Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A cytotoxicity method for medical devices that has equivalent sensitivity, and greater efficiency compared to the colony formation assay (CFA) direct contact method is developed. The quantitative, direct contact cytotoxicity test method uses Mouse lymphoma TK or human lymphoblastoid TK6 suspension cells for medical device safety assessment. The advantages of using the suspension cell assay over adherent V79-4 cells is that this approach is quantitative, automated, not susceptible to potential mechanical damage imparted by the overlying test materials, and avoids issues related to non-adherence of cells to the test material which might impact the interpretation of test results.

Abstract: A new two-layer modified agar overlay cytotoxicity method for medical device safety assessment are developed. The new two layer modified agar overlay cytotoxicity method has equivalent sensitivity, and greater efficiency compared to the ISO/USP direct contact and agar overlay assays. Assays were carried out in 6-well microplates. Nutrient agar medium with a 0.5% agar concentration was used to provide a base nutrient layer to support cell growth, L929 cells mixed nutrient agar (0.33% agar) were seeded on top of the base agar and cytotoxicity was evaluated after 24 hours per USP. Results demonstrated the two layer modified agar overlay cytotoxicity assay performs as well as the ISO/USP direct contact method with distinct advantages.

Abstract: A connector assembly is provided that includes a carrier embedded within a molded frame. The carrier further includes an aperture positioned within an opening formed in the carrier configured to receive a boss formed on a connector housing. A connector module having a plurality of electrical terminals retained in the housing and secured to the frame. The connector module aligned to the frame by the carrier by the boss formed in the housing engaging the aperture. The carrier adding rigidity to the frame and providing a precise alignment of the connector modules to the frame.

Abstract: A cytotoxicity method for medical devices that has equivalent sensitivity, and greater efficiency compared to the colony formation assay (CFA) direct contact method is developed. The quantitative, direct contact cytotoxicity test method uses Mouse lymphoma TK or human lymphoblastoid TK6 suspension cells for medical device safety assessment. The advantages of using the suspension cell assay over adherent V79-4 cells is that this approach is quantitative, automated, not susceptible to potential mechanical damage imparted by the overlying test materials, and avoids issues related to non-adherence of cells to the test material which might impact the interpretation of test results.

Abstract: A connector assembly is provided that includes a carrier embedded within a molded frame. The carrier further includes an aperture positioned within an opening formed in the carrier configured to receive a boss formed on a connector housing. A connector module having a plurality of electrical terminals retained in the housing and secured to the frame. The connector module aligned to the frame by the carrier by the boss formed in the housing engaging the aperture. The carrier adding rigidity to the frame and providing a precise alignment of the connector modules to the frame.

Abstract: A back-wiring board that connects to a main circuit board of a power distribution system. The back-wiring board includes a plurality of connectors configured to mechanically secure to a plurality of bus bars. The connectors of the back-wiring board are further configured to receive a voltage signal from the plurality of bus bars and to transmit the voltage signal to the back-wiring board. The back-wiring board also includes a plurality of wire-wrap pins integrated into a surface of the back-wiring board, wherein the wire-wrap pins are configured to receive data input signals. The back-wiring board includes a right-angle connector configured to couple the back-wiring board to the main circuit board.

Abstract: A back-wiring board that connects to a main circuit board of a power distribution system. The back-wiring board includes a plurality of connectors configured to mechanically secure to a plurality of bus bars. The connectors of the back-wiring board are further configured to receive a voltage signal from the plurality of bus bars and to transmit the voltage signal to the back-wiring board. The back-wiring board also includes a plurality of wire-wrap pins integrated into a surface of the back-wiring board, wherein the wire-wrap pins are configured to receive data input signals. The back-wiring board includes a right-angle connector configured to couple the back-wiring board to the main circuit board.

Abstract: A hygienic door operating device comprising a dispensing means arranged to contain a plurality of gripping handles and adapted to dispense a separate handle to each person operating the door, the gripping handle being adapted to engage a formation secured to the door whereby the door can be operated by manual engagement of the gripping handle and disposal means to transfer the gripping handle to a collection receptacle after use

Abstract: The present invention relates to methods for detecting microbes in a sample comprising filtering the sample through a fluid-permeable surface, contacting the surface with a viability stain, scanning the surface for viability stain to form a first scan, contacting the surface with a nucleic acid stain, scanning the surface for nucleic acid stain to form a second scan, and comparing said first scan and said second scan.

Abstract: A fastening device is disclosed for attachment to a pole without the need for tools and without the need for excessive force to mount or remove the device from the pole. The device has an interior channel that is open along a side of the fastening device. The opening in the channel along the side of the device is defined by first edges that are uniformly spaced apart and contiguous second edges that are angled away from each other, starting with the spacing of the first edges, until their spacing is equal to the diameter of the pole. To mount the fastening device to the pole its top edge with the widest spacing of the second edges are placed against the pole and pushed on to the pole for a short distance before rotating the bottom of the fastening device on to the pole. This attachment sequence distributes the mounting force timewise making it easier to attach or remove the fastening device to or from the pole.

