Abstract: The present invention is directed to the anti-LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3-binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.

Abstract: The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Tri-Specific Binding Molecule is preferably characterized in possessing binding domains that permit it to immunospecifically bind to: (1) an epitope of a first Cancer Antigen, (2) an epitope of a second Cancer Antigen, and (3) an epitope of a molecule that is expressed on the surface of an immune system effector cell, and are thus capable of localizing an immune system effector cell to a cell that expresses a Cancer Antigen, so as to thereby facilitate the killing of such cancer cell.

Abstract: The present invention is directed to binding molecules that possess one or more epitope-binding sites specific for an epitope of CD137 and one or more epitope-binding sites specific for an epitope of a tumor antigen (“TA”) (e.g., a “CD137×TA Binding Molecule”). In one embodiment, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific tetravalent diabodies, that are composed of two, three, four or more than four polypeptide chains and possessing two epitope-binding sites each specific for an epitope of CD137 and two epitope-binding sites each specific for an epitope of a TA. Alternatively, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific trivalent binding molecules composed of three or more polypeptide chains and possessing one or two epitope-binding sites each specific for an epitope of CD137 and one or two epitope-binding sites each specific for an epitope of a TA.

Abstract: The present invention is directed to bispecific molecules (e.g., diabodies, bispecific antibodies, trivalent binding molecules, etc.) that possess at least one epitope-binding site that is immunospecific for an epitope of PD-1 and at least one epitope-binding site that is immunospecific for an epitope of CTLA-4 (i.e., a “PD-1×CTLA-4 bispecific molecule”). The PD-1×CTLA-4 bispecific molecules of the present invention are capable of simultaneously binding to PD-1 and to CTLA-4, particularly as such molecules are arrayed on the surfaces of human cells. The invention is directed to pharmaceutical compositions that contain such PD-1×CTLA-4 bispecific molecules, and to methods involving the use of such bispecific molecules in the treatment of cancer and other diseases and conditions. The present invention also pertains to methods of using such PD-1×CTLA-4 bispecific molecules to stimulate an immune response.

Abstract: A fuel filtration system and methods controlling, and operating a fuel filtration system. A first fuel filter head is fluidly coupled to one or more first fuel filters, a second fuel filter head is fluidly coupled to one or more second fuel filters and a selector valve is coupled to the first fuel filter head and the second fuel filter head. The selector valve includes a primary valve inlet port, a primary valve outlet port, and a movable valve body movable from a first position to a second position. The first position fluidly couples the first fuel filter head to the primary valve outlet port and fluidly decouples the second fuel filter head from the primary valve outlet port. The second position fluidly couples the second fuel filter head to the primary valve outlet port and fluidly decouples the first fuel filter head from the primary valve outlet port.

Abstract: An animal watering valve preferably includes a valve device, a check ball, a screen disc and retention tail. The valve device preferably includes a valve body, a valve stem, a retention plug, a stem o-ring and a compression spring. The valve body preferably includes a threaded shank. A valve bore is formed in the valve body to receive the valve stem. A plug bore is formed in the threaded shank. The retention plug preferably is threaded into the plug bore. The retention tail preferably includes a receiver body and an attachment shaft. The receiver body includes a ball tapered counter bore to receive the check ball and a screen counter bore to receive the screen disc. The threaded shank tap is sized to threadably receive the threaded shank of the valve body. A valve extender is used to increase a length of the animal watering valve.

Abstract: An animal watering valve that includes a housing having an internal bore having an upstream inlet and a downstream outlet. The housing includes a downstream guard and an upstream cap. The valve is actuated by deflecting a valve stem, located in the bore and accessible by the animal, to open a valve within the housing. The valve may be located in a valve cartridge retainable in the housing in a snap-fit manner. A bite-resistant shield cooperates with the valve stem to act as a barrier that prevents an animal from forcing materials between the valve stem and the guard and lodging the valve stem in its deflected or actuated position.

Abstract: An automatic animal watering system has a manifold for transporting drinking water, a controlled volume dispenser in the manifold for receiving a volume of drinking water, an inlet valve, and an outlet valve. A plurality of drinking valve assemblies is provided in fluid communication with the manifold between the inlet and outlet valves. A fluid sensor, capable of responding to changes in one or both of the water volume and pressure, is provided in the manifold between the inlet and outlet valves. The volume of drinking water available to the drinking valve assemblies can be regulated as a function of time to limit maximum potential leakage. The system also includes a controller receiving signals from the fluid sensor and generating a response to changes in the monitored water volume or pressure, thereby limiting potential water leakage in the system.

Abstract: An animal watering valve that includes a housing having an internal bore having an upstream inlet and a downstream outlet. The housing includes a downstream guard and an upstream cap. The valve is actuated by deflecting a valve stem, located in the bore and accessible by the animal, to open a valve within the housing. The valve may be located in a valve cartridge retainable in the housing in a snap-fit manner. A bite-resistant shield cooperates with the valve stem to act as a barrier that prevents an animal from forcing materials between the valve stem and the guard and lodging the valve stem in its deflected or actuated position.

