Abstract: Embodiments of a microfluidic system and method for stimulating a blast shock wave that supports a short and defined laminar flow of a liquid media solution through a microfluidic device such that sheer stress on neural tissue disposed within the microfluidic device is precisely controlled are disclosed. The microfluidic system includes a pneumatic device applies a blast shock wave having a quick rise time across a microfluidic channel of the microfluidic device. The microfluidic device includes an inlet reservoir in fluid flow communication with an outlet reservoir through the microfluidic channel. The inlet and outlet reservoirs are secured to a top structure which is attached to a bottom structure that collectively defines the microfluidic channel with a cover slip that is attached to the underside of the bottom structure.

Abstract: A device and method for simulating a blast shock wave of the type produced by explosive devices such as bombs. A pneumatic charge releases a blast shock wave along a conduit which terminates in a first outlet that communicates with the atmosphere and a second outlet that is sealed to a specimen chamber. The first outlet has a quick release valve that prevents venting of the pneumatic charge to the atmosphere until the pressure at the valve reaches a predetermined level that opens the valve. The pneumatic charge therefore initially flows through the second outlet to direct the blast into the specimen chamber, until subsequent opening of the quick release valve redirects the gas flow out of the first outlet and rapidly reduces pressure in the chamber. The blast wave closely simulates the Friedlander curve, and its effects are viewed during instead of only after the blast is completed.