Patents by Inventor Paul R. August

Paul R. August has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BCAT MODULATION
    Publication number: 20220274967
    Abstract: This disclosure relates to, in part, the treatment of an organic acidemia in a subject in need thereof via administration of a therapeutically effective amount of compounds that inhibit BCAT2. The disclosure also relates to, in part, methods for identifying a candidate compound for treatment of organic acidemias.
    Type: Application
    Filed: July 8, 2020
    Publication date: September 1, 2022
    Inventors: Paul R. August, Margaret Kenney, Jacques Mauger, Mark Drew, Weixi Kong
  • Transposon mediated multiplex sequencing
    Patent number: 7229798
    Abstract: The present invention relates to an automated method of transposon-mediated multiplex sequencing of DNA fragments inserted into a vector. It relates more particularity to an increased efficiency in such automated methods, where the increased efficiency is obtained by screening out before the sequencing those constructs in which the transposon inserted into the vector sequence. This prevents a waste of time and resources in performing reactions sequencing the vector instead of the DNA fragments of interest.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: June 12, 2007
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Paul R. August, Pamela J. Keagle, Henry Long, Anna Wiencis Montmayeur, Katherine Call, Michael Draper
  • Vectors for improving cloning and expression in low copy number plasmids
    Patent number: 6818441
    Abstract: Improved vectors and related materials and methods are disclosed.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: November 16, 2004
    Assignees: Aventis Pharmaceuticals Inc., Ariad Pharmaceuticals Inc.
    Inventors: Trudy Grossman, Ian MacNeil, Paul R. August
  • Transposon mediated multiplex sequencing
    Publication number: 20030219779
    Abstract: The present invention relates to an automated method of transposon-mediated multiplex sequencing of DNA fragments inserted into a vector. It relates more particularity to an increased efficiency in such automated methods, where the increased efficiency is obtained by screening out before the sequencing those constructs in which the transposon inserted into the vector sequence. This prevents a waste of time and resources in performing reactions sequencing the vector instead of the DNA fragments of interest.
    Type: Application
    Filed: May 5, 2003
    Publication date: November 27, 2003
    Inventors: Paul R. August, Pamela J. Keagle, Henry Long, Anna Wiencis Montmayeur, Katherine Call, Michael Draper
  • Genes encoding resistance to DNA alkylating agents
    Patent number: 6524812
    Abstract: The invention provides genes encoding resistance to DNA bioreductive alkylating or cleaving agents and methods of identifying and using those genes.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: February 25, 2003
    Assignee: Regents of the University of Minnesota
    Inventors: David H. Sherman, Paul R. August, Michael C. Flickinger
  • Direct calcium magnesium acetate production
    Patent number: 5316928
    Abstract: The invention provides a method for the direct biological production of calcium magnesium acetate using a novel combination of an aerobic thermophilic bacterium of the genus Bacillus, capable of supporting the sustained production of substantial quantities of acetic acid at low pH, high temperatures, and high salt concentrations. Strains of bacterium of the genus Bacillus selected and isolated for use in the present invention produce acetic acid in the presence of a neutralizing source of calcium and magnesium ions, such as dolomitic lime, to produce substantial quantities of calcium magnesium acetate.
    Type: Grant
    Filed: June 24, 1992
    Date of Patent: May 31, 1994
    Assignee: Regents of the University of Minnesota
    Inventors: Michael C. Flickinger, Richard S. Hanson, Frederick J. Schendel, Charles R. Anderson, Paul R. August
  • Anomer enrichment of alkyl glycosides of amino sugars
    Patent number: 4250301
    Abstract: Process for enrichment of .beta.-anomers of alkyl glycosides of amino sugars involving two steps. The first step comprises treating an equilibrium mixture of the .alpha.- and .beta.-anomers of the alkyl glycosides with an inorganic base under controlled reaction conditions, e.g., specific solvents, water content of solvent and temperature and time of treatment. These conditions cause the equilibrium to shift in favor of the .beta.-anomer. The second step comprises subjecting the product of the first step to multiple fractionations in specific solvent mixtures to isolate products having increased proportions of the .beta.-anomers of the alkyl glycosides of amino sugars.
    Type: Grant
    Filed: September 24, 1979
    Date of Patent: February 10, 1981
    Assignee: University of Delaware
    Inventors: Paul R. August, George A. Reed