Abstract: Embodiments of the disclosure include methods and compositions for producing T cell receptor (TCR) polypeptides specific for hematological neoantigens. In specific embodiments. T cells directed to one or more hematological neoantigens are produced following exposure of PBMCs to peptides that encompass one or more neoantigens, and the TCRs in the produced T cells are tested for efficacy and identified. The neoantigen-specific TCRs are utilized in a variety of immunotherapies.

Abstract: A saw can include a guide for guiding a saw blade. In one embodiment, the guide can be moveable between an active position wherein the guide guides a saw blade and an inactive position wherein the guide does not guide the saw blade. In one embodiment, the guide in the active position limits lateral movement of the blade, and the guide defines a clearance between the guide and the blade, the clearance having a height greater than a height of the blade, the saw being configured so that during cutting at least a portion of the article being cut can be accommodated within the clearance without contacting the guide.

Abstract: A saw can include a guide for guiding a saw blade. In one embodiment, the guide can be moveable between an active position wherein the guide guides a saw blade and an inactive position wherein the guide does not guide the saw blade.