Patents by Inventor Paul Reginato

Paul Reginato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11180804
    Abstract: The present invention provides methods for analyzing polynucleotides such as genomic DNA. In some embodiments, the disclosure provides a method for preparing and amplifying a genomic DNA library in situ in a fixed biological sample. The method comprises treating a fixed biological sample with an insertional enzyme complex to produce tagged fragments of genomic DNA. The method further comprises circularizing the tagged fragments of genomic DNA. The method further comprises amplifying the tagged fragments of genomic DNA.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: November 23, 2021
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Fei Chen, Andrew C. Payne, Jason D. Buenrostro, Paul Reginato, Edward Stuart Boyden, Shahar Alon
  • Publication number: 20190032128
    Abstract: The present invention provides methods for analyzing polynucleotides such as genomic DNA. In some embodiments, the disclosure provides a method for preparing and amplifying a genomic DNA library in situ in a fixed biological sample. The method comprises treating a fixed biological sample with an insertional enzyme complex to produce tagged fragments of genomic DNA. The method further comprises circularizing the tagged fragments of genomic DNA. The method further comprises amplifying the tagged fragments of genomic DNA.
    Type: Application
    Filed: July 24, 2018
    Publication date: January 31, 2019
    Inventors: Fei Chen, Andrew C. Payne, Jason D. Buenrostro, Paul Reginato, Edward Stuart Boyden