Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: Systems and methods are provided for configuration of a secondary processor by a host processor. The host processor can access compiled firmware for the secondary processor, which has a parameter stored at a pre-determined address. The host processor can modify the parameter at the pre-determined address in the firmware to generate a modified firmware for the secondary processor. The host processor can further load the modified firmware into a memory of the secondary processor. The secondary processor can execute the modified firmware having the modified parameter. The host processor can further remodify the parameter in the memory of the secondary processor during runtime without having to recompile the firmware.

Abstract: A gasket assembly and methods of construction and assembly thereof are provided. The gasket assembly includes an elastically deformable, resilient carrier layer having an upper surface and a lower surface extending in planar, generally parallel relation with one another between an inner periphery and an outer periphery when in a disassembled state. At least one top layer is fixed to the upper surface proximate at least one of the inner periphery and the outer periphery. At least one bottom layer is fixed to the lower surface in radially spaced relation from the at least one top layer. The upper surface and the lower surface take on a non-planar, spring-biased shape upon compressing the gasket assembly between a pair of surfaces to an assembled state.

Abstract: A glove, including an 18 gauge knitted liner, a foamed nitrile coating disposed on at least a portion of the knitted liner; and a plurality of cavities disposed on a surface and throughout the foamed nitrile coating, wherein the glove exhibits an EN level 4 abrasion resistance and methods of making the glove are disclosed.

Abstract: An article having a textured surface and a method for manufacturing such an article is provided. The article comprises a polymeric layer coated on at least a portion of the article, a plurality of cavities formed in the polymeric layer, wherein each cavity in the plurality of cavities have a size between about 50 microns to about 2000 microns, and wherein a majority of the plurality of cavities have encircling perimeter ridges, and a plurality of channels formed in the polymeric layer between the encircling perimeter ridges.

Abstract: An article having a textured surface and a method for manufacturing such an article is provided. The article comprises a polymeric layer coated on at least a portion of the article, a plurality of cavities formed in the polymeric layer, wherein each cavity in the plurality of cavities have a size between about 50 microns to about 2000 microns, and wherein a majority of the plurality of cavities have encircling perimeter ridges, and a plurality of channels formed in the polymeric layer between the encircling perimeter ridges.

Abstract: A glove, including an 18 gauge knitted liner, a foamed nitrile coating disposed on at least a portion of the knitted liner; and a plurality of cavities disposed on a surface and throughout the foamed nitrile coating, wherein the glove exhibits an EN level 4 abrasion resistance and methods of making the glove are disclosed.

Abstract: A compact chromatographic device and use thereof are disclosed. The device permits trapping of a first analyte while permitting passage of other analytes, followed by trapping of a second and subsequent analytes in an orderly series. Each analyte is trapped sequentially by a different chromatographic media. The process allows detection and/or measurement of each analyte without interference from other analytes previously trapped, enabling assays of analytes in a compact device without elution of analytes from the device. The compact device is pre-assembled and ready to use in a point of care or non-laboratory setting.

Abstract: A testing cartridge for metering of a sample to be tested. The testing cartridge includes a casing defining a casing opening and a sliding member defining a sliding member opening. The casing opening or the sliding member opening can define a specified volume, wherein the casing opening and the sliding member opening collectively define a sample application region dimensioned to accommodate receiving an amount of sample exceeding the specified volume. The sliding member is movable transversely to the casing opening by having the sliding member and the casing traverse across each other's respective openings to remove excess sample from the received amount of sample and retain the specified volume from the received amount of sample.

Abstract: A cut resistant chemical handling glove that is flexible and lightweight comprises a cured, liquid-impervious polymeric latex shell. A tacky acrylic adhesive with low shear strength can be used. A cut resistant liner is slipped on the tacky adhesive coating and is infiltrated with a polymeric latex coating and cured to integrally attach the cut resistant liner with the cured polymeric coating. When the latex glove is worn on a hand and a cutting edge, such as a knife edge, contacts the glove, a crease is formed due to slip at the tacky adhesive-cut resistant liner interface creating a geometry that reduces cut stress intensity at the knife-edge thereby increasing the cut resistance of the glove. Processes for making and using these gloves are also described.

Abstract: A testing cartridge for metering of a sample to be tested. The testing cartridge includes a casing defining a casing opening and a sliding member defining a sliding member opening. The casing opening or the sliding member opening can define a specified volume, wherein the casing opening and the sliding member opening collectively define a sample application region dimensioned to accommodate receiving an amount of sample exceeding the specified volume. The sliding member is movable transversely to the casing opening by having the sliding member and the casing traverse across each other's respective openings to remove excess sample from the received amount of sample and retain the specified volume from the received amount of sample.

Abstract: A carbon nanofoam composite (such as carbon nanofoam paper) includes a carbon foam of interconnected pores of ˜10-2000 nm in size with nanometric carbon walls having a thickness on the order of 20 nm. In embodiments, the carbon nanofoam composite has electronic conductivity of greater than 20 S/cm and optionally at least ˜100 S/cm.

