Patents by Inventor Paul Roepman

Paul Roepman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Means and methods for molecular classification of breast cancer
    Patent number: 10072301
    Abstract: The invention relates to a method of typing a sample from a breast cancer patient. More specifically, the invention relates to a method for classification of breast cancer according to the presence or absence of Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal growth factor Receptor 2 (ERBB2; HER2). More specifically, the invention provides methods and means to classify breast cancer as ER positive, triple negative (ER?, PR? and HER2?) and HER2+.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: September 11, 2018
    Assignee: Agendia N.V.
    Inventors: Oscar Krijgsman, Paul Roepman, Annuska Maria Glas
  • Methods and means for molecular classification of colorectal cancers
    Patent number: 10036070
    Abstract: The invention relates to methods of typing a sample from a colorectal cancer patient based on the levels of RNA expression products in a cancer cell of the patient. The invention further relates to methods for determining a strategy for treatment of a patient suffering from colorectal cancer, and to methods for assigning treatment to a patient suffering from colorectal cancer.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: July 31, 2018
    Assignee: AGENDIA N.V.
    Inventors: Paul Roepman, Iris Simon, Tian Sun
  • Method and Means for Typing a Sample Comprising Cancer Cells Based on Oncogenic Signal Transduction Pathways
    Publication number: 20170292162
    Abstract: The invention is related to a method of determining whether an individual suffering from cancer is likely to respond to anti-EGFR and/or EGFR pathway therapy. In one aspect, the invention utilizes the expression level of a set of genes for determining said response. In a further aspect, the invention relates to a method of assigning treatment to an individual suffering from cancer.
    Type: Application
    Filed: April 19, 2017
    Publication date: October 12, 2017
    Applicant: Agendia N.V.
    Inventors: Tian Sun, Paul Roepman, Annuska Maria Glas, Rene Bernards, Iris Simon
  • MEANS AND METHODS FOR MOLECULAR CLASSIFICATION OF BREAST CANCER
    Publication number: 20160115552
    Abstract: The invention relates to a method of typing a sample from a breast cancer patient. More specifically, the invention relates to a method for classification of breast cancer according to the presence or absence of Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal growth factor Receptor 2 (ERBB2; HER2). More specifically, the invention provides methods and means to classify breast cancer as ER positive, triple negative (ER?, PR? and HER2?) and HER2+.
    Type: Application
    Filed: October 28, 2015
    Publication date: April 28, 2016
    Inventors: Oscar Krijgsman, Paul Roepman, Annuska Maria Glas
  • Means and methods for molecular classification of breast cancer
    Patent number: 9175351
    Abstract: The invention relates to a method of typing a sample from a breast cancer patient. More specifically, the invention relates to a method for classification of breast cancer according to the presence or absence of Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal growth facto Receptor 2 (ERBB2; HER2). More specifically, the invention Provides methods and means to classify breast cancer as ER positive, triple negative (ER?, PR? and HER2?) and HER2+.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: November 3, 2015
    Assignee: AGENDIA N.V.
    Inventors: Oscar Krijgsman, Paul Roepman, Annuska Maria Glas
  • METHODS AND MEANS FOR PREDICTING RESISTANCE TO ANTI-CANCER TREATMENT
    Publication number: 20150275306
    Abstract: The present invention relates to methods of typing a sample from an individual suffering from cancer. The invention further relates to methods for assigning treatment to an individual suffering from cancer, comprising typing a sample from an individual suffering from cancer according to the methods of the invention.
    Type: Application
    Filed: October 10, 2013
    Publication date: October 1, 2015
    Inventors: Rene Bernards, Paul Roepman, Sidong Huang
  • Prognostic gene expression signature for non small cell lung cancer patients
    Patent number: 8969000
    Abstract: The invention relates to a method of typing non-small cell lung cancer by determining RNA levels for a set of genes. The typing can be used for determining a metastasizing potential of the cancer cells. The invention further relates to a set of probes and a set of primers for typing non-small cell cancer cells.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: March 3, 2015
    Assignee: Agendia B.V.
    Inventors: Paul Roepman, Nico Van Zandwijk, Annuska Maria Glas
  • Methods and means for typing a sample comprising colorectal cancer cells
    Patent number: 8921051
    Abstract: The invention relates to a method of typing colorectal cancer cells by determining the RNA levels of a set of signature genes. Said typing can be use for predicting a risk for recurrence of said colorectal cancer. The invention further relates to a set of genes that can be used for normalizing the RNA levels of said set of signature genes, and to micro-array comprising said set of signature genes.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: December 30, 2014
    Assignee: Agendia B.V.
