Abstract: Processes for preparing modified pigments are described. In one embodiment, the process comprises the step of combining, in any order, a pigment having attached an electrophilic group and a thiol reagent comprising at least one —SH group and at least two ionic or ionizable groups. In a second embodiment, the process comprises the step of combining, in any order, a pigment having attached an electrophilic group and a thiopolymer comprising at least one —H group. Modified pigments are also described.

Abstract: Processes for preparing modified pigments are described. In one embodiment, the process comprises the step of combining, in any order, a pigment having attached an electrophilic group and a thiol reagent comprising at least one —SH group and at least two ionic or ionizable groups. In a second embodiment, the process comprises the step of combining, in any order, a pigment having attached an electrophilic group and a thiopolymer comprising at least one —SH group. Modified pigments are also described.

Abstract: The present invention describes a dispersion comprising a vehicle and a modified pigment. The modified pigment has, when measured in an aqueous medium, a zeta potential of 0.0 mV at a pH of between 5.0 and 11.0. Inkjet ink compositions and an inkjet consumable set are also disclosed.

Abstract: A process for preparing a modified pigment having attached at least one organic group is described. This process comprises the step of reacting a dried mixture comprising a pigment having attached at least one reactive group and a modifying agent. The dried mixture is reacted under high intensity mixing conditions for a time and temperature sufficient to form the modified pigment.

Abstract: Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.

Abstract: The present invention describes a dispersion comprising a vehicle and a modified pigment. The modified pigment has, when measured in an aqueous medium, a zeta potential of 0.0 mV at a pH of between 5.0 and 11.0. Inkjet ink compositions and an inkjet consumable set are also disclosed.

Abstract: Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.

Abstract: Colored pigments having one or more desired parameters and/or properties are described. These parameters and/or properties include: a) a particles size of from about 10 nm to about 300 nm; b) an accusizer number of less than 1010 particles/ml of dispersion at 15% solids which are greater than 0.5 micron; c) a filterability such that when in a liquid medium, 100 ml having 10% solids of the colored pigment filters through a 3 micron nylon absolute filter; d) a colored pigment purity of greater than about 80%, based on extractable material; and/or e) a stability such that the above-described properties do not change by more than 50% at 25 degrees C. for at least one week. Colored pigments having at least one organic group and having one or more of the above-described characteristics is also described as well as a process for preparing surface-modified colored pigments.

Abstract: Methods of making a modified pigment by reacting a first chemical group and a second chemical group to form a pigment having attached a third chemical group. The first chemical group includes at least one nucleophile and the second chemical group includes at least one electrophile, or vice versa. Resulting modified pigments, and ink compositions containing such pigments, are also described.

Abstract: The present invention relates to cationic pigments having an organic group which comprises: a) at least one aromatic group, at least one C1-20 alkyl group, or both; and b) at least one cationically charged ionic group, at least one cationically chargeable ionizable group or both, and a corresponding counter-anion. The cationic pigments of the present invention have been found useful in aqueous or solvent based compositions and particularly in ink compositions, especially ink jet ink compositions. A method for preparing the cationic pigments is also disclosed.

Abstract: Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.

Abstract: Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.

Abstract: A compound represented by the formula ##STR1## wherein X is a spacer group. The compound is useful for conjugating a compound having an alcohol group or an amine group to a compound having a thiol group. The compound can be used to conjugate a biologically active group such as an antigen to a protein such as an enzyme to provide an enzyme-labeled antigen for use in enzyme-amplified immunoassay methods for analytes or metabolites in sample fluids. The compound can also be used to immobilize a material such as a protein to a solid support.

Abstract: Compounds which are useful as substrates for enzymes are disclosed. An enzyme-controlled process is provided for generating a colored species from an initially substantially colorless material as a result of enzymatic attack. The process can be exploited to provide an enzyme-amplified diagnostic assay method to detect an analyte of interest present in a test sample.

Abstract: This invention relates to an enzyme-controlled release method for the release of a leaving group comprising:contacting a compound represented by the formula ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 each independently is hydrogen, a substituent affecting the mobility or reactivity of the compound or a substituent including a biologically active group;X is leaving group;Z is an enzyme substrate moiety;--CR.sub.2 R.sub.3 X is either ortho or para to the --O--Z moiety;with an active capable of cleaving said enzyme substrate moiety Z from said compound;whereby said leaving group X is released from said compound.

Abstract: The present invention provides an enzyme controlled release system and prepared reactant by which an identifiable molecule may be released on demand through the action of an active enzyme. The controlled release system is useful for detection of an analyte of interest present in a test sample in picogram per liter quantities and may be employed in a variety of different modes of use including immunoassays, enzyme amplification systems and the release of pharmacologically active ligands.

Abstract: There are provided novel fluorescent conjugates comprising a rhodamine dye moiety and a biologically active moiety. In addition, there are provided methods for determining an analyte in a biological fluid.

Abstract: Fluorescent compounds which are conjugates of a biologically active moiety and an arylidene dye moiety. The compounds have a large Stokes shift and are useful in applications such as biological diagnostic elements.

Abstract: This invention relates to photographic processes and products for forming an image in dye from a colorless precursor of a preformed image dye which is substituted with a moiety containing a thiazolidinyl group, said thiazolidinyl group (a) being capable of undergoing cleavage imagewise in the presence of an imagewise distribution of silver ion and/or soluble silver complex and (b) possessing a substituent on the carbon atom in the 2-position which upon cleavage of said thiazolidinyl group, undergoes a .beta.-elimination reaction followed by an intramolecularly accelerated nucleophilic displacement reaction, which moiety maintains the precursor in its colorless form at least until said thiazolidinyl group undergoes said cleavage. In a further embodiment, this sequence of reactions is used to release an imagewise distribution of a photographically useful reagent which reagent may be, for example, a photographically active reagent.

Abstract: This invention relates to photographic processes and products for forming an image in dye from a colorless precursor of a preformed image dye which is substituted with a moiety containing a thiazolidinyl group, said thiazolidinyl group (a) being capable of undergoing cleavage imagewise in the presence of an imagewise distribution of silver ion and/or soluble silver complex and (b) possessing a substituent on the carbon atom in the 2-position which upon cleavage of said thiazolidinyl group, undergoes a .beta.-elimination reaction followed by an intramolecularly accelerated nucleophilic displacement reaction, which moiety maintains the precursor in its colorless form at least until said thiazolidinyl group undergoes said cleavage. In a further embodiment, this sequence of reactions is used to release an imagewise distribution of a photographically useful reagent which reagent may be, for example, a photographically active reagent.