Patents by Inventor Paul Roethle

Paul Roethle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240033312
    Abstract: The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.
    Type: Application
    Filed: July 14, 2023
    Publication date: February 1, 2024
    Applicant: Constance Therapeutics, Inc.
    Inventors: Constance Finley, Luke Mckee, Haley Poole Bestwick, Paul Roethle
  • Publication number: 20220031781
    Abstract: The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.
    Type: Application
    Filed: March 5, 2021
    Publication date: February 3, 2022
    Applicant: Constance Therapeutics, Inc.
    Inventors: Constance Finley, Luke Mckee, Haley Poole Bestwick, Paul Roethle
  • Patent number: 10940173
    Abstract: The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: March 9, 2021
    Assignee: CONSTANCE THERAPEUTICS, INC.
    Inventors: Constance Finley, Luke McKee, Haley Poole Bestwick, Paul Roethle
  • Publication number: 20200054701
    Abstract: The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.
    Type: Application
    Filed: August 20, 2019
    Publication date: February 20, 2020
    Applicant: Constance Therapeutics, Inc.
    Inventors: Constance Finley, Luke McKee, Haley Poole Bestwick, Paul Roethle
  • Patent number: 10406186
    Abstract: The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: September 10, 2019
    Assignee: CONSTANCE THERAPEUTICS, INC.
    Inventors: Constance Finley, Luke McKee, Haley Poole Bestwick, Paul Roethle
  • Patent number: 9738646
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: August 22, 2017
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Brandon Heath Brown, Paul Roethle
  • Patent number: 9573952
    Abstract: The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one and related compounds.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: February 21, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Darin Allen, Brandon Heath Brown, Jessica Jade Chao, Randall L. Halcomb, Paul Hrvatin, Ryan McFadden, Paul Roethle, Erwina Rudio, Hong Yang, Richard Hung Chiu Yu
  • Publication number: 20160346339
    Abstract: The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.
    Type: Application
    Filed: January 29, 2016
    Publication date: December 1, 2016
    Applicant: CONSTANCE THERAPEUTICS, INC.
    Inventors: CONSTANCE FINLEY, LUKE MCKEE, HALEY POOLE BESTWICK, PAUL ROETHLE
  • Publication number: 20160108045
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Application
    Filed: September 14, 2015
    Publication date: April 21, 2016
    Inventors: Patricia Andres, Brandon Heath Brown, Krista Marie Diaz, Yoo Joong Kim, Paul Roethle, Fang Wang, Valeriya Smolenskaya
  • Publication number: 20160075707
    Abstract: The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one and related compounds.
    Type: Application
    Filed: September 14, 2015
    Publication date: March 17, 2016
    Inventors: Darin Allen, Brandon Heath Brown, Jessica Jade Chao, Randall L. Halcomb, Paul Hrvatin, Ryan McFadden, Paul Roethle, Erwina Rudio, Hong Yang, Richard Hung Chiu Yu
  • Patent number: 9102614
    Abstract: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: August 11, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Kerim Babaoglu, Elizabeth Bacon, Kyla Bjornson, Hongyan Guo, Randall L. Halcomb, Paul Hrvatin, John O. Link, Hongtao Liu, Ryan Mcfadden, Michael L. Mitchell, Paul Roethle, James Taylor, James D. Trenkle, Randall W. Vivian, Lianhong Xu
  • Patent number: 8962652
    Abstract: The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: February 24, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Randall L. Halcomb, Paul Roethle
  • Publication number: 20130203727
    Abstract: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
    Type: Application
    Filed: July 1, 2011
    Publication date: August 8, 2013
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Kerim Babaoglu, Elizabeth Bacon, Kyla Bjornson, Hongyan Guo, Randall L. Halcomb, Paul Hrvatin, John O. Link, Hongtao Liu, Ryan McFadden, Michael L. Mitchell, Paul Roethle, James Taylor, James D. Trenkle, Randall W. Vivian, Lianhong Xu