    Inventors: Paul Roepman, Annuska Maria Glas
  • Means and method for determining tumor cell percentage in a sample
    Patent number: 8658371
    Abstract: The invention provides a method for determining the percentage of tumor cells in a sample of an individual, preferably a breast sample. More specifically, the invention provides one or more genes than can be used to determine the percentage of tumor cells. The invention further provides a set of probes, a set of primers, and uses thereof for detection of said one or more genes.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: February 25, 2014
    Assignee: Agendia B.V.
    Inventors: Paul Roepman, Annuska Maria Glas
  • Methods and Means for Typing a Sample Comprising Cancer Cells Based on Oncogenic Signal Transduction Pathways
    Publication number: 20130302321
    Abstract: The invention is related to a method of determining whether an individual suffering from cancer is likely to respond to anti-EGFR and/or EGFR pathway therapy. In one aspect, the invention utilizes the expression level of a set of genes for determining said response. In a further aspect, the invention relates to a method of assigning treatment to an individual suffering from cancer.
    Type: Application
    Filed: September 28, 2011
    Publication date: November 14, 2013
    Applicant: AGENDIA N.V.
    Inventors: Tian Sun, Paul Roepman, Annuska Maria Glas, Rene Bernards, Iris Simon
  • Methods and Means for Molecular Classification of Colorectal Cancers
    Publication number: 20130296191
    Abstract: The invention relates to methods of typing a sample from a colorectal cancer patient based on the levels of RNA expression products in a cancer cell of the patient. The invention further relates to methods for determining a strategy for treatment of a patient suffering from colorectal cancer, and to methods for assigning treatment to a patient suffering from colorectal cancer.
    Type: Application
    Filed: December 23, 2011
    Publication date: November 7, 2013
    Inventors: Paul Roepman, Iris Simon, Tian Sun
  • MEANS AND METHODS FOR MOLECULAR CLASSIFICATION OF BREAST CANCER
    Publication number: 20130178381
    Abstract: The invention relates to a method of typing a sample from a breast cancer patient. More specifically, the invention relates to a method for classification of breast cancer according to the presence or absence of Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal growth factor Receptor 2 (ERBB2; HER2). More specifically, the invention provides methods and means to classify breast cancer as ER positive, triple negative (ER?, PR? and HER2?) and HER2+.
    Type: Application
    Filed: July 11, 2012
    Publication date: July 11, 2013
    Inventors: Oscar Krijgsman, Paul Roepman, Annuska Maria Glas
  • METHODS AND MEANS FOR TYPING A SAMPLE COMPRISING COLORECTAL CANCER CELLS
    Publication number: 20110319285
    Abstract: The invention relates to a method of typing colorectal cancer cells by determining the RNA levels of a set of signature genes. Said typing can be use for predicting a risk for recurrence of said colorectal cancer. The invention further relates to a set of genes that can be used for normalizing the RNA levels of said set of signature genes, and to micro-array comprising said set of signature genes.
    Type: Application
    Filed: December 23, 2009
    Publication date: December 29, 2011
    Inventors: Paul Roepman, Annuska Maria Glas
  • MEANS AND METHOD FOR DETERMINING TUMOR CELL PERCENTAGE IN A SAMPLE
    Publication number: 20110269127
    Abstract: The invention provides a method for determining the percentage of tumor cells in a sample of an individual, preferably a breast sample. More specifically, the invention provides one or more genes than can be used to determine the percentage of tumor cells. The invention further provides a set of probes, a set of primers, and uses thereof for detection of said one or more genes.
    Type: Application
    Filed: September 1, 2009
    Publication date: November 3, 2011
    Inventors: Paul Roepman, Annuska Maria Glas
  • PROGNOSTIC GENE EXPRESSION SIGNATURE FOR NON SMALL CELL LUNG CANCER PATIENTS
    Publication number: 20100184052
    Abstract: The invention relates to a method of typing non-small cell lung cancer cells by determining RNA levels for a set of genes. Said typing can be used for determining a metastasizing potential of the cancer cells. The invention further relates to a set of probes and a set of primers that can be used for typing non-small cell lung cancer cells.
    Type: Application
    Filed: June 2, 2008
    Publication date: July 22, 2010
    Inventors: Paul Roepman, Nico van Zandwijk, Annuska Maria Glas
  • Diagnosis of Metastases in Hnscc Tumours
    Publication number: 20090005258
    Abstract: The invention relates to the detection or prediction of metastases of head and neck squamous cell carcinoma (HNSCC) with the use of gene expression profiles. A gene signature has been identified which is able to detect or predict the occurrence of these metastases better than current clinical methods. Part of the invention are micro-arrays comprising this signature and methods for performing the detection and/or prediction.
    Type: Application
    Filed: January 6, 2006
    Publication date: January 1, 2009
    Inventors: Frank Charles P. Holstege, Pieter Johannes Slootweg, Paul Roepman