction.

Abstract: A device for protecting goods and/or persons including a security element; and a gas generating system connected to the security element and including an explosive charge formed at least of: a primary pyrotechnic compound, in a first chamber, initiated by at least one initiator having a reinforcing charge and including at least one propellant having an optionally adjusted oxygen balance, and a secondary compound, in a secondary chamber, including an oxidant constituent capable of delivering only gas by decomposition and at least one reducing additive having a function of contributing nitrogen, the additive being present in a proportion by weight less than about 70% of the weight of the primary-secondary compound.

Abstract: A gas generator for a safety system includes an explosible charge formed at least by a primary pyrotechnic compound, in a first chamber initiated by at least one initiator provided with a reinforcing charge and a secondary compound, in a second chamber, the decomposition of which is entailed by products of combustion of the primary compound, an interaction of the products of combustion of the primary compound and those of the secondary compound through an oxidation-reduction reaction occurring in a slightly confined volume, the first chamber communicating with said second chamber through a central nozzle and said second chamber being provided, at a first zone close to said first chamber, with orifices that discharge the gases and contain, in a second zone, said secondary compound; and means forming an obstacle to the passage of the gases installed in said second chamber between said first and second zones, said obstacle-forming means allowing the gases to pass into a central part and forming an obstacle to th

Abstract: A bit for drilling a hole.

Abstract: The invention relates to a process for dissolving a gas with short-lived physical properties in a liquid, comprising the steps of providing the gas with short-lived physical properties, providing the liquid and bringing the gas with short-lived with short-lived physical properties is fed into the liquid via a semi-permeable membrane that is permeable to gas.