Abstract: An article comprising at least one cured, liquid-impervious polymeric shell substantially free from defects, at least one liner, and a non-tacky, thermoplastic adhesive layer between the shell and the liner, wherein the adhesive layer is melted and solidified to create a non-tacky bond between the shell and the liner, which can be moisture-absorbing or cut-resistant, whereby the liner supports and limits stretch ability of the shell, thereby preventing adhesive delamination between the adhesive layer and either of the shell and/or the liner; a method for the manufacture of an article comprising a supported, polymeric shell, such as a glove, a gauntlet, an apron, or a boot, comprising providing a cured, liquid-impervious, polymeric shell, providing a knitted/woven liner, incorporating a non-tacky, thermoplastic adhesive layer between the shell and the liner, such as by hot-melt spraying, dry-powder spraying or fiber-coating, creating intimate contact between the shell, the adhesive layer, and the liner, subjec

Abstract: Methods and kits for performing a two-phase optical assay for one or more than one analyte without intrinsic optical contrast in a sample are disclosed. The method requires use of a functionalized microparticle immobilized with two or more than functional components and an additional set of one or more than one functional component. The assay can be performed in one single container and does not need a wash step.

Abstract: An article comprising at least one cured, liquid-impervious polymeric shell substantially free from defects, at least one liner, and a non-tacky, thermoplastic adhesive layer between the shell and the liner, wherein the adhesive layer is melted and solidified to create a non-tacky bond between the shell and the liner, which can be moisture-absorbing or cut-resistant, whereby the liner supports and limits stretch ability of the shell, thereby preventing adhesive delamination between the adhesive layer and either of the shell and/or the liner; a method for the manufacture of an article comprising a supported, polymeric shell, such as a glove, a gauntlet, an apron, or a boot, comprising providing a cured, liquid-impervious, polymeric shell, providing a knitted/woven liner, incorporating a non-tacky, thermoplastic adhesive layer between the shell and the liner, such as by hot-melt spraying, dry-powder spraying or fiber-coating, creating intimate contact between the shell, the adhesive layer, and the liner, subjec

Abstract: A damage tolerant cut resistant chemical handling glove that is flexible and lightweight comprises a cured, liquid-impervious polymeric latex shell, a knitted cut resistant liner comprising a cotton yarn and at least one cut resistant yarn, the liner being infiltrated with a soft nitrile or polyurethane layer such that the liner bonds to the shell. The soft nitrile or polyurethane layer seals interstices of the cut resistant liner and replicates its rough texture on the external surface of the glove, providing enhanced grip properties. A thin nitrile latex layer applied to and cured together with the polyurethane layer to protect the polyurethane layer from oil or chemical degradation. The intimate seal thus created between the shell and the liner prevents accumulation of liquid there between, which prevents formation of a liquid boundary layer and interference with grip properties of the glove.

Abstract: An article comprising at least one cured, liquid-impervious polymeric shell substantially free from defects, at least one liner, and a non-tacky, thermoplastic adhesive layer between the shell and the liner, wherein the adhesive layer is melted and solidified to create a non-tacky bond between the shell and the liner, which can be moisture-absorbing or cut-resistant, whereby the liner supports and limits stretch ability of the shell, thereby preventing adhesive delamination between the adhesive layer and either of the shell and/or the liner; a method for the manufacture of an article comprising a supported, polymeric shell, such as a glove, a gauntlet, an apron, or a boot, comprising providing a cured, liquid-impervious, polymeric shell, providing a knitted/woven liner, incorporating a non-tacky, thermoplastic adhesive layer between the shell and the liner, such as by hot-melt spraying, dry-powder spraying or fiber-coating, creating intimate contact between the shell, the adhesive layer, and the liner, subjec

Abstract: An article comprising at least one cured, liquid-impervious polymeric shell substantially free from defects, at least one liner, and a non-tacky, thermoplastic adhesive layer between the shell and the liner, wherein the adhesive layer is melted and solidified to create a non-tacky bond between the shell and the liner, which can be moisture-absorbing or cut-resistant, whereby the liner supports and limits stretch ability of the shell, thereby preventing adhesive delamination between the adhesive layer and either of the shell and/or the liner; a method for the manufacture of an article comprising a supported, polymeric shell, such as a glove, a gauntlet, an apron, or a boot, comprising providing a cured, liquid-impervious, polymeric shell, providing a knitted/woven liner, incorporating a non-tacky, thermoplastic adhesive layer between the shell and the liner, such as by hot-melt spraying, dry-powder spraying or fiber-coating, creating intimate contact between the shell, the adhesive layer, and the liner, subjec

Abstract: An article comprising at least one cured, liquid-impervious polymeric shell substantially free from defects, at least one liner, and a non-tacky, thermoplastic adhesive layer between the shell and the liner, wherein the adhesive layer is melted and solidified to create a non-tacky bond between the shell and the liner, which can be moisture-absorbing or cut-resistant, whereby the liner supports and limits stretch ability of the shell, thereby preventing adhesive delamination between the adhesive layer and either of the shell and/or the liner; a method for the manufacture of an article comprising a supported, polymeric shell, such as a glove, a gauntlet, an apron, or a boot, comprising providing a cured, liquid-impervious, polymeric shell, providing a knitted/woven liner, incorporating a non-tacky, thermoplastic adhesive layer between the shell and the liner, such as by hot-melt spraying, dry-powder spraying or fiber-coating, creating intimate contact between the shell, the adhesive layer, and the liner, subjec