Patents by Inventor Paul Ryan Thompson

Paul Ryan Thompson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis and use of novel inhibitors and inactivators of protein arginine deiminases
    Patent number: 7964636
    Abstract: In one embodiment of the present disclosure, an inactivator of protein arginine deiminase 4 is disclosed. The inactivator includes: (I) and x includes F; Cl, and H, y includes OH and NH2, R includes H, an alkyl group, an alkenyl group, an alknyl group, and n is greater than 0.
    Type: Grant
    Filed: November 7, 2006
    Date of Patent: June 21, 2011
    Assignee: University of South Carolina
    Inventors: Paul Ryan Thompson, Yuan Luo
  • SYNTHESIS AND USE OF NOVEL INHIBITORS AND INACTIVATORS OF PROTEIN ARGININE DEIMINASES
    Publication number: 20090306153
    Abstract: In one embodiment of the present disclosure, an inactivator of protein arginine deiminase 4 is disclosed. The inactivator includes: (I) and x includes F; Cl, and H, y includes OH and NH2, R includes H, an alkyl group, an alkenyl group, an alknyl group, and n is greater than 0.
    Type: Application
    Filed: November 7, 2006
    Publication date: December 10, 2009
    Applicant: University of South Carolina
    Inventors: Paul Ryan Thompson, Yuan Luo
  • Methods to Identify Protein Arginine Deiminase 4 Inhibitors
    Publication number: 20090162877
    Abstract: In accordance with one embodiment of the present disclosure, a method to identify a protein arginine deiminase 4 inhibitor is disclosed. The method includes performing a competitive assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to protein arginine deiminase 4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay.
    Type: Application
    Filed: October 31, 2008
    Publication date: June 25, 2009
    Applicant: University of South Carolina
    Inventors: Paul Ryan Thompson, Bryan Knuckley