Patents by Inventor Paul Sprengeler

Paul Sprengeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolinone-based compounds
    Patent number: 5514814
    Abstract: This invention relates to monomeric and polymeric pyrrolinone-based compounds, to the use of pyrrolinone-based compounds in place of amino acids in naturally-occurring or synthetic peptides, and to methods for preparing such compounds.
    Type: Grant
    Filed: November 8, 1994
    Date of Patent: May 7, 1996
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Ralph F. Hirschmann, Amos B. Smith, III, Paul Sprengeler, David Jones
  • Pyrrolinone-based compounds
    Patent number: 5489692
    Abstract: Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: February 6, 1996
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, Amos B. Smith, III, Paul Sprengeler, Ryan C. Holcomb, Terence Keenan, John L. Wood, Mark Guzman
  • Aromatic peptidomimetics
    Patent number: 5250564
    Abstract: Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 comprises a chemical functional group which causes the compounds to be crossreactive with the peptide of interest.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: October 5, 1993
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, Ellen Leahy, Paul Sprengeler