Abstract: An automatic animal watering system has a manifold for transporting drinking water, a controlled volume dispenser in the manifold for receiving a volume of drinking water, an inlet valve, and an outlet valve. A plurality of drinking valve assemblies is provided in fluid communication with the manifold between the inlet and outlet valves. A fluid sensor, capable of responding to changes in one or both of the water volume and pressure, is provided in the manifold between the inlet and outlet valves. The volume of drinking water available to the drinking valve assemblies can be regulated as a function of time to limit maximum potential leakage. The system also includes a controller receiving signals from the fluid sensor and generating a response to changes in the monitored water volume or pressure, thereby limiting potential water leakage in the system.

Abstract: An animal watering valve has an elastomeric diaphragm disposed in a bore of a housing upstream of a valve seat and having apertures formed therethrough for the passage of water. A valve stem has a head clamped between the diaphragm and the valve seat and a tail that is laterally deflectable to move the valve stem head relative to the diaphragm from a seated position. Upon moving it to an unseated position, the valve stem head pivots relative to the valve seat to permit water to flow out of the valve. At least portions of the flow aperture outlets in the diaphragm are located radially inwardly of and axially upstream of the upstream surface of the valve stem head.

Abstract: A method and apparatus is provided for regulating the flow of rates of particulate matter. The invention includes a flow gate with a generally cylindrical body having a flow path defined there through. A stator member is provided in fixed position relative to the cylindrical body. The stator member has a plurality of alternating tapered vein portions and inlet portions. A rotor member is interfaced with the stator member. The rotor member has a plurality of alternating stock portions and outlet port portions. The rotary coupling is utilized to couple the rotor member and the stator member. A position actuator is provided for receiving at least one control input and producing a corresponding displacement of the rotor member. A mechanical coupling is provided between the position actuator and the rotor member.

Abstract: A method and apparatus is provided for regulating the flow of rates of particulate matter. The invention includes a flow gate with a generally cylindrical body having a flow path defined there through. A stator member is provided in fixed position relative to the cylindrical body. The stator member has a plurality of alternating tapered vein portions and inlet portions. A rotor member is interfaced with the stator member. The rotor member has a plurality of alternating stock portions and outlet port portions. The rotary coupling is utilized to couple the rotor member and the stator member. A position actuator is provided for receiving at least one control input and producing a corresponding displacement of the rotor member. A mechanical coupling is provided between the position actuator and the rotor member.

Abstract: A method and apparatus is provided for regulating the flow of rates of particulate matter. The invention includes a flow gate with a generally cylindrical body having a flow path defined there through. A stator member is provided in fixed position relative to the cylindrical body. The stator member has a plurality of alternating tapered vein portions and inlet portions. A rotor member is interfaced with the stator member. The rotor member has a plurality of alternating stock portions and outlet port portions. The rotary coupling is utilized to couple the rotor member and the stator member. A position actuator is provided for receiving at least one control input and producing a corresponding displacement of the rotor member. A mechanical coupling is provided between the position actuator and the rotor member.

Abstract: A method and apparatus is provided for regulating the flow of rates of particulate matter. The invention includes a flow gate with a generally cylindrical body having a flow path defined there through. A stator member is provided in fixed position relative to the cylindrical body. The stator member has a plurality of alternating tapered vein portions and inlet portions. A rotor member is interfaced with the stator member. The rotor member has a plurality of alternating stock portions and outlet port portions. The rotary coupling is utilized to couple the rotor member and the stator member. A position actuator is provided for receiving at least one control input and producing a corresponding displacement of the rotor member. A mechanical coupling is provided between the position actuator and the rotor member.

Abstract: A method and apparatus is provided for regulating the flow of rates of particulate matter. The invention includes a flow gate with a generally cylindrical body having a flowpath defined there through. A stator member is provided in fixed position relative to the cylindrical body. The stator member has a plurality of alternating tapered vein portions and inlet portions. A rotor member is interfaced with the stator member. The rotor member has a plurality of alternating stock portions and outlet port portions. The rotary coupling is utilized to couple the rotor member and the stator member. A position actuator is provided for receiving at least one control input and producing a corresponding displacement of the rotor member. A mechanical coupling is provided between the position actuator and the rotor member.

Abstract: An assembly for permitting temperature measurements at a large number of locations within a vessel, which assembly has a spreader-reducer for compacting a significantly large number of thermocouple cables into a relatively small volume so as to permit passage through one or more vessel nozzles. The thermocouple cables each has a heat expansion portion as well as a seat, thereby permitting a series of horizontal arrays of thermocouple junctions positioned at different depths within the vessel.