Patents by Inventor Paul Saftig

Paul Saftig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of neuronal ceroid lipofuscinosis
    Patent number: 12053510
    Abstract: The invention provides for novel treatments of lysosomal storage diseases, in particular of Neuronal Ceroid Lipofuscinosis (NCL) or synucleinopathy or a disease characterized by block of autophagic flow. The treatment comprises administration of human pro-Cathepsin, in particular human pro-Cathpsin D, B or L to patients in need thereof.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: August 6, 2024
    Assignee: ORFONEURO APS
    Inventors: Jens Morten Fogh, Paul Saftig, Friederike Zunke, André Rosa Alcalde Marques
  • TREATMENT OF NEURONAL CEROID LIPOFUSCINOSIS
    Publication number: 20210169998
    Abstract: The invention provides for novel treatments of lysosomal storage diseases, in particular of Neuronal Ceroid Lipofuscinosis (NCL) or synucleinopathy or a disease characterized by block of autophagic flow. The treatment comprises administration of human pro-Cathepsin, in particular human pro-Cathpsin D, B or L to patients in need thereof.
    Type: Application
    Filed: May 1, 2019
    Publication date: June 10, 2021
    Inventors: Jens Morten FOGH, Paul SAFTIG, Friederike ZUNKE, André Rosa Alcalde MARQUES
  • Methods of Producing a Secreted Protein
    Publication number: 20170022506
    Abstract: The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization and/or sorting of the polypeptide in the cell. In general, the methods comprise culturing a lysosomal integral membrane protein II (LIMP-2) deficient cell which expresses the polypeptide or the variant thereof under conditions in which the polypeptide or the variant thereof is produced.
    Type: Application
    Filed: April 22, 2016
    Publication date: January 26, 2017
    Inventors: David J. Reczek, Paul Saftig, Christine T. DeMaria
  • Methods Of Producing A Secreted Protein
    Publication number: 20150246960
    Abstract: The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization and/or sorting of the polypeptide in the cell. In general, the methods comprise culturing a lysosomal integral membrane protein II (LIMP-2) deficient cell which expresses the polypeptide or the variant thereof under conditions in which the polypeptide or the variant thereof is produced.
    Type: Application
    Filed: January 9, 2015
    Publication date: September 3, 2015
    Inventors: David J. Reczek, Paul Saftig, Christine T. DeMaria
  • Methods of producing a secreted protein
    Patent number: 8962273
    Abstract: The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization and/or sorting of the polypeptide in the cell. In general, the methods comprise culturing a lysosomal integral membrane protein II (LIMP-2) deficient cell which expresses the polypeptide or the variant thereof under conditions in which the polypeptide or the variant thereof is produced.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: February 24, 2015
    Assignees: Genzyme Corporation, Biochemical Institute, Christian-Albrechts University Kiel
    Inventors: David J. Reczek, Paul Saftig, Christine T. DeMaria
  • Methods of Producing a Secreted Protein
    Publication number: 20100330617
    Abstract: The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization and/or sorting of the polypeptide in the cell. In general, the methods comprise culturing a lysosomal integral membrane protein II (LIMP-2) deficient cell which expresses the polypeptide or the variant thereof under conditions in which the polypeptide or the variant thereof is produced.
    Type: Application
    Filed: May 9, 2008
    Publication date: December 30, 2010
    Inventors: David J. Reczek, Paul Saftig, Christine T. DeMaria