Abstract: A fastening device is disclosed which consists of a first portion that may be made as an integral part of an object such as small electronic devices, tools or cup holders and other items, or may be separately fastened thereto; and a second portion that may be made as an integral part of some apparel of a user, a supporting structure such as a wall, dash board of a vehicle, a pole, or other surface, or it may fastened thereto. The first portion has a generally keyhole shaped slot having a narrow slot with parallel sides, a flared entrance at one end of the slot, an enlarged hole at the other end of the narrow slot and channel behind the slot and hole. The second portion has a mushroom shape with a stem and a flat, button shaped top. The stem is attached perpendicularly to one side of the top, has a generally circular cross section and has one flat side along the length of the stem.

Abstract: A fastening device is disclosed for attachment to a pole without the need for tools and without the need for excessive force to mount or remove the device from the pole. The device has an interior channel that is open along a side of the fastening device. The opening in the channel along the side of the device is defined by first edges that are uniformly spaced apart and contiguous second edges that are angled away from each other, starting with the spacing of the first edges, until their spacing is equal to the diameter of the pole. To mount the fastening device to the pole its top edge with the widest spacing of the second edges are placed against the pole and pushed on to the pole for a short distance before rotating the bottom of the fastening device on to the pole. This attachment sequence distributes the mounting force timewise making it easier to attach or remove the fastening device to or from the pole.

Abstract: An impact sensor comprising a non-ferrous housing having a passage therein and an end member provided at each end of the housing for enclosing the passage at opposite end thereof. At least one pair of magnetic members is mounted in spaced relation in the passage with the first of the at least one pair of magnetic members being rigidly secured in the housing. The second of the at least one pair of magnetic members is slidably positioned in the passage. Each member of the at least one pair of magnetic members has opposite magnetic poles and are positioned in the passage with a pair of poles of like polarity facing each other and with only the repelling magnetic force between the poles of like polarity serving to maintain the spaced relation between the magnetic members of the at least one pair of magnetic members. An inductance coil is circumferentially mounted about the housing.

Abstract: Angular momentum and banking indicator and acceleration-deceleration and grade indicator for use on trucks, cranes, airplanes, and boats as a multipurpose sensor. A cylinder with a damping fluid includes four symmetrically spaced coils centered radially about a centrally located powered coil in a base of the cylinder and a pendulum suspended from a top of the cylinder which swings over the coils. Coils connected to a signal processing system which provides an angular momentum and banking signal and an acceleration and deceleration or grade indicator signal.

Abstract: A pendulum-type accelerometer for use on trucks, cranes, airplanes, and boats as a multipurpose sensor. A cylinder with a damping fluid includes four equally spaced coils in a base of the cylinder and a pendulum suspended from a top of the cylinder which swings over the coils. Coils connected to a signal processing system which provides an angular momentum and banking signal and an acceleration and deacceleration or grade indicator signal.

Abstract: Rate of turn indicator for a nautical vessel, aircraft and the like indicating the rate of turn or swing in units such as degrees per unit of time from a particular course of travel. The indicator includes a magnetic gyro wheel including a flexible hub rotating about an axis in the same plane as the course of travel, and electromagnetic sensing coils receiving the deviations of strength of the electromagnetic field of the magnetic gyro wheel from an axis on turning from the course of travel. The magnetic gyro wheel includes a plurality of permanent magnets of alternating poles positioned about a circumferential axis of a circular member, and a flexible hub material affixed to the interior diameter of the circular member. The hub is affixed to an axially support shaft. The rate of turn indicator includes a meter connected to the electromagnetic sensing coils through electrical circuitry and a potentiometer for zeroing the meter where the meter indicates the rate of turn.

Abstract: Rate of turn indicator for a nautical vessel, aircraft and the like indicating the rate of turn or swing in units such as degrees per unit of time from a particular course of travel. The indicator includes a magnetic gyro wheel including a flexible hub rotating about an axis in the same plane as the course of travel and electromagnetic sensing coils receiving the deviations of strength of the electromagnetic field of the magnetic gyro wheel from an axis on turning from the course of travel. The magnetic gyro wheel includes a plurality of permanent magnets of alternating poles positioned about a circumferential axis of a circular member, and a flexible hub material affixed to the interior diameter of the circular member. The hub is affixed to an axially support shaft. The magnetic gyro wheel is in close proximity to a motor driven nonferrous metallic plate and is driven by eddy currents being induced into the non-ferrous magnetic plate, thus produced.

Abstract: Motor, either synchronous or direct current, including at least one drive coil and including a magnetic rotor having at least two concentric rings of magnetic domains of alternating magnetic poles, with each succeeding rotor ring being of a larger diameter than the previous rotor ring. The drive coil is radially movable so as to be positioned over or adjacent to each of the rotor rings.

Abstract: Rate of turn indicator for a nautical vessel, aircraft, and the like indicating the rate of turn or swing in units such as degrees per unit of time from a particular course of travel. The indicator includes a magnetic gyro wheel including a flexible hub rotating about an axis on the same plane as the course of travel and electromagnetic sensing coils receiving the deviations of strength of the electromagnetic field of the magnetic gyro wheel from an axis on turning from the course of travel. The magnetic gyro wheel includes a plurality of permanent magnets of alternating poles positioned about a circumferential axis of a circular member, and a flexible hub material affixed to the interior diameter of the circular member. The hub is affixed to an axially supported shaft. Adjusting bolts provide for adjusting the distance of the flexible hub magnetic gyro wheel from the electromagnetic sensing coils.