Abstract: This invention relates to compounds that can be used to treat viral infections. The compounds are papain-like protease (PLpro) inhibitors.

Abstract: A waste disposal device for sealing waste and a cassette for dispensing film are disclosed. The waste disposal device comprises first and second rollers, each comprising first and second end portions and a joining portion therebetween. The end portions of the first and second rollers are arranged to receive and seal first and second film portions therebetween as the first and second rollers rotate. The joining portions of the first and second rollers are arranged to define an aperture for receiving waste in a first rotary configuration of the rollers and to seal the first and second film portions therebetween in a second rotary configuration of the first and second rollers. The cassette comprises first and second portions comprising respective first and second film dispensers. The first portion is mechanically connected to the second portion. The cassette is moveable between a first, compact configuration and a second, extended configuration.

Abstract: Disclosed herein is a valve assembly for a feeding or drinking vessel. The valve assembly comprises a valve seat surface (229), and a valve element having a valve face opposing said valve seat surface (229), a center axis and a rim (232). The valve element further comprises a biasing element (242) configured such that, in a rest position, the valve face is biased against the valve seat surface (229), wherein the valve element rim (232) is arranged to be anchored and the biasing element (242) is arranged intermediate the valve element center axis and rim (232).

Abstract: A waste storage device is provided comprising a waste storage compartment for storing waste and a lid. The device further comprises a dispenser for dispensing an agent inside the waste storage device and an actuator arranged to activate the dispenser. A waste cartridge is also provided comprising a relatively rigid upper portion and a relatively flexible lower portion. The relatively flexible lower portion is arranged for storing waste items and the relatively rigid upper portion is arranged to be folded about an axis in a direction substantially towards the relatively flexible lower portion of the waste cartridge.

Abstract: Disclosed herein is a valve assembly for a feeding or drinking vessel. The valve assembly comprises a valve seat surface (229), and a valve element having a valve face opposing said valve seat surface (229), a center axis and a rim (232). The valve element further comprises a biasing element (242) configured such that, in a rest position, the valve face is biased against the valve seat surface (229), wherein the valve element rim (232) is arranged to be anchored and the biasing element (242) is arranged intermediate the valve element center axis and rim (232).

Abstract: A waste storage device is provided comprising a waste storage compartment for storing waste and a lid. The device further comprises a dispenser for dispensing an agent inside the waste storage device and an actuator arranged to activate the dispenser. A waste cartridge is also provided comprising a relatively rigid upper portion and a relatively flexible lower portion. The relatively flexible lower portion is arranged for storing waste items and the relatively rigid upper portion is arranged to be folded about an axis in a direction substantially towards the relatively flexible lower portion of the waste cartridge.

Abstract: A method of coating a honeycomb monolith substrate comprising a plurality of channels with a liquid comprising a catalyst component comprises the steps of: (i) holding a honeycomb monolith substrate substantially vertically; (ii) introducing a pre-determined volume of the liquid into the substrate via open ends of the channels at a lower end of the substrate; (iii) sealingly retaining the introduced liquid within the substrate; (iv) inverting the substrate containing the retained liquid; and (v) applying a vacuum to open ends of the channels of the substrate at the inverted, lower end of the substrate to draw the liquid along the channels of the substrate.

Abstract: A waste storage device is provided comprising a waste storage compartment for storing waste and a lid. The device further comprises a dispenser for dispensing an agent inside the waste storage device and an actuator arranged to activate the dispenser.

Abstract: A method of coating a honeycomb monolith substrate comprising a plurality of channels with a liquid comprising a catalyst component comprises the steps of: (i) holding a honeycomb monolith substrate substantially vertically; (ii) introducing a pre-determined volume of the liquid into the substrate via open ends of the channels at a lower end of the substrate; (iii) sealingly retaining the introduced liquid within the substrate; (iv) inverting the substrate containing the retained liquid; and (v) applying a vacuum to open ends of the channels of the substrate at the inverted, lower end of the substrate to draw the liquid along the channels of the substrate.

Abstract: A soother comprising a teat and a shield is constructed by co-molding the teat and the shield and over-molding the teat material on the shield material. As a result a secure bond is formed and a simple and easily cleanable soother is provided.

Abstract: A waste disposal device for sealing waste and a cassette for dispensing film are disclosed. The waste disposal device comprises first and second rollers, each comprising first and second end portions and a joining portion therebetween. The end portions of the first and second rollers are arranged to receive and seal first and second film portions therebetween as the first and second rollers rotate. The joining portions of the first and second rollers are arranged to define an aperture for receiving waste in a first rotary configuration of the rollers and to seal the first and second film portions therebetween in a second rotary configuration of the first and second rollers. The cassette comprises first and second portions comprising respective first and second film dispensers. The first portion is mechanically connected to the second portion. The cassette is moveable between a first, compact configuration and a second, extended configuration.

Abstract: A waste storage device (200) is provided comprising a waste storage compartment for storing waste and a lid (206). The device (200) further comprises a dispenser (208) for dispensing an agent inside the waste storage device (200) and an actuator (212) arranged to activate the dispenser (208).

Abstract: A method of coating a honeycomb monolith substrate comprising a plurality of channels with a liquid comprising a catalyst component comprises the steps of: (i) holding a honeycomb monolith substrate substantially vertically; (ii) introducing a pre-determined volume of the liquid into the substrate via open ends of the channels at a lower end of the substrate; (iii) sealingly retaining the introduced liquid within the substrate; (iv) inverting the substrate containing the retained liquid; and (v) applying a vacuum to open ends of the channels of the substrate at the inverted, lower end of the substrate to draw the liquid along the channels of the substrate.

Abstract: A method of coating a honeycomb monolith substrate comprising a plurality of channels with a liquid comprising a catalyst component comprises the steps of: (i) holding a honeycomb monolith substrate substantially vertically; (ii) introducing a pre-determined volume of the liquid into the substrate via open ends of the channels at a lower end of the substrate; (iii) sealingly retaining the introduced liquid within the substrate; (iv) inverting the substrate containing the retained liquid; and (v) applying a vacuum to open ends of the channels of the substrate at the inverted, lower end of the substrate to draw the liquid along the channels of the substrate.

Abstract: A method of coating a honeycomb monolith substrate comprising a plurality of channels with a liquid comprising a catalyst component comprises the steps of: (i) holding a honeycomb monolith substrate substantially vertically; (ii) introducing a pre-determined volume of the liquid into the substrate via open ends of the channels at a lower end of the substrate; (iii) sealingly retaining the introduced liquid within the substrate; (iv) inverting the substrate containing the retained liquid; and (v) applying a vacuum to open ends of the channels of the substrate at the inverted, lower end of the substrate to draw the liquid along the channels of the substrate.