Patents by Inventor Paul Shartzer Dietrich

Paul Shartzer Dietrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable cell lines expressing hERG
    Patent number: 8349572
    Abstract: A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: January 8, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: Paul Shartzer Dietrich, Bruce Koch, Heather Guthrie, Ulrich Andreas Gubler
  • STABLE CELL LINES EXPRESSING HERG
    Publication number: 20100261191
    Abstract: A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided.
    Type: Application
    Filed: June 22, 2010
    Publication date: October 14, 2010
    Inventors: Paul Shartzer Dietrich, Bruce Koch, Heather Guthrie, Ulrich Andreas Gubler
  • Stable cell lines expressing hERG
    Patent number: 7776590
    Abstract: A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: August 17, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Paul Shartzer Dietrich, Bruce Koch, Heather Guthrie, Ulrich Andreas Gubler
  • T-type calcium channel variants; compositions thereof; and uses
    Patent number: 6893842
    Abstract: The invention provides TCCV-1 or TCCV-2 from human, reagents related thereto including polynucleotides encoding TCCV-1 or TCCV-2, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate TCCV-1 or TCCV-2 activity are provided. Also provided are methods of diagnosis and kits.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: May 17, 2005
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Paul Shartzer Dietrich, Joseph Gerrard McGivern
  • T-type calcium channel variants; compositions thereof; and uses
    Publication number: 20030180886
    Abstract: The invention provides TCCV-1 or TCCV-2 from human, reagents related thereto including polynucleotides encoding TCCV-1 or TCCV-2, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate TCCV-1 or TCCV-2 activity are provided. Also provided are methods of diagnosis and kits.
    Type: Application
    Filed: April 29, 2003
    Publication date: September 25, 2003
    Inventors: Paul Shartzer Dietrich, Joseph Gerard McGivern
  • T-type calcium channel variants; compositions thereof; and uses
    Patent number: 6589787
    Abstract: The invention provides TCCV-1 or TCCV-2 from human, reagents related thereto including polynucleotides encoding TCCV-1 or TCCV-2, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate TCCV-1 or TCCV-2 activity are provided. Also provided are methods of diagnosis and kits.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: July 8, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Paul Shartzer Dietrich, Joseph Gerrard McGivern
  • Neuropathic pain genes; compositions thereof; related reagents
    Publication number: 20030003538
    Abstract: The invention provides NPGs from rat and human, reagents related thereto including polynucleotides encoding NPGs, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate NPGs activity are provided. Also provided are methods of diagnosis, kits, and transgenic animals.
    Type: Application
    Filed: May 15, 2002
    Publication date: January 2, 2003
    Inventors: Paul Shartzer Dietrich, Chiao-Chain Huang, Carl D. Johnson, Lakshmi Sangameswaran
  • T-type calcium channel variants; compositions thereof; and uses
    Publication number: 20020150911
    Abstract: The invention provides TCCV-1 or TCCV-2 from human, reagents related thereto including polynucleotides encoding TCCV-1 or TCCV-2, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate TCCV-1 or TCCV-2 activity are provided. Also provided are methods of diagnosis and kits.
    Type: Application
    Filed: August 23, 2001
    Publication date: October 17, 2002
    Inventors: Paul Shartzer Dietrich, Joseph Gerard McGivern
  • Cloned tetrodotoxin-sensitive sodium channel &agr;-subunit and a splice variant thereof
    Patent number: 6335172
    Abstract: DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: January 1, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Stephen Gregory Delgado, Paul Shartzer Dietrich, Linda Marie Fish, Ronald Charles Herman, Lakshmi Sangameswaran
  • T-type calcium channel variants; compositions thereof; and uses
    Patent number: 6309858
    Abstract: The invention provides TCCV-1 or TCCV-2 from human, reagents related thereto including polynucleotides encoding TCCV-1 or TCCV-2, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate TCCV-1 or TCCV-2 activity are provided. Also provided are methods of diagnosis and kits.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: October 30, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Paul Shartzer Dietrich, Joseph Gerard McGivern
  • Cloned tetrodotoxin-sensitive sodium channel .alpha.-subunit and a splice variant thereof
    Patent number: 6030810
    Abstract: DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.
    Type: Grant
    Filed: February 16, 1998
    Date of Patent: February 29, 2000
    Inventors: Stephen Gregory Delgado, Paul Shartzer Dietrich, Linda Marie Fish, Ronald Charles Herman, Lakshmi Sangameswaran