Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: Methods and apparatus to control the actuation of regulators including a loading chamber are disclosed. An example apparatus includes a first pneumatic regulator including a loading chamber, the first pneumatic regulator to flow fluid toward a downstream process; a second pneumatic regulator coupled between the loading chamber and the downstream process, the second pneumatic regulator to control an actuation of the first pneumatic regulator during normal operation based on a pressure difference between a first pressure downstream of the first pneumatic regulator and a second pressure within the loading chamber; and a valve coupled between the loading chamber and the downstream process, the valve to control the actuation of the first pneumatic regulator during a shut-down event.

Abstract: Methods and apparatus to control the actuation of regulators including a loading chamber are disclosed. An example apparatus includes a first pneumatic regulator including a loading chamber, the first pneumatic regulator to flow fluid toward a downstream process; a second pneumatic regulator coupled between the loading chamber and the downstream process, the second pneumatic regulator to control an actuation of the first pneumatic regulator during normal operation based on a pressure difference between a first pressure downstream of the first pneumatic regulator and a second pressure within the loading chamber; and a valve coupled between the loading chamber and the downstream process, the valve to control the actuation of the first pneumatic regulator during a shut-down event.

Abstract: A fluid regulating device includes a regulator valve, an actuator and a pilot regulator valve assembly. The pilot regulator valve assembly provides a pressure load to a surface of a diaphragm of the actuator in response to changes in downstream pressure being applied to the opposite surface of the diaphragm. An upper cavity of the pilot regulator valve assembly is in fluid communication with a control cavity of the actuator, allowing both the actuator diaphragm and the pilot regulator valve assembly diaphragm to simultaneously sense pressure variations within the cavities. As the downstream pressure varies, the diaphragms of both the actuator and the pilot regulator valve assembly displace to regulate the downstream pressure and the pilot regulator valve assembly maintains a load pressure. The regulator further includes a balanced regulator valve applying a balancing force to offset a force of upstream pressure on a balanced valve plug.

Abstract: A fluid regulating device includes a regulator valve, an actuator and a pilot regulator valve assembly. The pilot regulator valve assembly provides a pressure load to a surface of a diaphragm of the actuator in response to changes in downstream pressure being applied to the opposite surface of the diaphragm. An upper cavity of the pilot regulator valve assembly is in fluid communication with a control cavity of the actuator, allowing both the actuator diaphragm and the pilot regulator valve assembly diaphragm to simultaneously sense pressure variations within the cavities. As the downstream pressure varies, the diaphragms of both the actuator and the pilot regulator valve assembly displace to regulate the downstream pressure and the pilot regulator valve assembly maintains a load pressure. The regulator further includes a balanced regulator valve applying a balancing force to offset a force of upstream pressure on a balanced valve plug.

Abstract: Apparatus to configure fluid regulators are described. In one example, a stem guide for use with a fluid regulator is described. The stem guide includes a body having an opening to slidably receive a valve stem and an outer surface having a plurality of circumferential seals that removably couple the body within a bore of a regulator casing and align the body with the regulator casing or a valve.

Abstract: Apparatus to configure fluid regulators are described. In one example, a stem guide for use with a fluid regulator is described. The stem guide includes a body having an opening to slidably receive a valve stem and an outer surface having a plurality of circumferential seals that removably couple the body within a bore of a regulator casing and align the body with the regulator casing or a valve.