Patents by Inventor Paul R. Rosteck, Jr.

Paul R. Rosteck, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Platenolide synthase gene
    Patent number: 5945320
    Abstract: A DNA molecule isolated from Streptomyces ambofaciens encodes the multi-functional proteins which direct the synthesis of the polyketide platenolide.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Stanley G. Burgett, Stuart A. Kuhstoss, Ramachandra N. Rao, Mark A. Richardson, Paul R. Rosteck, Jr.
  • Polyketide synthase genes
    Patent number: 5876991
    Abstract: A DNA molecule isolated from Streptomyces fradiae encodes the multi-functional proteins which direct the synthesis of the polyketide tylactone.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: March 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Bradley S. DeHoff, Stuart A. Kuhstoss, Paul R. Rosteck, Jr., Kimberly L. Sutton
  • DNA encoding a novel penicillin binding protein from streptococcus pneumoniae
    Patent number: 5789202
    Abstract: The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.
    Type: Grant
    Filed: October 17, 1996
    Date of Patent: August 4, 1998
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, S. Richard Jaskunas, Jr., Pamela K. Rockey, Paul R. Rosteck, Jr., Franklin H. Norris
  • Bacteriophage Lambda pL promoters
    Patent number: 5576190
    Abstract: The present invention concerns novel DNA compounds which function as transcriptional activating sequences. Recombinant DNA expression vectors which contain the transcriptional activating sequences and host cells transformed with these expression vectors are also provided. When properly positioned in an expression vector, the novel transcriptional activating sequences enable regulatable expression of an operably linked gene and enhance the structural stability of the expression vector.
    Type: Grant
    Filed: November 23, 1993
    Date of Patent: November 19, 1996
    Assignee: Eli Lilly and Company
    Inventors: Rama M. Belagaje, Charles L. Hershberger, Hansen M. Hsiung, Paul R. Rosteck, Jr., Jane L. Sterner
  • Method for conferring bacteriophage resistance to bacteria
    Patent number: 4732859
    Abstract: A novel method for protecting a bacterium from a naturally occurring bacteriophage and the cloning vectors and transformants for carrying out the aforementioned method are disclosed.
    Type: Grant
    Filed: September 5, 1984
    Date of Patent: March 22, 1988
    Assignee: Eli Lilly and Company
    Inventors: Charles L. Hershberger, Paul R. Rosteck, Jr.
  • Method for stabilizing and selecting recombinant DNA containing host cell
    Patent number: 4650761
    Abstract: The present invention is an improvement in the method for stabilizing and selecting host cells containing recombinant DNA. The method involves transforming a host cell with a recombinant DNA cloning vector which contains the .about.2.5 kb BglII cI repressor gene-containing restriction fragment of bacteriophage .lambda. and then lysogenizing the transformed host cell with a lysogenic organism which contains a marker which is lethal or conditionally lethal in the host cell but which is repressed in the transformed host cell by the repressor gene contained in the recombinant DNA cloning vector. The vector additionally contains a gene which codes for the expression of human proinsulin. The invention further comprises related recombinant DNA cloning vectors, transformed host cells and lysogenized transformed host cells.
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: March 17, 1987
    Assignee: Eli Lilly and Company
    Inventors: Charles L. Hershberger, Paul R. Rosteck, Jr.
  • Method for conferring bacteriophage resistance to bacteria
    Patent number: 4530904
    Abstract: A novel method for protecting a bacterium from a naturally occurring bacteriophage and the cloning vectors and transformants for carrying out the aforementioned method are disclosed.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: July 23, 1985
    Assignee: Eli Lilly and Company
    Inventors: Charles L. Hershberger, Paul R. Rosteck, Jr.
  • Stabilizing and selecting recombinant DNA host cells
    Patent number: 4506013
    Abstract: A method for stabilizing and selecting host cells containing recombinant DNA which expresses a functional polypeptide and the novel organisms and cloning vectors for the practice thereof. The invention further provides a simple, convenient, and inexpensive method to lyse host cells for purification of intracellular products.
    Type: Grant
    Filed: June 18, 1981
    Date of Patent: March 19, 1985
    Assignee: Eli Lilly and Company
    Inventors: Charles L. Hershberger, Anna K. Radue, Paul R. Rosteck, Jr.
  • Method for stabilizing and selecting recombinant DNA containing host cells
    Patent number: 4436815
    Abstract: An improved method for stabilizing and selecting host cells containing recombinant DNA which expresses a functional polypeptide and the novel organisms and cloning vectors for the practice thereof.
    Type: Grant
    Filed: November 27, 1981
    Date of Patent: March 13, 1984
    Assignee: Eli Lilly and Company
    Inventors: Charles L. Hershberger, Paul R. Rosteck, Jr.
  • Penicillin binding protein from Streptococcus pneumoniae
    Patent number: H2085
    Abstract: The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: October 7, 2003
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, S. Richard Jaskunas, Jr., Genshi Zhao, Pamela K. Rockey, Paul R. Rosteck, Jr., Franklin H. Norris