Patents by Inventor Paul S. Miller

Paul S. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220343440
    Abstract: A system, method, and operating environment facilitate providing year-round agriculture management services to a grower. The method may include determining a geographic location of a field associated with a grower; obtaining information representative of an event prediction, such as a weather forecast, corresponding to the geographic location from one or more information sources; obtaining grower data associated with the grower; predicting an agronomic consequence based on the event prediction and the grower data; and providing a notification of the event prediction to the grower.
    Type: Application
    Filed: September 29, 2020
    Publication date: October 27, 2022
    Inventors: Greg Zimmers, Paul S. Miller, Richard Penhale
  • Publication number: 20220265346
    Abstract: A balloon for renal nerve modulation is disclosed. The balloon may include a polymer material forming a balloon wall having an outer surface and flexible circuits comprising a base selectively adhered to the exterior surface of the balloon wall. Adhesive is selectively applied to the outer surface of the balloon, to the flexible circuit or to both such that the adhesive is selectively deposited on the at least a portion of the at least two pads or on the at least a portion of the at least two pads and to a portion of the distal spline. The portion of the at least two pads or the portion of the at least two pads and a portion of the distal spline are adhered to the outer surface of the balloon and a remainder of the flexible circuit moves freely with respect to the outer surface of the balloon.
    Type: Application
    Filed: May 13, 2022
    Publication date: August 25, 2022
    Inventors: Ajay Gupta, Jeffrey S. Lindquist, Paul J. Miller, Cass A. Hanson, Daniel T. Quillin, Hong Cao, Kenneth R. Larson
  • Publication number: 20220051350
    Abstract: At least some aspects of the present disclosure are directed to systems and methods of an agronomic condition prediction and alerts engine. In some cases, the engine receives a set of field data and the set of field data includes one or more of geospatial data, crop data, user data, agronomic data, and weather data. In some cases, the engine retrieves a set of agronomic profile data from an agronomic data repository, where each of the set of agronomic profile data representing an agronomic condition and comprising one or more of geospatial profile, crop profile, pest profile, agronomic profile, user data profile, and weather profile corresponding to the agronomic condition. In some embodiments, the engine applies a multivariable processing to the set of field data using the set of agronomic profile data and generates an agronomic condition indicator indicative of one or more agronomic conditions.
    Type: Application
    Filed: August 12, 2020
    Publication date: February 17, 2022
    Inventors: Paul S. Miller, Brent Trenhaile
  • Patent number: 6005094
    Abstract: Acid resistant Oligomers suitable for oral administration, orally acceptable formulations of such Oligomers and preparation of pharmaceutical formations of such Oligomers are provided.
    Type: Grant
    Filed: December 27, 1994
    Date of Patent: December 21, 1999
    Assignees: Genta Incorporated, The Johns Hopkins University
    Inventors: Lionel N. Simon, Paul S. Miller, Paul O. P. Ts'o
  • Patent number: 5912339
    Abstract: A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional.
    Type: Grant
    Filed: November 16, 1994
    Date of Patent: June 15, 1999
    Assignee: The Johns Hopkins University
    Inventors: Paul S. Miller, Paul O.P. Ts'o
  • Patent number: 5665541
    Abstract: A specific segment of double stranded DNA may be detected or recognized by formation of a triple helix structure using an Oligomer comprising an 8-modified purine base such as 8-oxo-adenine or 8-oxo-guanine to form a detectable triple helix complex. Function or expression of double stranded DNA segments may be prevented by triple helix formation. Novel Oligomers comprising an 8-modified purine base are useful in triple helix formation, and may be optionally derivatized with DNA modifying groups.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: September 9, 1997
    Assignee: The Johns Hopkins University
    Inventors: Paul S. Miller, Purshotam Bhan
  • Patent number: 5627951
    Abstract: A graphic display for chroma keyer controls presents background hue as a radial spoke of an outer chroma vector circle, with selectivity being displayed as a wedge about the radial spoke. Foreground suppression may be added to the graphic display by providing a concentric inner chroma vector circle with the foreground suppression hue being a radial spoke of the inner circle and foreground selectivity being a wedge within the inner circle about such radial spoke. That portion of the outer circle that is overlapped by the inner circle is suppressed, or rendered invisible, so that the background chroma information appears as a torus about the inner chroma vector circle.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: May 6, 1997
    Assignee: Tektronix, Inc.
