Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: An apparatus for use in a surgical procedure for delivering a prosthetic implant comprises a flexible sleeve configured with a first end and a second end, the flexible sleeve being tapered such that a width of a region at the second end is relatively smaller than a width of a region at the first end, and an interior surface of the flexible sleeve that form an interior cavity, the interior cavity being sized to receive the prosthetic implant; one or more surface active coatings are applied to the interior cavity. The flexible sleeve is manipulatable such that when the prosthetic implant is positioned within the interior cavity, a manually applicable directional pressure in the direction of the second end causes the prosthetic implant to extrude from the second end.

Abstract: A virtual network comprising virtual machines executing at a computing environment is implemented. A software defined networking (SDN) appliance is configured to provide a connection to computing resources via a virtual network of a virtual computing environment. The SDN appliance includes a network interface card that are operable to interact with multiple field-programmable gate array (FPGA) devices are configured to be a hardware acceleration device for processing data traffic, and the FPGA device is configured to ingress a packet to a dataflow on one port and egress the packet from a different port associated with a different dataflow.

Abstract: A computer implemented method includes receiving partially created software defined network (SDN) policy state information at a backup software defined network (SDN) appliance in response to the sending of a synchronize packet to establish a connection. The state information corresponds to a state of the connection between two endpoints that include a first active SDN appliance and a second active SDN appliance. A replica of the SDN policy state information is saved at the backup SDN appliance. An update to the SDN policy state information is received in response to the sending of an acknowledgement packet. The replica of the SDN policy state information updated at the backup SDN appliance to enable the backup SDN to transition to active.

Abstract: The present invention features methods and composition directed to treating neuronal injury, CNS lesion, and/or promoting axon regeneration using a phosphine sulfide-stabilized phosphine.

Abstract: The invention provides a method for treating brain or nerve injury.

Abstract: Systems and methods for treating eating disorders using electro-physiologically active transducer intragastric balloon system (“EAT system”) are described herein. The EAT System includes an intragastric balloon that is configured to operate in a typical fashion and further modified to include an integrated electro-physiological stimulation unit. The stimulation unit is configured to generate impulses using a transducer that are suitable for stimulating sensory receptors located around the stomach. In particular, transducer transmits mechanical waves through the fluid within the IG balloon and its outer shell to any receptors of the vagus nerve system that are located in the vicinity of the IG balloon. Controlled stimulation of the vagus nerve fibers using the stimulation unit can effectively produce appetite controlling sensations of satiety beyond the typical efficacy period of an unmodified IG balloon.

Abstract: A surgical device for assisting in the placement of a prosthetic implant. One or more sheets of polymer are in the form of a conical frustum such that a proximal end is sealed and a distal end is open, with an elongated slit extending from the distal end toward the proximal end. A single opening is formed by the distal opening and the elongated slit with a set of inter-lockable fastener elements disposed along opposing sides and configured to seal the elongated slit such that the distal end remains open to allow for egress of the prosthetic implant for placement into a surgical pocket. A lubricious coating is applied to the interior cavity of the frustum in addition to one or more surface active coatings. Movement of the prosthetic implant across the one or more surface active coatings causes the coatings to provide one or more offered benefits.

Abstract: Embodiments of the present invention describe and are directed towards a disposable capsule comprising a body with an open first end and a sealed second end, the body of sufficient size to hold a desired volume of solute, and a multi-receptacle adapter at the open first end to allow the body to be affixed to a plurality of receptacles. The multi-receptacle adapter may comprise a first pressure interface and a second, integrated screw interface.

Abstract: A surgical device for assisting in the placement of a prosthetic implant within a surgical pocket of a patient such that placement minimizes tissue stress along and inside the surgical pocket. The surgical device comprises a bag shaped as a conical frustum in which a proximal end of the conical frustum is sealed and a distal end of the conical frustum is open, with an elongated slit extending from the distal end towards the proximal end. An opening formed by the distal opening and the elongated slit is sufficiently large enough to accept the prosthetic implant into the bag. According to one embodiment, an adhesive is affixed along a portion of the elongated slit to seal the elongated slit such that the distal end remains open, thereby allowing for egress of the implant from the bag and placement into the surgical pocket.

Abstract: Embodiments of the present invention describe a disposable drain bulb for the collection of fluid and other exudate. A disposable drain bulb in accordance with one embodiment comprises a drain interface with a one way valve for connection to a drain line through which the drain interface receives fluid and other exudate, the drain interface sealed with a capsule, and a drain body forming an internal reservoir into which the drain interface passes and that contains an absorbable material under vacuum while the drain interface remains in a closed state.

