Patents by Inventor Paul R. FLEMING

Paul R. FLEMING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230303526
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 28, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230219945
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 13, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING, Xiao ZHU
  • SMARCA DEGRADERS AND USES THEREOF
    Publication number: 20230173078
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 28, 2022
    Publication date: June 8, 2023
    Inventors: Yi ZHANG, Paul R. FLEMING, Xiao ZHU, Matthew M. WEISS
  • SMARCA DEGRADERS AND USES THEREOF
    Publication number: 20230149549
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiqitination and/or degradation by compounds. The compounds are bifunctional molecules that link a cereblon-binding moiety to a ligand that binds SMARCA and/or PB1 proteins.
    Type: Application
    Filed: June 10, 2020
    Publication date: May 18, 2023
    Inventors: Nan JI, Yi ZHANG, Michael D. SINTCHAK, Paul R. FLEMING
  • SMARCA INHIBITORS AND USES THEREOF
    Publication number: 20230103415
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 6, 2023
    Inventors: Yi ZHANG, Paul R. FLEMING, Xiao ZHU
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230089916
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
    Type: Application
    Filed: June 29, 2020
    Publication date: March 23, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230069104
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
    Type: Application
    Filed: June 29, 2020
    Publication date: March 2, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING
  • SMARCA DEGRADERS AND USES THEREOF
    Publication number: 20220331317
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 23, 2020
    Publication date: October 20, 2022
    Inventors: Yi ZHANG, Paul R. FLEMING, Xiao ZHU