Patents by Inventor Paul Stack

Paul Stack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
    Patent number: 7041697
    Abstract: Compounds of the Formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: May 9, 2006
    Assignee: Wyeth
    Inventors: Deborah Ann Evrard, Uresh Shantilal Shah, Gary Paul Stack
  • Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
    Patent number: 6939877
    Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: September 6, 2005
    Assignee: Wyeth
    Inventors: Michael Bryon Webb, Gary Paul Stack, Magda Asselin, Deborah A. Evrard
  • Antidepressant azaheterocyclymethyl derivatives of 4,5-dihydroimidazo[1,4,5-de][1,4]benzoxazine
    Patent number: 6919334
    Abstract: Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: July 19, 2005
    Assignee: Wyeth
    Inventors: Hong Gao, Gary Paul Stack
  • Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
    Patent number: 6911445
    Abstract: Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: June 28, 2005
    Assignee: Wyeth
    Inventors: Deborah Ann Evrard, Gary Paul Stack, Uresh Shantilal Shah
  • Dihydrodipyrazolopyridinone inhibitors of B7-1
    Patent number: 6900223
    Abstract: The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection, autoimmune disease or graft vs. host disease.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: May 31, 2005
    Assignee: Wyeth
    Inventors: Neal Jeffrey Green, Steve Yikkai Tam, Jason Shaoyun Xiang, Audrey Molina Davies, Lihren Chen, Gary Paul Stack
  • Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
    Patent number: 6800637
    Abstract: Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: October 5, 2004
    Assignee: Wyeth
    Inventors: Gary Paul Stack, Michael Byron Webb, Deborah Ann Evrard, Dahul Zhou
  • Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
    Publication number: 20040171667
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: September 10, 2003
    Publication date: September 2, 2004
    Inventors: Deborah Ann Evrard, Gary Paul Stack, Uresh Shantilal Shah
  • Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
    Publication number: 20040147523
    Abstract: Compounds of the Formula: 1
    Type: Application
    Filed: September 10, 2003
    Publication date: July 29, 2004
    Inventors: Michael Byron Webb, Gary Paul Stack, Magda Asselin, Deborah A. Evrard
  • Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans
    Publication number: 20040142926
    Abstract: Compounds of the formula I: 1
    Type: Application
    Filed: September 10, 2003
    Publication date: July 22, 2004
    Inventors: Deborah Ann Evrard, Dahui Zhou, Gary Paul Stack, Aranapakam Madumbai Venkatesan, Amedeo A. Failli, Susan Christman Croce
  • Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
    Publication number: 20040138222
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: September 10, 2003
    Publication date: July 15, 2004
    Inventors: Gary Paul Stack, Michael Byron Webb, Deborah Ann Evrard, Dahui Zhou
  • Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
    Publication number: 20040132714
    Abstract: Compounds of the Formula: 1
    Type: Application
    Filed: September 10, 2003
    Publication date: July 8, 2004
    Inventors: Dahui Zhou, Gary Paul Stack
  • Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
    Publication number: 20040127543
    Abstract: Compounds of the Formula I: 1
    Type: Application
    Filed: September 10, 2003
    Publication date: July 1, 2004
    Inventors: Deborah Ann Evrard, Uresh Shantilal Shah, Gary Paul Stack
  • Antidepressant azaheterocyclylmethyl derivatives of 4,5-dihydroimidazo[1,4,5-de ][1,4]benzoxazine
    Publication number: 20040127493
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: September 10, 2003
    Publication date: July 1, 2004
    Inventors: Hong Gao, Gary Paul Stack
  • Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport
    Patent number: 6750364
    Abstract: This invention provides compounds of the formula: wherein X is (CH2)n, O, S, SO, SO2 or CR1R2; n is 1 or 2; R1 and R2 are H, halogen, hydroxy, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or R1 and R2, taken together form cycloalkyl of 3 to 6 carbon atoms, an alkylidene of up to 6 carbon atoms or a carbonyl; R3, R4 and R5 are H or alkyl of 1 to 6 carbon atoms; Z is H, alkyl of 1 to 6 carbon atoms, alkanoyl of 1 to 6 carbon atoms or alkoxycarbonyl of 2 to 7 carbon atoms; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods for their use in treating or preventing characterized by glutamate hypofunction, including schizophrenia, schizoaffective disorder and schizophreniform disorder, and for the treatment of cognitive deficits due to aging, stroke, Alzheimer's disease or other neurodegenerative diseases.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: June 15, 2004
    Assignee: Wyeth
    Inventors: Gary Paul Stack, John Dunlop, Alexander Alexei Greenfield, Jonathan Laird Gross
  • Dihydrodipyrazolopyridinone inhibitors of B7-1
    Publication number: 20040044024
    Abstract: The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection, autoimmune disease or graft vs. host disease.
    Type: Application
    Filed: July 28, 2003
    Publication date: March 4, 2004
    Applicant: Wyeth
    Inventors: Neal Jeffrey Green, Steve Yikkai Tam, Jason Shaoyun Xiang, Audrey Molina Davies, Lihren Chen, Gary Paul Stack
  • Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
    Patent number: 6667322
    Abstract: Compounds of the formula useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: December 23, 2003
    Assignee: Wyeth
    Inventors: Jonathan Laird Gross, Richard Eric Mewshaw, Gary Paul Stack
  • Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
    Publication number: 20030100579
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: October 4, 2002
    Publication date: May 29, 2003
    Applicant: Wyeth
    Inventors: Jonathan Laird Gross, Richard Eric Mewshaw, Gary Paul Stack
  • Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4
    Publication number: 20030027771
    Abstract: Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Application
    Filed: May 7, 2002
    Publication date: February 6, 2003
    Inventors: Darren B. Dressen, Anthony Kreft, Dennis Kubrak, Charles William Mann, Michael A. Pleiss, Gary Paul Stack, Eugene D. Thorsett
  • Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport
    Publication number: 20030022930
    Abstract: This invention provides compounds of the formula: 1
    Type: Application
    Filed: June 27, 2002
    Publication date: January 30, 2003
    Applicant: Wyeth
    Inventors: Gary Paul Stack, John Dunlop, Alexander Alexei Greenfield, Jonathan Laird Gross
  • Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4
    Patent number: 6407066
    Abstract: Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: June 18, 2002
    Assignees: Elan Pharmaceuticals, Inc., American Home Products Corporation
    Inventors: Darren B. Dressen, Anthony Kreft, Dennis Kubrak, Charles William Mann, Michael A. Pleiss, Gary Paul Stack, Eugene D. Thorsett