Patents by Inventor Paul R. Gillis

Paul R. Gillis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for inhibiting angiogenesis
    Patent number: 7723313
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: May 25, 2010
    Assignee: Northwestern University
    Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
  • Methods and compositions for inhibiting angiogenesis
    Patent number: 7105496
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: September 12, 2006
    Assignee: Northwestern University
    Inventors: Noël P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
  • Methods and compositions for inhibiting angiogenesis
    Patent number: 6919309
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: July 19, 2005
    Assignee: Northwestern University
    Inventors: Noël P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
  • Methods and compositions for inhibiting angiogenesis
    Patent number: 6797691
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: September 28, 2004
    Assignee: Northwestern University
    Inventors: Noël P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
  • Methods and compositions for inhibiting angiogenesis
    Publication number: 20040014664
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
    Type: Application
    Filed: June 25, 2003
    Publication date: January 22, 2004
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
  • Methods and compositions for inhibiting angiogenesis
    Patent number: 6670333
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: December 30, 2003
    Assignee: Northwestern University
    Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis
  • Methods and compositions for inhibiting angiogenesis
    Publication number: 20030216286
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
    Type: Application
    Filed: January 14, 2003
    Publication date: November 20, 2003
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
  • Methods and compositions for inhibiting angiogenesis
    Patent number: 6391850
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: May 21, 2002
    Assignee: Northwestern University
    Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis
  • Methods and compositions for inhibiting angiogenesis
    Publication number: 20020002131
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.
    Type: Application
    Filed: June 6, 2001
    Publication date: January 3, 2002
    Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis
  • Methods and compositions for inhibiting angiogenesis
    Publication number: 20010049355
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.
    Type: Application
    Filed: June 6, 2001
    Publication date: December 6, 2001
    Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis
  • Methods and compositions for inhibiting angiogenesis
    Patent number: 6288024
    Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: September 11, 2001
    Assignee: Northwestern University
    Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis