Patents by Inventor Paul Plotz

Paul Plotz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DISABLING AUTOPHAGY AS A TREATMENT FOR LYSOSOMAL STORAGE DISEASES
    Publication number: 20130331309
    Abstract: Provided herein are methods of treating lysosomal storage disease, for instance Pompe disease, through inhibition of autophagy. Optionally, treatment is administered as an adjunct to enzyme replacement therapy (ERT).
    Type: Application
    Filed: August 19, 2013
    Publication date: December 12, 2013
    Inventors: Nina Raben, Tao Xie, Cynthia Schreiner, Rebecca Baum, Shoichi Takikita, Paul Plotz
  • Synthesis and secretion of native recombinant lysosomal enzymes by liver
    Publication number: 20040203096
    Abstract: The invention provides recombinant native lysosomal enzymes produced by liver cells, preferably in vitro, and methods of using the native recombinant lysosomal enzymes to treat enzyme deficiencies in vivo. Lysosomal enzymes, including acid alpha-glucosidase (GAA), produced by liver cells apparently undergo the post-translational modifications necessary to achieve good enzymatic activity. The resulting enzymes can be taken up by various other cells and can correct phenotypic abnormalities of distant organs with enzyme deficiencies. In certain preferred embodiments, the enzyme is GAA and the methods are especially adapted for treatment of type II glycogen storage disease in mammals, including humans.
    Type: Application
    Filed: May 14, 2004
    Publication date: October 14, 2004
    Inventors: Nina Raben, Nina Lu, Bo Yan, Paul Plotz, Yesenia Rivera
  • Assay using recombinant histidyl-tRNA synthetase
    Patent number: 5663066
    Abstract: Recombinant Histidyl tRNA synthetase produced by non-mammalian host cells is used in a sensitive assay to determine the presence of autoimmune diseases in mammals. Methods for isolating, cloning and expressing rHRS are described. In addition, a kit for determining the presence of an autoimmune disease is provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 2, 1997
    Assignees: The United States of America as represented by the Department of Health and Human Services, National Institutes of Health
    Inventors: Nina Raben, Ralph Nichols, Paul Plotz, Richard Leff
  • Assay using recombinant histidyl-tRNA synthetase
    Patent number: 5484703
    Abstract: Recombinant Histidyl tRNA synthetase produced by non-mammalian host cells is used in a sensitive assay to determine the presence of autoimmune diseases in mammals. Methods for isolating, cloning and expressing rHRS are described. In addition, a kit for determining the presence of an autoimmune disease is provided.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: January 16, 1996
    Assignee: United States of America
    Inventors: Nina Raben, Ralph Nichols, Paul Plotz, Richard Leff