Patents by Inventor Paul S Bury

Paul S Bury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 17-0-vinyl-triflates as intermediates
    Patent number: 8389714
    Abstract: A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II) is converted into a triflate of formula (III) in the presence of a base comprising a tertiary or heterocyclic amine such that the pKa of the conjugate acid at 25° C. is within the range 5.21 to 12.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: March 5, 2013
    Assignee: BTG International Limited
    Inventor: Paul S Bury
  • Process for the preparation of 17-0-vinyl-triflates as intermediates
    Patent number: 8236946
    Abstract: Process for the preparation of a compound of formula (I) as defined herein by (i) triflating a ketone of formula (II) as defined herein to form a triflate of formula (III) as defined herein and (ii) reacting the compound of the formula (III) to form a compound of the formula (I) or a pharmaceutically-acceptable salt thereof. The triflating step is conducted in the presence of a base comprising a tertiary or heterocyclic amine such that the pKa of the conjugate acid at 25° C. is within the range 5.21 to 12. The base is selected from pyridine, 2,6-lutidine, N-methylmorpholine, 1,4-diazabicyclo[2.2.2]octane (DABCO), trimethylamine, triethylamine, N,N-diisopropylethylamine (DIPEA), quinuclidine and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: August 7, 2012
    Assignee: BTG International Limited
    Inventor: Paul S Bury
  • Process for the preparation of 17-0-vinyl- triflates as intermediates
    Publication number: 20110288288
    Abstract: A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II) is converted into a triflate of formula (III) in the presence of a base comprising a tertiary or heterocyclic amine such that the pKa of the conjugate acid at 25° C. is within the range 5.21 to 12.
    Type: Application
    Filed: July 27, 2011
    Publication date: November 24, 2011
    Applicant: BTG International Limited
    Inventor: Paul S. Bury