Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A method of manufacturing a core for a composite material sandwich panel, the method comprising the steps of: providing a sheet of balsawood with opposite major surfaces, with vessels and axial parenchyma cells of the balsawood extending between the opposite major surfaces in a thickness direction of the sheet; coating a layer of a curable resin composition onto respective opposite major surfaces of the sheet of balsawood; and curing the curable resin composition, wherein the resin composition is applied and cured so that the coating layer of cured resin composition unevenly fills or only partly fills outermost ends of at least some of the vessels in the balsawood and thereby provides, at least in the vicinity of at least some of the vessels, a non-planar outer surface of the coating layer of the cured resin composition over the opposite major surfaces.

Abstract: A prepreg having at least one layer of fibres and a curable thermosetting resin system at least partly impregnating the at least one layer of fibres, wherein the curable thermosetting resin system includes a curable thermosetting resin including at least two epoxide groups, a curing agent that includes at least one amine group, and an accelerator that includes an azole group; wherein the curable thermosetting resin, the curing agent and the accelerator are provided in respective concentrations in the prepreg to provide that, after curing the thermosetting resin at a cure temperature of at least 140° C. for a period of from 1 to 6 minutes, (i) the cured thermosetting resin has a glass transition temperature Tg which is greater than the cure temperature and is within the range of from 150° C. to 180° C. and (ii) the cured thermosetting resin is at least 90% cured.

Abstract: A medical image processing apparatus comprises smoothing circuitry that receives a volumetric medical image data set corresponding to a 3D region of a subject and smooths the volumetric medical image data set to generate a smoothed medical image data set, wherein at least one part of the surface of a structure is represented in the volumetric medical image data set, rendering circuitry that produces a 2D rendered data set from the smoothed medical image data set, curvature calculation circuitry that calculates a respective curvature at each of a plurality of positions on the at least one part of the surface of the structure and smooths the calculated curvatures to obtain smoothed calculated curvatures, and shading addition circuitry that adds shading to the 2D rendered data set in dependence on the smoothed calculated curvatures.

Abstract: A vehicle headlamp aiming system includes a displaceable aiming surface and an imaging system. The imaging system includes an indexing aim box having at least one imager oriented to capture images of a headlamp and/or one or more vehicle features adjacent to the headlamp and at least one fixed imager oriented to capture one images of the displaceable aiming surface to determine a headlamp cutoff height. The displaceable aiming surface is configured to selectively displace to allow passage of the vehicle. The indexing aim box is configured to translate between the headlamp and another headlamp. One or more computing devices are configured to perform methods for headlamp aim correction using the described system. The methods include providing image inputs from the imaging system and calculating therefrom an aim correction of the headlamps.

Abstract: A system for aiming a headlamp of a vehicle includes a displaceable aiming surface and an imaging system. The imaging system includes a translatable aim box carrying at least one headlamp imager oriented to capture images of a single headlamp and/or one or more vehicle features adjacent to the single headlamp. At least one fixed imager is oriented to capture one or more images of the displaceable aiming surface. The translatable aim box may be configured to translate between the single headlamp and another headlamp. One or more computing devices are configured to perform methods for headlamp aim correction using the described system. Methods for headlamp aim correction are described.

Abstract: A vehicle headlamp aiming system includes a displaceable aiming surface and an imaging system. The imaging system includes an indexing aim box having at least one imager oriented to capture images of a headlamp and/or one or more vehicle features adjacent to the headlamp and at least one fixed imager oriented to capture one images of the displaceable aiming surface to determine a headlamp cutoff height. The displaceable aiming surface is configured to selectively displace to allow passage of the vehicle. The indexing aim box is configured to translate between the headlamp and another headlamp. One or more computing devices are configured to perform methods for headlamp aim correction using the described system. The methods include providing image inputs from the imaging system and calculating therefrom an aim correction of the headlamps.

Abstract: The invention is directed to methods of treatment using compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to certain novel compounds. Specifically, crystalline forms of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide and crystalline 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole, along with salts thereof.

Abstract: A medical image processing apparatus comprises smoothing circuitry that receives a volumetric medical image data set corresponding to a 3D region of a subject and smooths the volumetric medical image data set to generate a smoothed medical image data set, wherein at least one part of the surface of a structure is represented in the volumetric medical image data set, rendering circuitry that produces a 2D rendered data set from the smoothed medical image data set, curvature calculation circuitry that calculates a respective curvature at each of a plurality of positions on the at least one part of the surface of the structure and smooths the calculated curvatures to obtain smoothed calculated curvatures, and shading addition circuitry that adds shading to the 2D rendered data set in dependence on the smoothed calculated curvatures.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: A prepreg for manufacturing a fibre-reinforced composite material, the prepreg including a body having a layer of fibrous reinforcement impregnated with a matrix resin material, and a powder coating layer of resin material on at least one major surface of the body and at least partly fused to the matrix resin material

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.

Abstract: A method of manufacturing a core for a composite material sandwich panel, the method comprising the steps of: providing a sheet of balsawood with opposite major surfaces, with vessels and axial parenchyma cells of the balsawood extending between the opposite major surfaces in a thickness direction of the sheet; coating a layer of a curable resin composition onto respective opposite major surfaces of the sheet of balsawood; and curing the curable resin composition, wherein the resin composition is applied and cured so that the coating layer of cured resin composition unevenly fills or only partly fills outermost ends of at least some of the vessels in the balsawood and thereby provides, at least in the vicinity of at least some of the vessels, a non-planar outer surface of the coating layer of the cured resin composition over the opposite major surfaces.

Abstract: Described herein are systems and methods for reducing power consumption, latency, and chip complexity in a datacom/telecom multiplexer and demultiplexer. Adding a high frequency analog domain data path around or in place of a standard digital core data path allows the elimination of the demultiplexing and multiplexing stages required to drop the data rate of data streams down to that required for a standard digital core. Latency is also reduced due to the higher operating frequency of sequential elements required for data operations. The digital core can be powered down when not in use, and can be activated when necessary.

Abstract: The invention provides a combination comprising compounds of formula (I) or salts thereof, and one or more therapeutic agents.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: An adjustable lift truck having a frame with a first end and an opposing second end. The frame defines a longitudinal axis that extends from the first end to the second end. A pair of transport wheels are rotatably mounted to the frame proximate the first end. A pair of laterally spaced-apart outriggers extend generally perpendicularly to the longitudinal axis of the frame. Each outrigger is located proximate the first end of the frame, and includes a first end pivotally attached to the frame and an opposing free second end.