Patent number: 6326500
Abstract: Compounds of formula (I)
and salts thereof, wherein
R1 is hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, —NR13R14, —N(R15)SO2R16, haloalkoxy, haloalkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, —SOnR7, alkoxycarbonylalkyl, carboxylalkyl, —CONR11R12, carbamoylvinyl, —O—SO2R21, 4,5-dihydrothiazol-2-yl, 4,4-dimethyl-2-oxazolin-2-yl, —NR60R61 or —(O)z—L3—G (G=−NR22R23, —SOmR26, CONR27R28 or —OR29);
R2 and R3 are independently hydrogen halo, alkyl, alkoxy, —NR13R14, haloalkoxy, haloalkyl, hydroxy, —SOnR7 or —NR60R61;
L1 is a bond, alkylene, cycloalkylene or cycloalkylidene;
T is a bond, O, S, SO, SO2, CO or 1,3-dioxolan-2-ylidene;
L2 is alkylene, cycloalkylene or cycloalkylidene;
R6 is hydrogen or alkyl;
Q is alkylene; and
Y is imidazolyl,
which are antiinflammatory, antiallergic and immunodulant agents.
Type:
Grant
Filed:
December 27, 2000
Date of Patent:
December 4, 2001
Assignee:
Abbott Laboratories
Inventors:
David John Calderwood, Adrian John Fisher, James Edward Jeffery, Colin Gerhart Pryce Jones, Paul Rafferty
Patent number: 6215001
Abstract: Compounds of the formula I
and pharmaceutically acceptable salts thereof in which R1 represents hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, —NR13R14, —N(R15)SO2R16, halogenated alkoxy, halogenated alkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, —S(O)nR7, alkoxycarbonylalkyl, carboxyalkyl, —CONR13R12 carbamoylvinyl, —OSO2R21, 4,5-dihydrothiazol-2-yl, 4,4-dimethyl-2-oxazolin-2-yl or —NR60R61; or R1 represents a group of formula —(O)z—L3G wherein z equals 0 or 1, L3 represents a C1-4 alkylene chain, G represents a group of formula a), b), c), or d): a) —NR22R23; b) —S(O)mR26; c) CONR27R28; d) —OR29; R2 and R3 independently represent hydrogen, halo, alkyl, alkoxy, —NR13R14, halogenated alkoxy, halogenated alkyl, hydroxy, —S(O)nR7 or —NR60R61; L1 represents e) a bond, or f) alkylene, cycloalkylene or cycloalkylidene; T represents a bond or O, S, SO, SO2, a carbo
Type:
Grant
Filed:
October 7, 1999
Date of Patent:
April 10, 2001
Assignee:
Knoll Aktiengesellschaft
Inventors:
David John Calderwood, Adrian John Fisher, James Edward Jeffery, Colin Gerhart Pryce Jones, Paul Rafferty
Patent number: 5780642
Abstract: Compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof in which R.sub.1 represents hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, --NR.sub.13 R.sub.14, --N(R.sub.15)SO.sub.2 R16, halogenated alkoxy, halogenated alkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, --S(O).sub.n R.sub.7, alkoxycarbonylalkyl, carboxyalkyl, --CONR.sub.11 R.sub.12 carbamoylvinyl, --OSO.sub.2 R.sub.21, 4,5-dihydrothiazol-2-yl, 4,4-dimethyl-2-oxazolin-2-yl or --NR.sub.60 R.sub.61 ; or R.sub.1 represents a group of formula --(O).sub.z --L.sub.3 G wherein z equals 0 or 1, L.sub.3 represents a C.sub.1-4 alkylene chain, G represents a group of formula a), b), c), or d): a) --NR.sub.22 R.sub.23 ; b) --S(O).sub.m R.sub.26 ; c) CONR.sub.27 R.sub.28 ; d) --OR.sub.29 ; R.sub.2 and R.sub.3 independently represent hydrogen, halo, alkyl, alkoxy, --NR.sub.13 R.sub.14, halogenated alkoxy, halogenated alkyl, hydroxy, --S(O).sub.n R.sub.7 or --NR.sub.60 R.sub.61 ; L.sub.
Type:
Grant
Filed:
January 23, 1997
Date of Patent:
July 14, 1998
Assignee:
KNOLL Aktiengesellschaft
Inventors:
David John Calderwood, Adrian John Fisher, James Edward Jeffery, Colin Gerhart Pryce Jones, Paul Rafferty