Patents by Inventor Paul Stabach

Paul Stabach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Soluble ENPP1 proteins and uses thereof
    Patent number: 12698487
    Abstract: In certain aspects, the present invention provides novel soluble ENPP1 or ENPP3 polypeptides, as well as compositions and methods for using those variants to treat an indication associated an ENPP1 or ENPP3 deficiency. The compositions and methods provided herein are useful in treating diseases associated with an ENPP1 or ENPP3 deficiency such as pathological calcification or pathological ossification.
    Type: Grant
    Filed: December 8, 2022
    Date of Patent: August 4, 2026
    Assignees: BIOMARIN PHARMACEUTICAL INC., Yale University
    Inventors: Zhiliang Cheng, Demetrios Braddock, Paul Stabach, Steven Jungles
  • COMPOSITIONS AND METHODS FOR TREATING, AMELIORATING, AND/OR PREVENTING DISEASES AND/OR DISORDERS
    Publication number: 20260083828
    Abstract: The present disclosure includes compositions and methods for treating, ameliorating, and/or preventing certain diseases and/or disorders associated with associated with DNAse1 and/or DNAse1L3 deficiency.
    Type: Application
    Filed: September 11, 2025
    Publication date: March 26, 2026
    Inventors: Demetrios Braddock, Paul Stabach, Ethan Lester
  • ENPP1 Polypeptides and Methods of Using Same
    Publication number: 20260049294
    Abstract: The present invention includes ENPP1 polypeptides with improved in vivo half-lives.
    Type: Application
    Filed: June 2, 2025
    Publication date: February 19, 2026
    Inventors: Paul Stabach, Demetrios Braddock
  • ENPP1 POLYPEPTIDES AND METHODS OF USING SAME
    Publication number: 20250230423
    Abstract: The present disclosure includes ENPP1 mutant polypeptides with improved in vivo half-lives.
    Type: Application
    Filed: August 26, 2024
    Publication date: July 17, 2025
    Inventors: Paul Stabach, Demetrios Braddock
  • ENPP1 polypeptides and methods of using same
    Patent number: 12344868
    Abstract: The present invention includes ENPP1 polypeptides with improved in vivo half-lives. The invention further provides an ENPP1 polypeptide fusion comprising an ENPP1 polypeptide fused to a Fc region of an immunoglobulin, wherein the polypeptide fusion comprises at least one point mutation.
    Type: Grant
    Filed: August 31, 2019
    Date of Patent: July 1, 2025
    Assignee: YALE UNIVERSITY
    Inventors: Paul Stabach, Demetrios Braddock
  • COMPOSITIONS AND METHODS FOR TREATING, AMELIORATING, AND/OR PREVENTING DISEASES OR DISORDERS CAUSED BY OR ASSOCIATED WITH DNASE1 AND/OR DNASE1L3 DEFICIENCY
    Publication number: 20230416358
    Abstract: The present disclosure includes novel DNAse1 and/or DNAse1L3 constructs with improved in vivo half-lives, enzymatic stability, and/or developability properties.
    Type: Application
    Filed: July 18, 2023
    Publication date: December 28, 2023
    Inventors: Paul Stabach, Demetrios Braddock
  • SOLUBLE ENPP1 PROTEINS AND USES THEREOF
    Publication number: 20230313158
    Abstract: In certain aspects, the present invention provides novel soluble ENPP1 or ENPP3 polypeptides, as well as compositions and methods for using those variants to treat an indication associated an ENPP1 or ENPP3 deficiency. The compositions and methods provided herein are useful in treating diseases associated with an ENPP1 or ENPP3 deficiency such as pathological calcification or pathological ossification.
    Type: Application
    Filed: December 8, 2022
    Publication date: October 5, 2023
    Inventors: Zhiliang Cheng, Demetrios Braddock, Paul Stabach, Steven Jungles
  • COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING COAGULOPATHY AND/OR SEPSIS IN PATIENTS SUFFERING FROM BACTERIAL AND/OR VIRAL INFECTIONS
    Publication number: 20230226158
    Abstract: The present disclosure includes compositions and methods for treating, ameliorating, and/or preventing immune mediated pathology associated with a bacterial and/or viral infection.
    Type: Application
    Filed: June 8, 2021
    Publication date: July 20, 2023
    Inventors: Paul Stabach, Demetrios Braddock
  • COMPOSITIONS AND METHODS FOR TREATING, AMELIORATING, AND/OR PREVENTING DISEASES OR DISORDERS CAUSED BY OR ASSOCIATED WITH DNASE1 AND/OR DNASE1L3 DEFICIENCY
    Publication number: 20230062096
    Abstract: The present disclosure includes novel DNAse1 and/or DNAse1L3 constructs with improved in vivo half-lives, enzymatic stability, and/or developability properties.
    Type: Application
    Filed: January 11, 2021
    Publication date: March 2, 2023
    Inventors: Paul Stabach, Demetrios Braddock
  • ENPP1 POLYPEPTIDES AND METHODS OF USING SAME
    Publication number: 20220195402
    Abstract: The present disclosure includes ENPP1 mutant polypeptides with improved in vivo half-lives.
    Type: Application
    Filed: April 3, 2020
    Publication date: June 23, 2022
    Inventors: Paul Stabach, Demetrios Braddock
  • ENPP1 Polypeptides and Methods of Using Same
    Publication number: 20220119782
    Abstract: The present invention includes ENPP1 polypeptides with improved in vivo half-lives. The invention further provides an ENPP1 polypeptide fusion comprising an ENPP1 polypeptide fused to a Fc region of an immunoglobulin, wherein the polypeptide fusion comprises at least one point mutation.
    Type: Application
    Filed: August 31, 2019
    Publication date: April 21, 2022
    Inventors: Paul Stabach, Demetrios Braddock