Abstract: In response to receiving a request from a querying entity, such as a seller of goods or services, embodiments of a service engine present to a client computing device of the querying entity a set of queries about goods or services sold by the querying entity and other characteristics of the business of the querying entity. The service engine may intelligently determine which queries to present based on responses to preceding queries. The service engine may then compare the entries in response to the queries against stored rules for a one or more of a plurality of tax jurisdictions, the stored rules being about establishing nexus for purposes of remitting transaction tax in the certain tax jurisdiction. The service engine may then determine information regarding potential lack of tax compliance of the querying entity based on the comparison, and notify accordingly.

Abstract: An imaging system includes a first portion and a second portion that translates and/or rotates with respect to the first portion. A first locking mechanism may prevent the second portion from translating with respect to the first portion, such as during transport of the system. A second locking mechanism may prevent the second portion from rotating with respect to the first portion, such as during transport and/or during an imaging scan. Further embodiments include a cable management system between the first and second portions, a spherically-shaped surface of a support gimbal and a user interface device for an imaging system.

Abstract: A quetiapine fumarate composition for oral administration is provided comprising a pharmaceutically acceptable salt or solvate of quetiapine existing as a suspension in an aqueous carrier agent. The inventive liquid formulation demonstrates high bioavailability consistent with approved dosage forms, low agglomeration, reduced content of excipients commonly used in solid oral dosage forms and extended shelf life stability. Also provided is a method of manufacturing a liquid quetiapine suspension composition for oral administration and methods of administering therapeutically effective dosages of an oral liquid quetiapine suspension composition to patients in need thereof.

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R3 have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.

Abstract: The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.

Abstract: Updating data in a distributed system, in which a data coordinator receives a proposed change to a data element, locks the data element, and sends an invalidation command to nodes in the distributed system. If all nodes acknowledge the invalidation command, the data coordinator updates the data element locally and unlocks the data element. If not all nodes acknowledge the invalidation command, the data coordinator terminates the proposed change and unlocks the data element. Each node that invalidated the data element requests the data element. The data coordinator returns its current value. If the value is changed, all nodes request and receive the update. If a node did not invalidate, it will not request an update, but the value will not have changed so all requesting nodes receive the previous value. Thus, all nodes have the same value for the data element and consistency is maintained throughout the system.

Abstract: An operating system on a computer system can comprise a user space, which can comprise a persistent data store, and a kernel space, which can be extended by loading kernel modules. As provided herein, the kernel space can utilize kernel designated electronically addressed non-volatile memory (e.g., flash memory) to cache data from the user space persistent store, for example, upon a boot event. The kernel space can further comprise a cache controller that can be used to populate the kernel electronically addressed non-volatile memory with kernel in-memory data caches that comprise user space persistently stored data. In one embodiment, the kernel space can further comprise kernel designated volatile main memory (e.g., RAM), which can be used in conjunction with the kernel electronically addressed non-volatile memory to cache user space persistently stored data. In this way, kernel modules may access user space persistent store data from the RAM and/or electronically addressed non-volatile kernel cache.

Abstract: An operating system on a computer system can comprise a user space, which can comprise a persistent data store, and a kernel space, which can be extended by loading kernel modules. As provided herein, the kernel space can utilize kernel designated electronically addressed non-volatile memory (e.g., flash memory) to cache data from the user space persistent store, for example, upon a boot event. The kernel space can further comprise a cache controller that can be used to populate the kernel electronically addressed non-volatile memory with kernel in-memory data caches that comprise user space persistently stored data. In one embodiment, the kernel space can further comprise kernel designated volatile main memory (e.g., RAM), which can be used in conjunction with the kernel electronically addressed non-volatile memory to cache user space persistently stored data. In this way, kernel modules may access user space persistent store data from the RAM and/or electronically addressed non-volatile kernel cache.

Abstract: Apparatus and method for a T-shaped wrench having three drive stems including a base drive stem wherein the top portion of the wrench has opposing ends or drive stems which are 30 degrees offset from each other. The angularly offset drive stems of the top portion allow the wrench to be used in tight areas where other wrenches are not usable.

Abstract: A container for holding a sample is presented. The container has a substantially cylindrical vial defining an interior cavity and a longitudinal axis. The vial has a first end, an opposed second end, and a circumferential sidewall. The first end of the vial is open for access to the interior cavity and the second end is closed. In one aspect, the circumferential sidewall has a first sidewall portion located proximate the first end projecting inwardly into the interior cavity, and a second sidewall portion positioned between the first sidewall portion and the second end projecting inwardly into the interior cavity.

Abstract: A vial package includes a tray having one or more spaced apart openings disposed therein with dimensions corresponding to a lower portion of a vial, and a lid having one or more spaced apart openings disposed therein with dimensions corresponding to an upper portion of the vial. The one or more bottom tray openings and the one or more lid openings are arranged such that the vial when disposed within the package is securely held in place.

Abstract: A process is provided for inspecting an absorbent article constructed from multiple components. A filtered image is produced from the absorbent article. In the image of the absorbent article, a nonlinear first edge and a second edge are identified at a location where there is a course change in contrast. A center point and centerline of the absorbent article is calculated using the position of the first edge and the second edge. A skew of the absorbent article is calculated. These known locations are utilized to define at least one additional region of the image for further analysis. A third edge and fourth edge are identified at a location where there is a fine change in contrast. The skew of the third edge and the fourth edge within the defined region is calculated and compared to known parameters for the absorbent article.

Abstract: A method of forming a suspended semiconductor film is provided comprising providing a semiconductor structure including a layer of semiconductor film over a sacrificial layer, the semiconductor film secured to a substrate; depositing a film of material over the semiconductor film that has a tensile or compressive strain with respect to the semiconductor film patterning the deposited film to leave opposed segments spaced from each other by a central portion of the semiconductor film; patterning the semiconductor film and removing the sacrificial layer beneath the semiconductor film to leave a semiconductor film section anchored to the substrate at at least two anchor positions, with the film segments remaining on the semiconductor film adjacent to the anchor positions and spaced from each other by the central position of the suspended semiconductor film such that the film segments apply a tensile or compressive stress to the suspended semiconductor film.