Patents by Inventor Paul Robert Eastwood

Paul Robert Eastwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds active towards nuclear receptors
    Patent number: 11780843
    Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: October 10, 2023
    Assignee: NUEVOLUTION A/S
    Inventors: Sanne Schrøder Glad, Ian Sarvary, Alex Haahr Gouliaev, Thomas Franch, Luigi Piero Stasi, Montserrat Erra Solà, Joan Taltavull Moll, Paul Robert Eastwood
  • COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
    Publication number: 20220363683
    Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
    Type: Application
    Filed: March 31, 2021
    Publication date: November 17, 2022
    Inventors: Sanne Schrøder Glad, Ian Sarvary, Alex Haahr Gouliaev, Thomas Franch, Luigi Piero Stasi, Montserrat Erra Solà, Joan Taltavull Moll, Paul Robert Eastwood
  • Substituted pyrazolo[1,5-a]pyridines as JAK inhibitors
    Patent number: 9206183
    Abstract: New pyrazole derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: December 8, 2015
    Assignee: ALMIRALL, S.A.
    Inventors: Jordi Bach Taña, Lluis Miquel Pages Santacana, Joan Taltavull Moll, Paul Robert Eastwood, Jacob Gonzalez Rodrigues, Victor Giulio Matassa
  • Pyridin-2(1 H)-one derivatives as JAK inhibitors
    Patent number: 9034311
    Abstract: New pyridin-2(1H)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: May 19, 2015
    Assignee: ALMIRALL, S.A.
    Inventors: Paul Robert Eastwood, Jordi Bach Taña, Lluis Miquel Pages Santacana
  • PYRAZOLE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20150118186
    Abstract: New pyrazole derivatives having the chemical structure of formula (I) are disclosed; as well as process for theft preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
    Type: Application
    Filed: January 5, 2015
    Publication date: April 30, 2015
    Inventors: Jordi BACH TAÑA, Lluis Miquel PAGES SANTACANA, Joan TALTAVULL MOLL, Paul Robert EASTWOOD, Jacob GONZALEZ RODRIGUES, Victor GIULIO MATASSA
  • PYRIDIN-2(1H)-ONE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20140271543
    Abstract: New pyridin-2(1H)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
    Type: Application
    Filed: July 23, 2012
    Publication date: September 18, 2014
    Applicant: ALMIRALL, S.A.
    Inventors: Paul Robert Eastwood, Jordi Bach Taña, Lluis Miquel Pages Santacana
  • Substituted spiro[cycloalkyl-1,3?-indo]-2?(1?H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors
    Patent number: 8772288
    Abstract: The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: July 8, 2014
    Assignee: Almirall, S.A.
    Inventors: Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Bernet Vidal Juan, Nuria Aguilar Izquierdo
  • PYRIDIN-2(1H)-ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES
    Publication number: 20140170110
    Abstract: Compounds having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
    Type: Application
    Filed: May 21, 2012
    Publication date: June 19, 2014
    Applicant: ALMIRALL, S.A.
    Inventors: Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Elena Gomez Castillo, Jordi Bach Taña
  • PYRAZOLE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20140086870
    Abstract: New pyrazole derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
    Type: Application
    Filed: February 18, 2011
    Publication date: March 27, 2014
    Inventors: Jordi Bach Taña, Lluis Miquel Pages Santacana, Joan Taltavull Moll, Paul Robert Eastwood, Jacob Gonzalez Rodrigues, Victor Giulio Matassa
  • IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20130216498
    Abstract: New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
    Type: Application
    Filed: December 23, 2010
    Publication date: August 22, 2013
    Inventors: Paul Robert Eastwood, Jacob Gonzales Rodriguez, Jordi Bach Taña, Lluis Miquel Pages Santacana, Joan Taltavull Moll, Juan Francisco Caturla Javaloyes, Victor Giulio Matassa
  • PYRAZOLE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20130209400
    Abstract: New pyrazole derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
    Type: Application
    Filed: February 18, 2011
    Publication date: August 15, 2013
    Inventors: Jordi Bach Taña, Lluis Miquel Pages Santacana, Joan Taltavull Moll, Paul Robert Eastwood, Jacob Gonzalez Rodrigues, Victor Giulio Matassa
  • Substituted indolin-2-one derivatives and their use as P38 mitogen-activated kinase inhibitors
    Patent number: 8450341
    Abstract: The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: May 28, 2013
    Assignee: Almirall, S.A.
