Abstract: A pharmaceutical composition for anti-viral treatment for papillomavirus associated diseases in mammals, comprising a therapeutically effective amount of Ovatodiolide or Ovatodiolide related substances or an enriched plant extract containing anisomelic acid and ovatiodiolide. The pharmaceutical composition may comprise Ovatodiolide or Ovatodiolide related substances or the enriched extract in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a co-solvent or surfactant or a combination thereof. A method of treating or preventing papillomavirus associated diseases in a mammal is also provided.