Abstract: A virtual network comprising virtual machines executing at a computing environment is implemented. A software defined networking (SDN) appliance is configured to provide a connection to computing resources via a virtual network of a virtual computing environment. The SDN appliance includes a network interface card that are operable to interact with multiple field-programmable gate array (FPGA) devices are configured to be a hardware acceleration device for processing data traffic, and the FPGA device is configured to ingress a packet to a dataflow on one port and egress the packet from a different port associated with a different dataflow.

Abstract: An apparatus for use in a surgical procedure for delivering a prosthetic implant comprises a flexible sleeve configured with a first end and a second end, the flexible sleeve being tapered such that a width of a region at the second end is relatively smaller than a width of a region at the first end, and an interior surface of the flexible sleeve that form an interior cavity, the interior cavity being sized to receive the prosthetic implant; one or more surface active coatings are applied to the interior cavity. The flexible sleeve is manipulatable such that when the prosthetic implant is positioned within the interior cavity, a manually applicable directional pressure in the direction of the second end causes the prosthetic implant to extrude from the second end.

Abstract: The present invention features methods and composition directed to treating neuronal injury, CNS lesion, and/or promoting axon regeneration using a phosphine sulfide-stabilized phosphine.

Abstract: Systems and methods are provided for a dual-side bi-directional optical multiplexing system includes a light receiving elements array receiving light from in an egress propagation direction from an optical fiber, arranged at a side of the optical fiber. The system also includes a light transmitting elements array emitting light in an ingress propagation direction into the optical fiber, and arranged at a second position to an opposing side of the optical fiber. The light receiving elements array and the light transmitting elements array are on dual-sides of the system with respect to the optical fiber. The system also includes bi-directional micro-optics interfacing with the optical fiber, and interfacing with the light transmitting elements array to direct light propagating in the ingress direction emitted from the light transmitting element array towards the optical fiber.

Abstract: A surgical device for assisting in the placement of a prosthetic implant. One or more sheets of polymer are in the form of a conical frustum such that a proximal end is sealed and a distal end is open, with an elongated slit extending from the distal end toward the proximal end. A single opening is formed by the distal opening and the elongated slit with a set of inter-lockable fastener elements disposed along opposing sides and configured to seal the elongated slit such that the distal end remains open to allow for egress of the prosthetic implant for placement into a surgical pocket. A lubricious coating is applied to the interior cavity of the frustum in addition to one or more surface active coatings. Movement of the prosthetic implant across the one or more surface active coatings causes the coatings to provide one or more offered benefits.

Abstract: The invention provides a method for treating brain or nerve injury.

Abstract: A surgical device for assisting in the placement of a prosthetic implant within a surgical pocket of a patient such that placement minimizes tissue stress along and inside the surgical pocket. The surgical device comprises a bag shaped as a conical frustum in which a proximal end of the conical frustum is sealed and a distal end of the conical frustum is open, with an elongated slit extending from the distal end towards the proximal end. An opening formed by the distal opening and the elongated slit is sufficiently large enough to accept the prosthetic implant into the bag. According to one embodiment, an adhesive is affixed along a portion of the elongated slit to seal the elongated slit such that the distal end remains open, thereby allowing for egress of the implant from the bag and placement into the surgical pocket.

Abstract: A hybrid optical transceiver is provided. An optical component disposed on a substrate, the optical component comprising a transmitter section and a receiver section. Transmitter section comprises a plurality of vertical cavity surface emitting laser (VCSEL) arrays communicatively coupled to a plurality of multiplexers, configured to launch multiplexed optical signals into the lowest order mode group of a multimode fiber or the lowest order mode of a single mode fiber. Receiver section comprises a photodetector array comprising a plurality of optical detectors, and configured to receive demultiplexed optical signals of unknown polarization without routing waveguides. In various embodiments, each section being independently removable from a substrate.

Abstract: A surgical device for assisting in the placement of a prosthetic implant. One or more sheets of polymer are in the form of a conical frustum such that a proximal end is sealed and a distal end is open, with an elongated slit extending from the distal end toward the proximal end. A single opening is formed by the distal opening and the elongated slit with a set of inter-lockable fastener elements disposed along opposing sides and configured to seal the elongated slit such that the distal end remains open to allow for egress of the prosthetic implant for placement into a surgical pocket. A lubricious coating is applied to the interior cavity of the frustum in addition to one or more surface active coatings. Movement of the prosthetic implant across the one or more surface active coatings causes the coatings to provide one or more offered benefits.