Abstract: An end effector for impacting a prosthesis at a surgical site along a trajectory maintained by a surgical robot. The end effector comprises an impactor assembly and a guide. The impactor assembly has a head to receive impact force, an interface to releasably attach to the prosthesis, a shaft extending along an impactor axis between the head and the interface, and an impactor engagement surface disposed between the head and the interface. The guide is adapted to attach to the surgical robot and comprises a channel extending along a guide axis and defining an opening arranged to receive a portion of the shaft of the impactor assembly, a guide engagement surface shaped to abut the impactor engagement surface, and a limiter to maintain abutment of the impactor engagement surface with the guide engagement surface to facilitate coaxial alignment of the axes with the trajectory maintained by the surgical robot.

Abstract: The present invention provides improved methods and compositions based on microvesicles for the treatment of various diseases, disorders and conditions. In particular, the present invention encompasses the recognition that microvesicles contain specific microRNAs which may function as intercellular regulators involved in cell or tissue regeneration, remodeling, reconstruction, reprogramming or transdifferentiation. Thus, among other things, the present invention provides methods and compositions based on microvesicles and/or associated microRNAs that provide more predictable and effective therapeutic results.

Abstract: A robotic cutting system including a robotic manipulator and a cutting tool coupled to the robotic manipulator. The cutting tool comprises a saw blade. A controller is also coupled to the robotic manipulator. The controller is configured to control operation of the robotic manipulator, the cutting tool, and/or another cutting tool, to cut the bone in an initial stage of cutting until a notch is created in the bone at a predetermined depth. A final stage of cutting is then completed by cutting along the cutting plane.

Abstract: A portable surgical robot includes a surgical device and a cart. The surgical device is coupled to the cart. The cart includes a chassis, a mount coupled to the chassis, a carriage pivotally coupled to the mount, and a set of wheels. The carriage includes a first bracket positioned at a first lateral end of the carriage and a second bracket positioned at a second lateral end of the carriage. A first wheel of the set of wheels is coupled to the first bracket and a second wheel of the set of wheels is coupled to the second bracket. The carriage is configured to pivot relative to the mount to prevent at least one of (i) rocking of the portable surgical robot, (ii) fluttering of the first wheel, (iii) fluttering of the second wheel, and (iv) tipping of the portable surgical robot.

Abstract: A surgical saw blade for being coupled to a drive hub of a surgical saw assembly. The blade includes an attachment portion configured to be removably coupled to the drive hub and a cutting portion opposite the attachment portion. The cutting portion includes a plurality of teeth. The blade also includes a pivot portion configured to engage a pivot structure of the surgical saw assembly. Additionally, the cutting portion has a follower which engages a blade support of the surgical saw assembly and is configured to limit deflection of the blade during use.

Abstract: A tool for positioning a workpiece with a surgical robot. The tool comprises a mount adapted to attach to the surgical robot. A first assembly is provided and extends along an axis. A pivot bearing is coupled to the mount and supports the first assembly for rotation and translation about the axis and for at least partial articulation relative to the mount. A second assembly is provided and comprises an interface adapted to attach to the workpiece. One of the first assembly and the second assembly comprises a coupler and the other of the first assembly and the second assembly comprises a receiver shaped to engage the coupler to align the second assembly and the first assembly along the axis.

Abstract: The present invention provides improved methods and compositions based on microvesicles for the treatment of various diseases, disorders and conditions. In particular, the present invention encompasses the recognition that microvesicles contain specific microRNAs which may function as intercellular regulators involved in cell or tissue regeneration, remodeling, reconstruction, reprogramming or transdifferentiation. Thus, among other things, the present invention provides methods and compositions based on microvesicles and/or associated microRNAs that provide more predictable and effective therapeutic results.

Abstract: Disclosed herein is a clamp attachable to a support rail of a hospital bed, for example. The clamp includes a body, first and second arms coupled to the body, wherein the first and second arms are moveable towards and away from one another. The clamp further includes at least one seat clamp member pivotably coupled to at least one of the first and second arms. The clamp is attached to the support rail when the at least one seat clamp member contacts the support rail and the first and second arms are in a clamped position.

Abstract: A surgical saw blade for being coupled to a drive hub of a surgical saw. The surgical saw blade includes an attachment portion configured to be removably coupled to the drive hub. The surgical saw blade also includes a cutting portion opposite the attachment portion that includes a plurality of teeth. Additionally, the attachment portion defines a pair of indents. The first indent and the second indent are each defined by at least one curved surface. The curved surface is radially outwardly convex.

