Abstract: The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, proteins encoded thereby, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, and methods for treating a cell using such nucleic acids or proteins.

Abstract: A media server for use in networks where media are transmitted in packet form comprises at least one card shelf containing at least one bus controller card, at least one other card such as a media processor card, and a backplane. The backplane includes a media bus group. Each packet has a routing header added to it. The data is optionally sent over a single media bus to a single card, or to a plurality of different cards. Framing information and clock pulse strings are passed to each card over the backplane. Each card is assigned an address, so that data sent from each card has a source address which is identified each time that card wishes to send data elsewhere. Also, data that is being addressed to each card will include the respective destination address of that card in its routing header. A failed card or bus can be sensed and isolated by the bus controller card, and packets will continue to be transmitted to the remaining cards over the remaining buses.

Abstract: Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular response to DNA damage comprises contacting a chemical compound to be tested with a biochemical mixture containing an isolated mammalian Mus81-Eme1 endonuclease complex, a source of magnesium ion, and a suitable DNA substrate; measuring the activity level of mammalian Mus81-Eme endonuclease complex in the mixture; comparing the measured activity level to the activity level of a substantially similar mixture of isolated Mus81-Eme1 endonuclease, magnesium ion, and DNA substrate in the absence of the chemical compound to be tested; and selecting a chemical compound that increases or decreases the endonuclease activity. Isolated mammalian Eme1 and Eme2 proteins derived from humans and murine species and isolated nucleic acids encoding the proteins are also described.

Abstract: The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.

Abstract: A media server for use in networks where media are transmitted in packet form comprises at least one card shelf containing at least one bus controller card, at least one other card such as a media processor card, and a backplane. The backplane includes a media bus group. Each packet has a routing header added to it. The data is optionally sent over a single media bus to a single card, or to a plurality of different cards. Framing information and clock pulse strings are passed to each card over the backplane. Each card is assigned an address, so that data sent from each card has a source address which is identified each time that card wishes to send data elsewhere. Also, data that is being addressed to each card will include the respective destination address of that card in its routing header. A failed card or bus can be sensed and isolated by the bus controller card, and packets will continue to be transmitted to the remaining cards over the remaining buses.

Abstract: The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.

Abstract: A multidimensional equilateral angular game playing apparatus and method include electronically controlled, life-sized obelisk "opponents" in the vertex of each angle. A sound generator and multiple lighted targets are mounted upon variously angled surfaces of each obelisk so that a target becomes momentarily active when its light is illuminated and a sound generator mounted upon the obelisk holding the target is actuated. The sequence of targets presented to a player and the time duration of each activation may be selected in a random manner by electronic controls. A single player strikes activated targets using thrusting and sweeping motions of a double-sided, padded playing staff. Upon successfully striking a target, the sound generator upon which obelisk the target is mounted emits a tone verifying the success of the strike, a point is added to a total sum of successful strikes, the target is deactivated and the next target is immediately presented to the player.

Abstract: A lead straightening and trimming apparatus for the leads of electrical components such as stators. The apparatus includes a pallet having positioning posts which position the stators on the pallet and also position coils within the stator. The apparatus also includes a rotating helical pick-up tool which is movable between a retracted position and an extended position adjacent to a component supporting pallet having lead retaining posts. The pick-up tool operates to capture the free ends of leads extending from posts provided by the pallets. Upon retraction, the pick-up tool moves the associated free ends of the leads to a partially straightened gripping position. The apparatus also includes a combined gripper straightening and cutting apparatus which grips the associated lead adjacent to the pallet post with a force insufficient to cut the lead. Retraction of the gripper straightens the portion of the lead extending from the retaining post of the pallet.

Abstract: Transfer and inserter tooling for receiving coil windings from a coil winder such as a shed winder, and for inserting the coils into a dynamoelectric component such as a motor stator. The tooling includes a transfer tool molded of plastic and providing a cylindrical array of cantilever-supported fingers. The coils formed on the winder are positioned in a predetermined arrangement within the spaces between the fingers. Also included is an inserter tool having a cylindrical array of cantilever-mounted fingers and operable to insert coils positioned within the spaces between the fingers into the slots of a stator and the like. The transfer tool and inserter tool fingers are provided with interfitting alignment and guide means which properly position associated fingers of the two tools when the tools are assembled for transfer of the coils from the transfer tool to the inserter tool.