Abstract: The present invention relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.

Abstract: A signature set of genes associated with hepatitis C virus infection is described.

Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.

Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site-binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.

Abstract: A system for delivering fluids which includes a pump (such as a peristaltic pump for example), a pump cartridge, a fluid reservoir, and a variety of fluid dispensers, including oral fluid dispensers. By providing a number of oral fluid dispensers, the one best suited for the needs of a particular application can be selected. The pump cartridge and/or the fluid dispensers may be disposable. The operation of the pump may be controlled based, at least in part, on the type of fluid dispenser being used. Further, a selectable mode can be used to further control the operation of the pump. The amount of fluids delivered over given periods of time may be monitored such that a reminder (such as an audio and/or visual alarm for example) may be provided if too much or too little fluid is delivered (and presumably consumed). The thresholds for such alarm conditions may be set and modified by a user. Further, the state of the fluid delivery system itself, as well as trends in fluid delivery, may be monitored.

Abstract: A system for delivering fluids which includes a pump (such as a peristaltic pump for example), a pump cartridge, a fluid reservoir, and a variety of fluid dispensers, including oral fluid dispensers. By providing a number of oral fluid dispensers, the one best suited for the needs of a particular application can be selected. The pump cartridge and/or the fluid dispensers may be disposable. The operation of the pump may be controlled based, at least in part, on the type of fluid dispenser being used. Further, a selectable mode can be used to further control the operation of the pump. The amount of fluids delivered over given periods of time may be monitored such that a reminder (such as an audio and/or visual alarm for example) may be provided if too much or too little fluid is delivered (and presumably consumed). The thresholds for such alarm conditions may be set and modified by a user. Further, the state of the fluid delivery system itself, as well as trends in fluid delivery, may be monitored.

Abstract: A system for delivering fluids which includes a pump (such as a peristaltic pump for example), a pump cartridge, a fluid reservoir, and a variety of fluid dispensers, including oral fluid dispensers. By providing a number of oral fluid dispensers, the one best suited for the needs of a particular application can be selected. The pump cartridge and/or the fluid dispensers may be disposable. The operation of the pump may be controlled based, at least in part, on the type of fluid dispenser being used. Further, a selectable mode can be used to further control the operation of the pump. The amount of fluids delivered over given periods of time may be monitored such that a reminder (such as an audio and/or visual alarm for example) may be provided if too much or too little fluid is delivered (and presumably consumed). The thresholds for such alarm conditions may be set and modified by a user. Further, the state of the fluid delivery system itself, as well as trends in fluid delivery, may be monitored.

Abstract: The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an oligonucleotide, to crystallizable compositions of HCV helicase and an oligonucleotide and to methods of crystallizing an HCV helicase-oligonucleotide complex. The invention further relates to a computer programmed with the structure coordinates of the HCV helicase oligonucleotide binding pocket or the HCV helicase nucleotide triphosphate pocket wherein said computer is capable of displaying a three-dimensional representation of that binding pocket.

Abstract: An apparatus for printing and laminating plastic cards consists of a thermal transfer printing station including ribbon and a thermal printhead for printing an image on a receptor surface of a receptor card, a laminating station including laminating film and a heated laminating roller mounted for engagement with said receptor surface of said receptor card during a laminating operation, and a guided carriage for transporting the receptor card beneath the printhead and the heated laminating roller. The carriage includes a resilient surface for receiving the receptor card with a receptor surface facing upwardly. The carriage is guided on a pair of rails to insure proper registration and tracking of the receptor card. The carriage is driven by a threaded rod which passes through a threaded bore in the carriage wherein rotation of the threaded rod by a motor causes movement of the carriage along the guide rails.

Abstract: An apparatus for printing and laminating plastic cards consists of a thermal transfer printing station including ribbon and a thermal printhead for printing an image on a receptor surface of a receptor card, a laminating station including laminating film and a heated laminating roller mounted for engagement with said receptor surface of said receptor card during a laminating operation, and a guided carriage for transporting the receptor card beneath the printhead and the heated laminating roller. The carriage includes a resilient surface for receiving the receptor card with a receptor surface facing upwardly. The carriage is guided on a pair of rails to insure proper registration and tracking of the receptor card. The carriage is driven by a threaded rod which passes through a threaded bore in the carriage wherein rotation of the threaded rod by a motor causes movement of the carriage along the guide rails.

Abstract: An apparatus for printing plastic cards consists of a thermal transfer printing station including ribbon and a thermal printhead for printing an image on a receptor surface of a receptor card, and a guided carriage for transporting the receptor card beneath the thermal printhead. The carriage includes a resilient surface for receiving the receptor card with a receptor surface facing upwardly. The carriage is guided on a pair of rails, and is driven by a threaded rod which passes through a threaded bore in the carriage, wherein rotation of the threaded rod by a motor causes movement of the carriage along the guide rails. The apparatus further includes a hopper for storing a plurality of cards for printing, and a cleaning station for cleaning the receptor surface of the card prior to printing. The threaded-rod driven carriage insures proper registration and tracking of the receptor card as it passes underneath the printhead.