Abstract: A portable surgical robot includes a surgical device and a cart. The surgical device is coupled to the cart. The cart includes a chassis, a frame member, a pair of wheels, and a steering mechanism. The chassis defines a longitudinal axis that extends a length of the cart. The frame member is coupled to the chassis of the cart. The pair of wheels are pivotably coupled to the frame member. The steering mechanism is coupled to the pair of wheels. The steering mechanism is configured to facilitate selectively pivoting the pair of wheels to steer the cart in a plurality of steering modes. The plurality of steering modes include at least one of a fore-and-aft steering mode, a turn-on-axis steering mode, and a lateral steering mode.

Abstract: A portable surgical robot includes a surgical device and a cart. The surgical device is coupled to the cart. The cart includes a chassis, a mount coupled to the chassis, a carriage pivotally coupled to the mount, and a set of wheels. The carriage includes a first bracket positioned at a first lateral end of the carriage and a second bracket positioned at a second lateral end of the carriage. A first wheel of the set of wheels is coupled to the first bracket and a second wheel of the set of wheels is coupled to the second bracket. The carriage is configured to pivot relative to the mount to prevent at least one of (i) rocking of the portable surgical robot, (ii) fluttering of the first wheel, (iii) fluttering of the second wheel, and (iv) tipping of the portable surgical robot.

Abstract: Disclosed herein is a clamp attachable to a support rail of a hospital bed, for example. The clamp includes a body, first and second arms coupled to the body, wherein the first and second arms are moveable towards and away from one another. The clamp further includes at least one seat clamp member pivotably coupled to at least one of the first and second arms. The clamp is attached to the support rail when the at least one seat clamp member contacts the support rail and the first and second arms are in a clamped position.

Abstract: The present invention provides improved methods and compositions based on microvesicles for the treatment of various diseases, disorders and conditions. In particular, the present invention encompasses the recognition that microvesicles contain specific microRNAs which may function as intercellular regulators involved in cell or tissue regeneration, remodeling, reconstruction, reprogramming or transdifferentiation. Thus, among other things, the present invention provides methods and compositions based on microvesicles and/or associated microRNAs that provide more predictable and effective therapeutic results.

Abstract: A limb positioning system includes a clamp assembly, a pylon and bar assembly, a sled assembly, and a limb positioning assembly. The clamp assembly is configured to attach to a bed rail of a surgical table and to accept a pylon connected to a bar. The pylon may have a plurality of pylon bars that are secured by the clamp assembly. A base bar may extend from the pylon, and may be attachable to an extension bar to provide a longer track along which the sled assembly may slide. The sled assembly may be biased to be locked with respect to the base bar. The limb holding assembly may include a boot coupled to the sled via a connector near the heel. The connector may be tapered and insertable into a correspondingly tapered section of a ball that sits within the sled assembly, the ball being capable of polyaxial motion.

Abstract: The present invention provides, among other things, improved compositions and methods for the treatment of tissue damage (e.g., acute or chronic) and related diseases, disorders or conditions based on the use of pathfinder cells, extracellular secretomes thereof, and/or pathfinder cell-associated microRNAs. In some embodiments, the present invention provides a method for treating tissue damage (e.g., acute or chronic) comprising a step of administering a population of cells to an individual suffering from a disease, disorder or condition characterized by acute damage to one or more tissues, wherein the cells are originated from an adult tissue and wherein the cells induce tissue repair, regeneration, remodeling, reconstitution or differentiation.

Abstract: The invention relates to the provision of a novel cell population that can be used for tissue regeneration and the treatment of disease states associated with cell degeneration for age related tissue changes. The cell population are derived from adult stem/progenitor cells which are characterised by being positive or negative to the Thy1.1 cell marker.

Abstract: The invention relates to the provision of a novel cell population that can be used for tissue regeneration and the treatment of disease states associated with cell degeneration for age related tissue changes. The cell population are derived from adult stem/progenitor cells which are characterised by being positive or negative to the Thy1.1 cell marker.

Abstract: Methods and materials for treating tissues to reduce the risk of transplant rejection are described, along with methods for determining the risk of rejection of transplants. The level of expression of various senescence-associated genes, such as G22P1, XRCC5, hPOT1 and SIRT2 and homologues or analogues thereof, is considered indicative of tissue rejection, and their levels may be modulated to reduce the risk of rejection. The tissue are preferably renal tissues.

Abstract: Apparatus for heating and pouring metal and metal alloys. A metal melting and pouring apparatus suitable for graining the molten material is described. A graphite crucible having at least one exit orifice in its lower, tapered portion, a graphite barrier plate or disk having a plurality of orifices located within the crucible on the tapered portion thereof, and an element for heating the apparatus to temperatures sufficient to melt the metal, have been found to produce a steady stream of consistent droplet-size molten metal, while maintaining a choosen level of liquid metal in the crucible to prevent less dense impurity materials from passing through the exit orifice(s) of the crucible, and to improve the efficiency of melting additional metal subsequently introduced into the crucible.