    Inventors: Daniel J. Chaplin, Paul M. Trethewey, Paul S. Miller
  • Patent number: 5407801
    Abstract: An oligonucleotide or analog thereof including a single cytidine residue at a selected position and having one or more cytidine residues which are 5-methyl substituted. The cytidine nucleus can be selectively transaminated to include an aminoalkyl or carboxyalkyl group as a linker for other functional groups which can be used to form DNA duplexes and triplexes.
    Type: Grant
    Filed: August 3, 1993
    Date of Patent: April 18, 1995
    Assignee: The Johns Hopkins University
    Inventor: Paul S. Miller
  • Patent number: 4757055
    Abstract: A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for said nucleic acid and binding the said nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: July 12, 1988
    Assignee: The Johns Hopkins University
    Inventors: Paul S. Miller, Paul O. P. Ts'O
  • Patent number: 4591614
    Abstract: Oligonucleoside-3'-alkyl or aryl phosphonates are prepared by condensing (i) a 5'-protected nucleoside 3'-alkyl or aryl phosphonic imidazolide with (ii) a nucleoside or oligomer which is attached through its 3'-position to a polymer support. The process is advantageously carried out in the presence of tetrazole.
    Type: Grant
    Filed: April 30, 1984
    Date of Patent: May 27, 1986
    Assignee: The Johns Hopkins University
    Inventors: Paul S. Miller, Paul O. P. T'so
  • Patent number: 4587044
    Abstract: A nucleic acid-protein conjugate which is specific with respect to a selected living cell is prepared by linking said nucleic acid to a protein specific to said living cell.
    Type: Grant
    Filed: September 1, 1983
    Date of Patent: May 6, 1986
    Assignee: The Johns Hopkins University
    Inventors: Paul S. Miller, Paul O. P. Ts'O
  • Patent number: 4511713
    Abstract: A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for the nucleic acid and binding the nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.
    Type: Grant
    Filed: March 29, 1982
    Date of Patent: April 16, 1985
    Assignee: The Johns Hopkins University
    Inventors: Paul S. Miller, Paul O. P. Ts'O
  • Patent number: 4507433
    Abstract: Process for synthesizing deoxyribonucleoside methylphosphonates on polystyrene polymer supports which involves condensing 5'-dimethoxytrityldeoxynucleoside 3'-methylphosphonates. The oligomers are removed from the support and the base protecting groups hydrolyzed by treatment with ethylenediamene in ethanol, which avoids hydrolysis of the methylphosphonate linkages. Two types of oligomers are synthesized: those containing only methylphosphonate linkages, d-Np(Np).sub.n N, and those which terminate with a 5' nucleotide residue, dNp(Np).sub.n N. The latter oligomers can be phosphorylated by polynucleotide kinase, and are separated by polyacrylamide gel electrophoresis according to their chain length. Piperidine randomly cleaves the oligomer methylphosphonate linkages and generates a series of shorter oligomers whose number corresponds to the length of the original oligomer. Apurinic sites introduced by acid treatment spontaneously hydrolyze to give oligomers which terminate with free 3' and 5'-OH groups.
    Type: Grant
    Filed: October 7, 1983
    Date of Patent: March 26, 1985
    Assignee: The Johns Hopkins University
    Inventors: Paul S. Miller, Paul O. P. Ts'O
  • Patent number: 4469863
    Abstract: Oligonucleoside alkyl-- or aryl phosphonates are nonionic analogues of nucleic acid which possess unique physical and biological properties. These properties enable the analogues to enter living cells intact and to bind with specifically selected nucleic acids within the cell. As a result, the analogues can specifically inhibit the function or expression of a preselected nucleic acid sequence. Thus the analogues could be used to specifically inhibit the growth of tumor cells or replication of viruses in infected cells.
    Type: Grant
    Filed: November 12, 1980
    Date of Patent: September 4, 1984
    Inventors: Paul O. P. Ts'o, Paul S. Miller
  • Patent number: 4413367
    Abstract: Portions of the confining frame of a water bed are made so they can be tilted away from the water-filled mattress of that water bed to facilitate the positioning, and the smoothing, of a cover for that water-filled mattress adjacent the sides and end of that water-filled mattress.
    Type: Grant
    Filed: June 16, 1982
    Date of Patent: November 8, 1983
    Assignee: Michael J. Rossi
    Inventors: Paul S. Miller, Michael J. Rossi