    Inventors: Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Victor Giulio Matassa
  • HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20130089512
    Abstract: New heteroaryl imidazolone derivatives having the chemical structure of formula (I) are disclosed, as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
    Type: Application
    Filed: June 14, 2011
    Publication date: April 11, 2013
    Inventors: Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Elena Gomez Castillo, Jordi Bach Taña
  • 4,8-diphenyl-polyazanaphthalene derivatives
    Patent number: 8334294
    Abstract: New inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) are disclosed herein, as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: December 18, 2012
    Assignee: Almirall, S.A.
    Inventors: Wenceslao Lumeras Amador, Paul Robert Eastwood
  • 3-([1,2,4]triazolo[4,3-a]pyridin-7-yl)benzamide derivatives
    Patent number: 8258122
    Abstract: New inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) are disclosed herein, as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: September 4, 2012
    Assignee: Almirall, S.A.
    Inventors: Bernat Vidal Juan, Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Cristina Esteve Trias
  • Substituted AZA-indoles as inhibitors of poly(ADP-ribose) polymerase (PARP)
    Patent number: 8008491
    Abstract: The present invention relates to a series of substituted aza-indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: August 30, 2011
    Assignee: Aventis Pharmaceuticals, Inc.
    Inventors: John Ziqi Jiang, Jack Roger Koehl, Shujaath Mehdi, Neil Moorcroft, Kwon Yon Musick, Philip Marvin Weintraub, Paul Robert Eastwood
  • SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS
    Publication number: 20110053936
    Abstract: The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 3, 2009
    Publication date: March 3, 2011
    Inventors: Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Bernat Vidal Juan, Nuria Aguilar Izquierdo
  • SUBSTITUTED INDOLIN-2-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS
    Publication number: 20110046097
    Abstract: The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 16, 2009
    Publication date: February 24, 2011
    Inventors: Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Victor Giulio Matassa
  • Imidazopyridine derivatives as Aadenosine receptor antagonists
    Patent number: 7855202
    Abstract: The present disclosure relates to imidazopyridine derivatives of formula (I): The present disclosure also relates to a method for treating a subject afflicted with a pathological condition or disease susceptible to amelioration by antagonism of the A2B adenosine receptor.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: December 21, 2010
    Assignee: Laboratorios Almirall, S.A.
    Inventors: Bernat Vidal Juan, Silvia Fonquerna Pou, Paul Robert Eastwood, Jose Aiguade Bosch, Aranzazu Cardus Figueras, Ines Carranco Moruno, Jacob Gonzalez Rodriguez, Sergio Paredes Aparicio
  • PYRAZINE DERIVATIVES USEFUL AS ADENOSINE RECEPTOR ANTAGONISTS
    Publication number: 20100273757
    Abstract: The present invention provides a compound of formula (I) wherein: A represents an optionally substituted monocyclic or polycyclic aryl or heteroaryl group B represents an optionally substituted monocyclic nitrogen-containing heteroaryl group; and either a) R1 and R2 represent hydrogen or specified substituents, or b) R2, R1 and the —NH— group to which R1 is attached, form a moiety selected from the moiety of formulae (IIa) and (IIb): (IIa) These compounds are useful as antagonists of the A2B receptor, for instance in the treatment of asthma.
    Type: Application
    Filed: June 4, 2010
    Publication date: October 28, 2010
    Inventors: Bernat Vidal Juan, Cristina Esteve Trias, Lidia Soca Pueyo, Paul Robert Eastwood