Abstract: Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein. Also provided are compositions, methods, and kits for using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection.

Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.

Abstract: Systems and methods are described for detecting and identifying discrepancies of states of objects and/or areas of interest in a space. In some aspects, an autonomous device may collect ground truth data of a space including information identifying objects each associated with a location in the space, and a condition associated with at least some of the objects. A checklist including a set of desired states for at some of objects may be obtained and compared to the ground truth data to produce a set of comparisons, where individual comparisons identify discrepancies between the ground truth data of an object and the desired state of the object. The discrepancies may be compared to a criteria for correction, and upon at least one satisfying the criteria, a notification indicating the at least one discrepancy may generated and/or performance of a corrective action triggered.

Abstract: Systems and methods are described for disinfecting a space, such as an interior room. In some aspects, at least one object in the space may be identified, such as by a mobile disinfecting device (device) including an ultraviolet lamp. Next, the object(s) may be categorizing as a certain type based on whether the object allows some light to pass through or around it. A route for the device may be determined, where the route includes a path and speed of the device corresponding to different segments of the path to yield a dosage score (ultraviolet exposure) that meets or exceeds a threshold value for different areas of the space. In some cases, determining the route further includes determining at least one of a speed, a modified path, or an ultraviolet radiation characteristic for at least one segment of the path based on the categorization of the object(s).

Abstract: In embodiments, an optoelectronic apparatus may include a substrate with a first side and a second side opposite the first side; a photodetector disposed on the first side of the substrate, the photodetector to convert a light signal into an electrical signal; and a dielectric metasurface lens etched into the second side of the substrate, the dielectric metasurface lens to collect incident light and focus it through the substrate onto the photodetector.

Abstract: The invention provides methods of diagnosing autism spectrum disorders (ASD) by analyzing ratios of concentrations of selected amine containing compounds in a sample, such as a blood sample, from a subject. Based on the discovery that specific amine containing compounds and their ratios are dysregulated in patients with ASD, these metabotypes or subtypes of metabolism have the potential to diagnose earlier and suggest more precise treatment based on the metabolism of the individual. The invention provides methods of analyzing amine containing compounds and ratios in a test subject and determining whether the test subject has or is at risk of developing an ASD by comparing ratios from the test subject to ratios from subjects diagnosed with a neurodevelopmental disorder such as ASD who share a common profile of metabolism which is not found in the majority of typically developing subjects.

Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.

Abstract: This present invention provides rapid, reproducible, biomarker-based screening methods for the developmental toxicity testing of compounds. The methods are designed to identify the exposure level at which a test compound perturbs metabolism in a manner predictive of developmental toxicity. In particular, the perturbation of two metabolites, ornithine and cystine, is measured, wherein a ratio of the fold change in ornithine to the fold change in cystine of less than or equal to about 0.88 is indicative of the teratogenicity of a test compound.

Abstract: In embodiments, an optoelectronic apparatus may include a substrate with a first side and a second side opposite the first side; a photodetector disposed on the first side of the substrate, the photodetector to convert a light signal into an electrical signal; and a dielectric metasurface lens etched into the second side of the substrate, the dielectric metasurface lens to collect incident light and focus it through the substrate onto the photodetector.

Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.

Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.

Abstract: A micro-lens enhanced element comprises a substrate bearing sequences of printed image elements, each sequence containing image elements from more than one image. A transparent spacer layer is coated over the interlaced image strips. Lenticular lenses are fashioned over each sequence of image elements by deposition of a transparent layer of low surface energy polydimethyl siloxane based material and ablation of the same to create strips of material abhesive to a polymeric lens forming material between consecutive sequences of printed image elements. During deposition of a liquid lens forming material, the liquid withdraws from the liquid abhesive low surface energy strips to form a meniscus, thereby providing lenticular lenses. The transparent low surface energy material comprises a near infrared dye with low absorption in the visible range of the spectrum to render the material both transparent and ablateable by infrared laser.

Abstract: A negative-working lithographic printing plate precursor can be imaged with infrared radiation and processed in a single step using a single processing solution having a pH of from about 3 to 11. The precursor has a primary polymeric binder that comprises recurring units derived from one or more N-alkoxymethyl(meth)acrylamides, provided that such recurring units are present in the primary polymeric binder in an amount of at least 10% based on the total dry primary polymeric binder weight. In addition, the primary polymeric binder is present in an amount of from about 12 to about 70% based on total imageable layer dry weight. The imaged precursor can be processed off-press or on-press.

Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.

Abstract: A micro-lens enhanced element comprises a substrate bearing sequences of printed image elements, each sequence containing image elements from more than one image. A transparent spacer layer is coated over the interlaced image strips. Lenticular lenses are fashioned over each sequence of image elements by deposition of a transparent layer of low surface energy polydimethyl siloxane based material and ablation of the same to create strips of material adhesive to a polymeric lens forming material between consecutive sequences of printed image elements. During deposition of a liquid lens forming material, the liquid withdraws from the liquid adhesive low surface energy strips to form a meniscus, thereby providing lenticular lenses. The transparent low surface energy material comprises a near infrared dye with low absorption in the visible range of the spectrum to render the material both transparent and ablateable by infrared laser.

Abstract: A micro-lens enhanced element comprises a substrate bearing sequences of printed image elements, each sequence containing image elements from more than one image. A transparent spacer layer is coated over the interlaced image strips. Lenticular lenses are fashioned over each sequence of image elements by deposition of a transparent layer of low surface energy polydimethyl siloxane based material and ablation of the same to create strips of material abhesive to a polymeric lens forming material between consecutive sequences of printed image elements. During deposition of a liquid lens forming material, the liquid withdraws from the liquid abhesive low surface energy strips to form a meniscus, thereby providing lenticular lenses. The transparent low surface energy material comprises a near infrared dye with low absorption in the visible range of the spectrum to render the material both transparent and ablateable by infrared laser.

Abstract: A micro-lens enhanced element comprises a substrate bearing sequences of printed image elements, each sequence containing image elements from more than one image. A transparent spacer layer is coated over the interlaced image strips. Lenticular lenses are fashioned over each sequence of image elements by deposition of a transparent layer of low surface energy polydimethyl siloxane based material and ablation of the same to create strips of material adhesive to a polymeric lens forming material between consecutive sequences of printed image elements. During deposition of a liquid lens forming material, the liquid withdraws from the liquid adhesive low surface energy strips to form a meniscus, thereby providing lenticular lenses. The transparent low surface energy material comprises a near infrared dye with low absorption in the visible range of the spectrum to render the material both transparent and ablateable by infrared laser.

Abstract: A micro-lens enhanced element comprises a substrate bearing sequences of printed image elements, each sequence containing image elements front more than one image. A transparent spacer layer is coated over the interlaced image strips. Lenticular lenses are fashioned over each sequence of image elements by deposition of a transparent layer of low surface energy polydimethyl siloxane based material and ablation of the same to create strips of material abhesive to a polymeric lens forming material between consecutive sequences of printed image elements. During deposition of a liquid lens forming material, the liquid withdraws from the liquid abhesive low surface energy strips to form a meniscus, thereby providing lenticular lenses. The transparent low surface energy material comprises a near infrared dye with low absorption in the visible range of the spectrum to render the material both transparent and ablateable by infrared laser.

Abstract: A micro-lens enhanced element comprises a substrate bearing sequences of printed image elements, each sequence containing image elements from more than one image. A transparent spacer layer is coated over the interlaced image strips. Lenticular lenses are fashioned over each sequence of image elements by deposition of a transparent layer of low surface energy polydimethyl siloxane based material and imagewise conversion of the same to create strips of material abhesive to a polymeric lens forming material between consecutive sequences of printed image elements. During deposition of a liquid lens forming material, the liquid withdraws from the liquid abhesive low surface energy strips to form a meniscus, thereby providing lenticular lenses. The transparent low surface energy material comprises a near infrared dye with low absorption in the visible range of the spectrum to render the material both transparent and convertible by infrared laser.

Abstract: A negative-working lithographic printing plate precursor can be imaged with infrared radiation and processed in a single step using a single processing solution having a pH of from about 3 to 11. The precursor has a primary polymeric binder that comprises recurring units derived from one or more N-alkoxymethyl(meth)acrylamides, provided that such recurring units are present in the primary polymeric binder in an amount of at least 10% based on the total dry primary polymeric binder weight. In addition, the primary polymeric binder is present in an amount of from about 12 to about 70% based on total imageable layer dry weight. The imaged precursor can be processed off-press or on-press.