Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.

Abstract: The present invention comprises an apparatus and method for producing a microparticle and pharmaceutical compositions thereof. The apparatus and method rely on continuous inkjet (CIJ) printing to provide high quality microparticles at an improved rate.

Abstract: A nozzle mount for a swather includes a mounting plate configured for attachment to the swather, a nozzle head extending from one side of the mounting plate, and a nozzle shield attached to the mounting plate and configured to at least partially enclose the nozzle head to protect the nozzle head from impact damage while allowing the nozzle head to direct preconditioner fluid flow into the swather. The nozzle head is configured for attachment to a fluid source, such as a hay preservative, that can be sourced from a locally mounted tank.

Abstract: A controlled release pharmaceutical formulation is provided, comprising cyclosporine-loaded microparticles of a bioresorbable polymer comprising poly(D,L-lactide), wherein the mean diameter of the microparticles is in the range 20 ?m to 40 ?m. Also provided are medical uses of the pharmaceutical formulation, in particular in the treatment of uveitis, a process for production of the pharmaceutical formulation and injectable dosage forms, including those formulated for intravitreal injection.

Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.

Abstract: The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nanoparticles in medicine.

Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.

Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid.

Abstract: A controlled release pharmaceutical formulation is provided, comprising cyclosporine-loaded microparticles of a bioresorbable polymer comprising poly(D,L-lactide), wherein the mean diameter of the microparticles is in the range 20 ?m to 40 ?m. Also provided are medical uses of the pharmaceutical formulation, in particular in the treatment of uveitis, a process for production of the pharmaceutical formulation and injectable dosage forms, including those formulated for intravitreal injection.

Abstract: The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nano particles in medicine.

Abstract: A method of preparing milled solid particles of a compound comprises the steps of forming a slurry of a liquid medium, the compound and rigid milling media in a milling chamber, contacting the compound with the milling media while in the chamber to reduce the particle size of the compound, and thereafter separating the compound from the milling media by vacuum filtration through a removable filter probe immersed in the slurry. In a preferred embodiment, the milling media is a polymeric resin having a mean particle size of less than 300 .mu.m. The method enables the use of fine milling media which provides extremely fine particles of the compound while avoiding problems, e.g., decrease yields due to separator screen plugging, associated with prior art processes.