Abstract: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: A planar hybrid optical amplifier is fabricated on a single crystal substrate. The components that are common to a variety of optical amplifier circuits are mounted on the substrate and the planar device that results is readily interchanged in various applications. In one embodiment the multiplexed signal consisting of light from a pump laser and an optical signal are introduced into a rare earth doped fiber which amplifies the input signal through stimulated emission of radiation.

Abstract: A coupler (2,3) comprises, a central single mode optical fiber (5) and N number of glass fibers (4), having radii of equal dimensions, fused together along biconic tapered sections (13, 13) to couple optical power from the central fiber (5) completely and uniformly to only the fibers (4) that have optical cores (6).

Abstract: An optical simulator 10, shaped to be interchangeable with a complimentary connector 7 that intermates with an optical connector housing 6 having an optical emitter 4 and an optical detector 5, comprises an alignment fixture with connectors for intermating with the optical emitter 4 and the optical detector 5. Included is an optical fiber 11 formed in a loop and installed within the alignment fixture 12 with a first end face 15 of the loop 11 aligned with the emitter 4 and a second end face 16 of the loop 11 aligned with the detector 5 of the optical connector 6. The simulator 10 is a solid molded body of an electrically insulating material. The optical fiber formed in a loop 11 further comprises an optical fiber having a rigid thin coating of electroplated metal 14.

Abstract: An optical matrix switch has N input ports and M output ports and M.times.(M-1) number of 1.times.2 fiber optics switch elements and M.times.(N-1) number of 2.times.1 fiber optic switch elements.

Abstract: An optical simulator 10, shaped to be interchangeable with a complimentary connector 7 that intermates with an optical connector housing 6 having an optical emitter 4 and an optical detector 5, comprises an alignment fixture with connectors for intermating with the optical emitter 4 and the optical detector 5. Included is an optical fiber 11 formed in a loop and installed within the alignment fixture 12 with a first end face 15 of the loop 11 aligned with the emitter 4 and a second end face 16 of the loop 11 aligned with the detector 5 of the optical connector 6. The simulator 10 is a solid molded body of an electrically insulating material. The optical fiber formed in a loop 11 further comprises an optical fiber having a rigid thin coating of electroplated metal 14.

Abstract: An optical fiber switch 9 comprises a group of optical fiber end faces 1, 2, 3, 4, 5, 6, including a first optical fiber end face 1 via which light is transmitted as an input signal and at least second and third optical end faces 2, 3 being the end faces of an optical loop 13. The group further includes a fourth fiber end face 4 via which light is transmitted as an output signal, and fifth and sixth fiber end faces 5, 6 being the end faces of an optical fiber loop 14. In a first position, light from the first fiber end face 1 is imaged into the second fiber end face 2 and is propagated through the fiber loop 13 to the third fiber end face 3 and imaged into the fourth fiber end face 4. In the second position, light from the first fiber end face 1 is imaged into the fifth fiber end face 5 and propagated through the fiber loop 14 through the sixth fiber end face 6 and imaged into the second fiber end face 2.

Abstract: A substantially reflection-less terminator 200,400 for an optical waveguide 102, 106 is disclosed. The termination is especially useful in preventing undesired reflections at the ends of unused fibers in an optical coupling device 100. In an illustrative embodiment, the terminator comprises a length of optical fiber 206. The front end of the fiber 206 is attached to a ferrule 222 for mating with a connector plug 10' attached to the end of the fiber to be terminated. The rear end of the fiber 206 is crushed at an angle and inserted into an index matching opaque adhesive material 230.

Abstract: The present invention provides an optical fiber connector comprising a connector receptacle, a mechanism associated with the connector receptacle for optically coupling two optical fibers together, and a compliant index matching film material positioned within the connector receptacle. When the optical fibers are inserted into the connector receptacle for optical coupling, the end faces of each of the optical fibers are in physical contact with the film material. Preferably, the connector is of the ferrule type, i.e., the optical fibers are located inside ferrules which are received and aligned within the connector receptacle so that the optical fibers are optically coupled together. A bayonet or threaded locking mechanism is associated with the connector receptacle and the ferrules for locking them into place within the connector receptacle.

Abstract: An optical simulator 10, shaped to be interchangeable with a complementary connector 7 that intermates with an optical connector housing 6 having an optical emitter 4 and an optical detector 5, comprises an alignment fixture 12 with connectors 21 and 22 for intermating with the optical emitter 4 and the optical detector 5, and an optical fiber 11 formed in a loop and installed within the alignment fixture 12 with a first end face 39 of the loop 11 aligned through a corresponding alignment fixture connector 24, with the emitter 4 and a second end face 37 of the loop 11 aligned through a corresponding alignment fixture 25, with the detector 5 of the optical connector 6. The optical fiber 11 further comprises an adjustable plunger mechanism 15 fitted through the body of the alignment fixture 12 to impose against the optical fiber 11 formed in a loop to thereby permit varying the degree of curvature of the loop by interjecting and retracting the plunger 15 against the loop.