Patents by Inventor Paul Spence

Paul Spence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120059213
    Abstract: Disclosed herein is a cannula assembly for directing the flow of material from an organ chamber, e.g., blood from the left chamber of the heart, and methods of placing the cannula assembly in fluidic communication with the chamber. The cannula assembly includes an elongate tubular member and a coupling assembly disposed at the distal end of elongate tubular member. The elongate tubular member includes a lumen extending from a distal opening at the distal end to a proximal opening at the proximal end. The coupling assembly includes a retaining element and a retention member configured to cooperate with each other and with the portion of the organ wall surrounding the opening in the wall to couple or anchor cannula system to the wall and to provide fluidic communication between the distal opening of the elongate tubular member and the organ chamber.
    Type: Application
    Filed: September 7, 2011
    Publication date: March 8, 2012
    Inventor: Paul A. Spence
  • Patent number: 8100964
    Abstract: Valve repair apparatus and methods for ensuring proper coaptation and operation of the leaflets of a heart valve. Main aspects of the disclosure relate to devices including a support member configured for attachment to the heart valve annulus, a post extending from the support member away from the plane of the annulus and a connector coupled with the post and configured for attachment to at least one of the leaflets. The various embodiments may include a replacement heart valve connected with the support member for facilitating full replacement as opposed to near repair of an existing native heart valve. Various other devices include support structure and one or more posts connected to opposite sides of the support structure and extending from one side of the valve annulus to another to modify the shape of the annulus.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: January 24, 2012
    Assignee: Cardiac Valve Technologies LLC
    Inventor: Paul A. Spence
  • Patent number: 8092364
    Abstract: Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a first conduit while the heart is in systole and expel the blood into the first conduit and the artery while the heart is in diastole.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: January 10, 2012
    Inventor: Paul A. Spence
  • Publication number: 20110230432
    Abstract: Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
    Type: Application
    Filed: May 26, 2011
    Publication date: September 22, 2011
    Applicant: Adamas Pharmaceuticals, Inc.
    Inventors: Jack Nguyen, Gregory T. Went, Paul Spence, Timothy J. Fultz, David Chernoff
  • Publication number: 20110224582
    Abstract: A system for directing ultrasonic energy through blood flow in the aorta of a patient proximate the origins of the great vessels to the head of the patient to divert material in the blood flow from the origins of the great vessels. The system includes a first device configured for introduction into the cardiovascular system of the patient and positioning proximate the origins of the great vessels to the head of the patient, and at least one ultrasonic energy emitter carried by the first device.
    Type: Application
    Filed: May 24, 2011
    Publication date: September 15, 2011
    Inventor: Paul A. Spence
  • Publication number: 20110218621
    Abstract: A device for repairing a heart valve comprises an implantation instrument. The implantation instrument comprises a first support ring, and a second support ring connected to said first support ring to form a coiled configuration. The first support ring is configured to abut one side of the valve and the second support ring is configured to abut an opposite side of the valve to thereby trap a portion of the valve tissue therebetween. The device further comprises an annuloplasty implant adapted to be attached to the heart valve annulus in order to reshape the annulus and allow the leaflets to open and close properly. The annuloplasty implant is connected to the implantation instrument for insertion to the annulus.
    Type: Application
    Filed: May 16, 2011
    Publication date: September 8, 2011
    Inventors: Per Antonsson, Paul A. Spence
  • Patent number: 7981930
    Abstract: Kits comprising an M2 inhibitor selected from amantadine and rimantadine; ribavirin, and a neuraminidase inhibitor (NAi) in an amount that is antivirally effective in the combination, an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin and a neuraminidase inhibitor are provided for the treatment of influenza. Some embodiments of the kits comprise an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin, and a neuraminidase inhibitor.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: July 19, 2011
    Assignee: Adamas Pharmaceuticals, Inc.
    Inventors: Jack Nguyen, Gregory T. Went, Paul Spence, Timothy J. Fultz, David Chernoff, Terry L. Burkoth, Rowan Chapman, Mickey S. Urdea
  • Patent number: 7951195
    Abstract: A device for repairing a heart valve comprises an implantation instrument. The implantation instrument comprises a first support ring, and a second support ring connected to said first support ring to form a coiled configuration. The first support ring is configured to abut one side of the valve and the second support ring is configured to abut an opposite side of the valve to thereby trap a portion of the valve tissue therebetween. The device further comprises an annuloplasty implant adapted to be attached to the heart valve annulus in order to reshape the annulus and allow the leaflets to open and close properly. The annuloplasty implant is connected to the implantation instrument for insertion to the annulus.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: May 31, 2011
    Assignee: Medtentia International Ltd. OY
    Inventors: Per Antonsson, Paul A. Spence
  • Patent number: 7858660
    Abstract: Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: December 28, 2010
    Assignee: Adamas Pharmaceuticals, Inc.
    Inventors: Jack Nguyen, Gregory T. Went, Paul Spence, Timothy J. Fultz, David Chernoff, Terry L. Burkoth, Rowan Chapman, Mickey S. Urdea
  • Publication number: 20100324669
    Abstract: The present invention relates to a minimally invasive method of performing annuloplasty. According to one aspect of the present invention, a method for performing annuloplasty includes accessing a left ventricle of a heart to provide a discrete plication element to the left ventricle, and engaging the plication element to tissue near a mitral valve of the heart. Engaging the plication element includes causing the plication element to gather a portion of the tissue to create a plication. In one embodiment, accessing the left ventricle of the heart to provide the plication element includes accessing the left ventricle of the heart using a catheter arrangement.
    Type: Application
    Filed: August 2, 2010
    Publication date: December 23, 2010
    Applicant: Mitralign, Inc.
