Abstract: Biologically active oxidized variants of granulocyte-macrophage colony stimulating factor (GM-CSF) are provided in which one or more methionine residues are oxidized. Methods are also provided for making and characterizing such variants.

Abstract: A crystal forming device includes a base plate having a plurality of wells therein, each well adapted to receive a reservoir solution therein and each well having a bottom and a circumferential side wall connected With the bottom to define a chamber therein, the side wall having an upper circumferential edge defining an upper opening of the well; a single removable cover for covering all of the wells, the single removable cover having a lower surface which rests on the upper circumferential edges of the wells to seal the wells and to thereby seal the chambers, the cover having a plurality of circular beads formed on the lower surface thereof, the circular beads corresponding in position to the upper circumferential edges of the wells and the circular beads extending in surrounding relation to respective the upper circumferential edges when the cover is positioned on the base plate; and a silicon grease applied to the upper circumferential edges for sealing the lower surface of the single removable cover to ea

Abstract: This invention provides a crystalline form of recombinant human granulocyte-macrophage colony-stimulating factor (r-h-GM-CSF) and methods for making such crystals.