Patents by Inventor Paul Spevak

Paul Spevak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Economical manufacturing process for 1,2,3-triazoles
    Patent number: 5527920
    Abstract: A high quality 1,2,3-triazole is obtained in a one pot two step reaction between appropriately substituted hydrazide derivatives, dihaloethanediol and NH.sub.3 in methanol. Synthesis of various N.sub.1 -alkyl, N.sub.1 -aryl, and N.sub.1 -heterocyclic-1,2,3-triazoles is also accomplished following the same general procedure.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: June 18, 1996
    Inventors: Inder P. Singh, Paul Spevak, Bhupinder Palak, Samuel Amedjo, Ronald G. Micetich
  • Effective process for the production of 1,2,3-triazoles
    Patent number: 5478947
    Abstract: A high purity triazole is obtained by the reaction of a hydrazide of the general formula II and glyoxal followed by the treatment of the intermediate of general formula IV with ammonia. The total process is done in one pot and does not require the isolation of the intermediate IV. The triazole (I) is isolated by distillation. Synthesis of various N.sub.1 -substituted triazoles is also described following the same procedure.
    Type: Grant
    Filed: July 29, 1994
    Date of Patent: December 26, 1995
    Assignee: SynPhar Laboratories, Inc.
    Inventors: Inder P. Singh, Paul Spevak, Bhupinder Palak, Samuel Amedjo, Ronald J. Micetich
  • 2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents
    Patent number: 5446037
    Abstract: This invention relates to 2-[(substituted)methylene]cephalosporin sulfones and in particular 2-[(heteroaryl substituted)methylene]cephalosporin sulfones which are effective elastase inhibitors as well as effective thrombin inhibitors and therefore are useful as anti-inflammatory, anti-degenerative and anti-thrombin agents.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: August 29, 1995
    Assignee: Synphar Laboratories, Inc.
    Inventors: Samarendra Maiti, Charles Fiakpui, A. V. N. Reddy, David Czajkowski, Paul Spevak, Harninder Atwal, Ronald G. Micetich
  • 2-spirocyclopropyl cephalosporin sulfone derivatives
    Patent number: 5264430
    Abstract: Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula I ##STR1## are provided which are useful as potent elastase inhibitors.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: November 23, 1993
    Assignee: SynPhar Laboratories, Inc.
    Inventors: Samarendra N. Maiti, David Czajkowski, Paul Spevak, Kazuo Adachi, Ronald G. Micetich
  • 2-spirocyclopropyl cephalosporin sulfone derivatives
    Patent number: 5264429
    Abstract: Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula I ##STR1## are provided which are useful as potent elastase inhibitors.
    Type: Grant
    Filed: August 20, 1991
    Date of Patent: November 23, 1993
    Assignee: SynPhar Laboratories, Inc.
    Inventors: Samarendra N. Maiti, David Czajkowski, Paul Spevak, Kazuo Adachi, Ronald G. Micetich
  • 2-spirocyclopropyl 4-acylcephems
    Patent number: 5258377
    Abstract: Derivatives of 2-spirocyclopropyl 4-acylcephem sulfones of the formula (I) ##STR1## are provided which are useful as potent elastase inhibitors and hence are useful in the prevention, control and treatment of inflammatory conditions, especially arthritis and emphysema.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: November 2, 1993
    Assignee: Taiho Pharmaceutical Co., Ltd.
    Inventors: Samarendra N. Maiti, Narender A. V. Reddy, David Czajkowski, Paul Spevak, Charles Fiakpui, Ronald G. Micetich