    Inventors: Edwin J. Hlavka, Jonathan L. Podmore, Paul A. Spence
  • Publication number: 20100318184
    Abstract: Valve repair apparatus and methods for ensuring proper coaptation and operation of the leaflets of a heart valve. Main aspects of the disclosure relate to devices including a support member configured for attachment to the heart valve annulus, a post extending from the support member away from the plane of the annulus and a connector coupled with the post and configured for attachment to at least one of the leaflets. The various embodiments may include a replacement heart valve connected with the support member for facilitating full replacement as opposed to near repair of an existing native heart valve. Various other devices include support structure and one or more posts connected to opposite sides of the support structure and extending from one side of the valve annulus to another to modify the shape of the annulus.
    Type: Application
    Filed: August 18, 2010
    Publication date: December 16, 2010
    Inventor: Paul A. Spence
  • Publication number: 20100280306
    Abstract: Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a first conduit while the heart is in systole and expel the blood into the first conduit and the artery while the heart is in diastole.
    Type: Application
    Filed: June 30, 2010
    Publication date: November 4, 2010
    Inventor: Paul A. Spence
  • Patent number: 7766813
    Abstract: Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a first conduit while the heart is in systole and expel the blood into the first conduit and the artery while the heart is in diastole.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: August 3, 2010
    Inventor: Paul A. Spence
  • Publication number: 20100160431
    Abstract: Compositions for treating flu comprise an M2 inhibitor, and optionally a neuraminidase inhibitor, wherein at least one of said M2 inhibitor or said neuraminidase inhibitor is provided in an extended release dosage form.
    Type: Application
    Filed: August 20, 2009
    Publication date: June 24, 2010
    Inventors: Gregory Went, David Chernoff, Paul Spence, Terry Burkoth, Timothy Fultz
  • Patent number: 7722642
    Abstract: Wire fasteners having legs with lengths that can be one hundred times the width of the fastener are used to secure items, such as prosthesis valves to a patient during minimally invasive surgery. The fasteners are manipulated into position and then are immobilized by means of the legs thereof for tensioning, cutting and forming in situ. The fasteners are manipulated, tensioned and formed from the leg end of the fasteners. Tools for initially placing the fasteners and for immobilizing, tensioning, cutting and bending the fastener legs are disclosed. Once the fasteners are initially placed, the prosthesis is placed on the long legs of the placed fasteners and is guided into position on the legs. Once the prosthesis is in position, the legs of the fasteners are immobilized, tensioned, cut and bent into staple-like shapes to secure the prosthesis to the patient. A method for carrying out the procedure using the long fastener is also disclosed.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: May 25, 2010
    Assignee: Medtronic, Inc.
    Inventors: Warren P. Williamson, IV, Paul A. Spence, George A. Keller, Cecil R. Robinson, Thomas J. Ward
  • Publication number: 20090326978
    Abstract: Stockpiles and methods of stockpiling a combination antiviral therapy for responding to an epidemic viral outbreak are described. Methods and systems of inventory control for co-deployment of drugs used in combination during a pandemic are described.
    Type: Application
    Filed: June 30, 2009
    Publication date: December 31, 2009
    Inventors: Timothy J. Fultz, Gregory T. Went, Jack Nguyen, Paul Spence, David Chernoff, Terry L. Burkoth, Rowan Chapman, Mickey S. Urdea
  • Publication number: 20090247481
    Abstract: Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
    Type: Application
    Filed: June 2, 2009
    Publication date: October 1, 2009
    Applicant: ADAMAS PHARMACEUTICALS, INC.
    Inventors: Jack Nguyen, Gregory T. Went, Paul Spence, Timothy J. Fultz, David Chernoff, Terry L. Burkoth, Rowan Chapman, Mickey S. Urdea
  • Publication number: 20090177278
    Abstract: Valve repair apparatus and methods for ensuring proper coaptation and operation of the leaflets of a heart valve. Main aspects of the disclosure relate to devices including a support member configured for attachment to the heart valve annulus, a post extending from the support member away from the plane of the annulus and a connector coupled with the post and configured for attachment to at least one of the leaflets. The various embodiments may include a replacement heart valve connected with the support member for facilitating full replacement as opposed to near repair of an existing native heart valve. Various other devices include support structure and one or more posts connected to opposite sides of the support structure and extending from one side of the valve annulus to another to modify the shape of the annulus.
    Type: Application
    Filed: March 13, 2009
    Publication date: July 9, 2009
    Inventor: Paul A. Spence
  • Patent number: 7527647
    Abstract: Valve repair apparatus and methods for ensuring proper coaptation and operation of the leaflets of a heart valve. Main aspects of the disclosure relate to devices including a support member configured for attachment to the heart valve annulus, a post extending from the support member away from the plane of the annulus and a connector coupled with the post and configured for attachment to at least one of the leaflets. The various embodiments may include a replacement heart valve connected with the support member for facilitating full replacement as opposed to near repair of an existing native heart valve. Various other devices include support structure and one or more posts connected to opposite sides of the support structure and extending from one side of the valve annulus to another to modify the shape of the annulus.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: May 5, 2009
    Inventor: Paul A. Spence
  • Publication number: 20090099412
    Abstract: A system for manipulating a heart during cardiac surgery permits coronary surgery on a beating heart while maintaining cardiac output unabated and uninterrupted. Circumflex coronary artery surgery can be performed using the system. A component of the system engages the heart with a heart positioning device, repositions the heart into a displaced position and maintains it in the displaced position while the heart continues to beat with substantially unabated and uninterrupted cardiac output. One form of the system can be used in minimally invasive surgery.
    Type: Application
    Filed: December 16, 2008
    Publication date: April 16, 2009
    Inventors: Paul A. Spence, Warren P. Williamson, IV, Mark Ortiz