Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: An adaptive centrifugal brake assembly is disclosed. The adaptive centrifugal brake assembly controls rotational speed of a shaft. The brake assembly is adaptive and changes braking force based at least in part on torque applied to the shaft and/or the speed of rotation of the shaft. In some embodiments, the adaptive centrifugal brake assembly includes an adaptive mechanism such as a leaf spring that enables the assembly to be adaptive.

Abstract: An escape system for descending a person from a window is disclosed. The escape system may be mounted above a window through which a person may egress and descend to the ground. The escape system includes a fenestration unit having a frame and a human support embedded into the frame in a stowed position. The human support carries a person during descent. A cable is wound about a shaft supported by the frame. The cable is connected to the human support. The escape system further includes a speed limiting device connected to the shaft that controls the speed of descent.

Abstract: An adaptive centrifugal brake assembly is disclosed. The adaptive centrifugal brake assembly controls rotational speed of a shaft. The brake assembly is adaptive and changes braking force based at least in part on torque applied to the shaft and/or the speed of rotation of the shaft. In some embodiments, the adaptive centrifugal brake assembly includes an adaptive mechanism such as a leaf spring that enables the assembly to be adaptive.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for operating a fenestration assembly having a vent panel. The apparatuses, systems, and methods may include an actuator having an engagement section configured to contact a horizontal portion of the fenestration assembly and a drive assembly configured to actuate the engagement section.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for operating a fenestration assembly having a vent panel. The apparatuses, systems, and methods may include an actuator having an engagement section configured to contact a horizontal portion of the fenestration assembly and a drive assembly configured to actuate the engagement section.

Abstract: In order to form a contact in a layer on a substrate, in particular a contact in a logic circuit in a semiconductor component, the mask layer is structured for etching of the contact holes with a photoresist layer which is exposed using two masks, with the first mask containing a regular pattern of contact structures with a period which corresponds to the order of magnitude of twice the edge length of the contact hole, and with the second mask containing a pattern with a structure which surrounds at least the contact hole area, and thus covers it.

Abstract: The invention relates to a method and an apparatus for the arrangement of contact-making elements of components of an integrated circuit, a computer-readable storage medium and a program element. In the method for the arrangement of contact-making elements of components of an integrated circuit, at least one part of at least one component having a larger extent along a first course direction than along a second course direction, which is orthogonal to the first course direction, and at least one contact-making element assigned to a component having, in cross section, a larger extent along a third course direction than along a fourth course direction, which is orthogonal to the third course direction, the contact-making element is arranged with respect to the assigned component in such a way that the first course direction of the component essentially runs parallel to the third course direction of the contact-making element.

Abstract: A tensioning system for drawing together abutting first and second portions of a closure assembly includes a base member and at least a first deformable member. The base member is attached to the first portion of the closure assembly. The first deformable member has a center portion, a proximal end mechanically coupled to the base member and a distal end attached to the second portion of the closure assembly. Deformation of the center portion generates a first tensioning force on the base member that draws the first portion of the closure assembly toward the second portion.

Abstract: An actuation system for use with an adjustable covering for a fenestration product. The actuation system coupled to an operator for controlling adjustment of extension and contraction of the covering. The actuation system including at least one lift mechanism configured to decouple the actuation system from the operator during a potentially damaging event, such as slack in a lift cord during extension of the covering. The lift mechanism later recoupling the actuation system and operator while maintaining rotational registration between multiple lift mechanisms of the actuation system.

Abstract: The invention relates to a method and an apparatus for the arrangement of contact-making elements of components of an integrated circuit, a computer-readable storage medium and a program element. In the method for the arrangement of contact-making elements of components of an integrated circuit, at least one part of at least one component having a larger extent along a first course direction than along a second course direction, which is orthogonal to the first course direction, and at least one contact-making element assigned to a component having, in cross section, a larger extent along a third course direction than along a fourth course direction, which is orthogonal to the third course direction, the contact-making element is arranged with respect to the assigned component in such a way that the first course direction of the component essentially runs parallel to the third course direction of the contact-making element.

Abstract: A mark configuration is provided for the orientation and/or determination of the relative position of a substrate and/or of layers on the substrate during a lithographic exposure, in particular for the case of a wafer during the fabrication of DRAMs. At least one part of a mark is disposed above a patterned background for the purpose of increasing a difference in contrast between the mark and the substrate. A wafer can also be manufactured with such a mark configuration. A method for fabricating the mark configuration is also described. An efficient and simple orientation of layers and/or of the substrate is thus made possible.

Abstract: A mark configuration is provided for the orientation and/or determination of the relative position of a substrate and/or of layers on the substrate during a lithographic exposure, in particular for the case of a wafer during the fabrication of DRAMs. At least one part of a mark is disposed above a patterned background for the purpose of increasing a difference in contrast between the mark and the substrate. A wafer can also be manufactured with such a mark configuration. A method for fabricating the mark configuration is also described. An efficient and simple orientation of layers and/or of the substrate is thus made possible.

Abstract: Apparatus for continuous flow weighing of a flowable material includes a pair of sequential conveyors. A first, control conveyor moves material from an inlet to a discharge point. A second, weighing conveyor is mounted for pivotal movement about a horizontal axis at its inlet end. The pivot point is positioned below the discharge of the control conveyor. The outlet end of the weighing conveyor is suspended from and weighed by a load cell. Electronic control circuitry monitors the material transport rate of the weighing conveyor which, in combination with the output of the loadcell, is used to determine the weight flow rate of material being discharged from the weighing conveyor. The material transport rate of the weighing auger is adjusted to result in a preselected weight flow rate.

Abstract: A tunnel kiln particularly adapted for firing ceramic workpieces has a firing channel including a heating zone, a firing zone, and a cooling zone, and has kiln cars and kiln sole sections which bear the workpieces to be treated and are movable through said firing channel. The kiln sole sections are separated from the kiln cars, and the kiln cars are constructed and arranged to be movable independently of the kiln sole sections.

Abstract: A gas-cooled a.c. machine having a rotor and a stator, each in the form of sheet metal packs, and a winding head, wherein in order to obtain optimum cooling of the rotor sheet metal pack, the stator sheet metal pack and the winding head, the machine is constructed of a stator central part and two stator end parts and ducts are provided in the casing corners for the removal of the cooling gas. The ducts are bounded only by the walls of the casing and the back of the stator sheet metal pack, are separated by the stator sheet metal pack, and extend over the total length thereof. Cooling gas conveyed by fans is first conveyed into the inner winding head chamber or the rotor inlet flow chamber and there divided into two cooling circuits connected in parallel. In a first cooling circuit, the cooling gas is led through the rotor sheet metal pack and through the stator sheet metal pack, and in the second cooling circuit through the winding head.

Abstract: Exchangeable elastic elements having an adaptable spring property which are installed in recesses provided in at least fastening part of a casing member for compensation in critical speed operation of vertical groups of machines. Compensation for critical speed operation of a mounted machine is possible by exchanging elastic elements or by changing the number of elastic elements utilized. The exchangeable elastic elements may include at least one borehole formed therewithin and within which a fastening element is disposed. The exchangeable elastic elements may be composed of different materials or have different spring properties and may also be designed as slide-in parts for insertion within the recesses provided in the at least one fastening part of the casing.