Abstract: A magnetically encoded plastic card production system is provided which includes a supply mechanism for supplying a series of blank plastic cards. An encoder is operatively coupled to the supply mechanism which encodes a magnetic strip on each card. A separating mechanism is operatively coupled following the encoder which has a roller surface for adhesively attracting loose particles from a surface of each card. A design placing mechanism is operatively coupled immediately following the separating mechanism which places a graphic design on each card. In this arrangement, the loose particles are separated from each card subsequent to encoding the magnetic strip on each card and prior to placing the graphic design on each card. A collecting mechanism is operatively coupled to the design placing mechanism which collects each card after each card has passed through the encoder, separating mechanism, and design placing mechanism. A method for producing magnetically encoded plastic cards is also provided.

Abstract: An ambulatory patient monitoring system (100) is provided for measuring and storing predetermined diagnostic parameters of a patient. The monitoring system includes a personal type computer (120) which may be selectively coupled to the portable portion (102) of system (100). Portable portion (102) may include one or more monitoring modules, such as ECG monitoring unit (110) and blood pressure monitoring unit (210). When ECG monitoring unit (110) and blood pressure monitoring unit (210) are disposed in side-by-side relationship and with respective optical interfaces (50, 254) in optical alignment, the two units operate in concert. ECG monitoring unit (110) supplies an R-wave gating signal to blood pressure monitoring unit (210) for establishing a window in which the receipt of a Korotkoff sound is expected. Additionally, the ECG unit (110) may trigger the blood pressure unit (210) to take a reading responsive to unit (110) identifying a predetermined abnormality in the ECG signal.

Abstract: A slidable transport assembly is provided for a single-pass multi-color thermal printer including a plurality of platen rollers mounted in spaced relation, a web of receptor media received around the platen rollers, a plurality of print heads each mounted in corresponding relation to a respective platen roller, and a pair of drive rollers. The slidable transport assembly consists of a frame having a pair of spaced walls, a base for supporting the frame, a tray mounted on the base for holding the receptor media, and a slide rail for slidably supporting the base. The platen rollers and the drive rollers are mounted between the wall of the frame for integral movement thereof. The transport system is slidably movable between a printing position wherein the platen rollers are positioned beneath the print heads for printing, and a withdrawn position wherein the platen rollers are slidably withdrawn from beneath the print heads for receptor media loading.

Abstract: A removable cassette assembly is provided for mounting thermal transfer ribbon in a single-pass multi-color thermal printer. The thermal printer includes a platen roller, a web of receptor media received around the platen roller, a thermal print head, a cantilever support for mounting the print head in corresponding relation to the platen roller, and a pair of drive rollers for advancing the receptor media. The cassette assembly consists of a cassette body, a supply roll for storing a length of unused thermal transfer ribbon, a take-up roll for taking up used ribbon. The rolls are mounted for rotation on the cassette body and the cassette body is received onto the cantilever support for positioning of the ribbon between the print head and the receptor media. The ribbon is driven through the print nip by friction between the receptor media and the print head. The take-up roll engages with a drive motor when the cassette is received onto the cantilever for driving take-up of the ribbon.

Abstract: A pivotable mounting assembly for a thermal print head enables the print head to spherically pivot with respect to its associated support arm. The print head is attached to a mounting head and an associated support arm is attached to a cantilever support. A spherical bearing assembly interconnects the mounting head with the support arm and enables the print head to spherically pivot with respect to the support arm. The spherical bearing connection equalizes tangential pressure when the print head is biased against a platen roller. The mounting assembly further includes sub-assemblies for adjusting the rotational and front-to-back alignment of the print head dot line with respect to the support arm, as well as the side-to-side registration of the dot line.

Abstract: A seven color, single-pass thermal print engine includes three platen rollers equally spaced over a 180 degree arc, an uninterrupted length of receptor media which is received around the platens, three thermal printheads which make tangential contact with a respective platen, and a pair of output drive rollers for pulling the media around the platen rollers. The print engine further includes a media tensioning system consisting of a media tray, an "S" shaped media guide with an idler roll mounted inside the curve of the "S", a tensioning arm for applying tangential pressure to the receptor media and a pair of input pinch rollers. Color transfer ribbons surround each printhead and are contained in re-loadable cassettes. The platens, pinch rollers and tensioning assembly are mounted on a slide assembly so that the platen rollers, the pinch rollers and the tensioning system can be slidably withdrawn from the print engine for receptor media loading and ribbon cassette replacement.

Abstract: A Holter-type recorder unit for use with an ambulatory ECG recording system is described. The invention features real-time beat differentiation, including ST analysis and paced beat analysis of two or three channel sampled electrocardiogram data. The invention also features real-time coding of beat morphology and summary information on cassette tape. Further, summary information for an entire analysis can be compiled and reverse recorded onto the cassette tape at the end of the analysis to allow downloading thereof into an ECG scanner while the cassette is being rewound.

Abstract: An apparatus and method are described for removing particulate matter from one or more surfaces of a workpiece, such as a credit card blank, prior to printing a graphic design thereon. The apparatus includes a pair of cleaning rollers which engage both sides of the card, the cleaning rollers having an adhesive coating for removing loose particulate matter from the surfaces of the card. The apparatus also includes a stripper system for stripping collected particulate matter away from the cleaning rollers after a predetermined number of cards have been cleaned.

Abstract: A Holter-type recorder unit for use with an ambulatory ECG recording system is described. The recorder features real-time beat differentiation, including ST analysis and paced beat analysis of two or three channel sampled electrocardiogram data. The recorder also features real-time coding of beat morphology and summary information on cassette tape. Further, summary information for an entire analysis can be compiled and reverse recorded onto the cassette tape at the end of the analysis to allow downloading thereof into an ECG scanner while the cassette is being rewound.