Abstract: Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.

Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.

Abstract: Filter elements, filter mounting systems, filter systems, methods of servicing filter systems, and methods of mounting filter elements are provided herein. The mounting system may include a quick attach attachment member that can be both axially slid along a mounting shank as well as threadedly engaged therewith. Torque limiting features may be provided to limit the amount of loading that may be provided by an attachment member to a filter element. Identifiers of appropriate tightening of attachment members may be provided. Clocking features and mechanisms for better balancing loading on seal members may be provided.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.

Abstract: The present invention relates to a cytochrome P450 enzyme comprising the amino acid sequence set forth in SEQ ID NO: 3, or a variant thereof having an amino acid sequence having at least 95% identity thereto and having CYP450 activity. The cytochrome P450 enzyme provided herein was isolated from Streptomyces eurythermus NRRL 2539 and has a wide substrate range and high activity, and may be used to oxidate organic compounds.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.

Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.

Abstract: A fluid delivery device for a hydraulic fracturing system includes a fluid conduit having a fracking fluid outlet configured to be fluidly connected to a well head for delivering a fracking fluid to the well head. The fluid conduit includes a base fluid inlet configured to be fluidly connected to the outlet of a frac pump such that the fluid conduit is configured to receive a flow of base fluid from the frac pump. An injection system is fluidly connected to the fluid conduit downstream from the base fluid inlet and upstream from the fracking fluid outlet. The injection system is configured to be fluidly connected to a material source. The injection system is configured to inject at least one material of the fracking fluid from the material source into the fluid conduit downstream from the frac pump to generate the fracking fluid within the fluid conduit.

Abstract: A fluid delivery device for a hydraulic fracturing system includes a fluid conduit having a fracking fluid outlet configured to be fluidly connected to a well head for delivering a fracking fluid to the well head. The fluid conduit includes a base fluid inlet configured to be fluidly connected to the outlet of a frac pump such that the fluid conduit is configured to receive a flow of base fluid from the frac pump. An injection system is fluidly connected to the fluid conduit downstream from the base fluid inlet and upstream from the fracking fluid outlet. The injection system is configured to be fluidly connected to a material source. The injection system is configured to inject at least one material of the fracking fluid from the material source into the fluid conduit downstream from the frac pump to generate the fracking fluid within the fluid conduit.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.

Abstract: The present application provides a filtration system for a gas turbine engine. The filtration system may include a holding frame with a positioning element extending therefrom and a filtration unit for mounting within the holding frame. The filtration unit may include a positioning slot therein such that the positioning element extends through the positioning slot when the filtration unit is mounted within the holding frame.

Abstract: A fluid delivery device for a hydraulic fracturing system includes a fluid conduit having a fracking fluid outlet configured to be fluidly connected to a well head for delivering a fracking fluid to the well head. The fluid conduit includes a base fluid inlet configured to be fluidly connected to the outlet of a frac pump such that the fluid conduit is configured to receive a flow of base fluid from the frac pump. An injection system is fluidly connected to the fluid conduit downstream from the base fluid inlet and upstream from the fracking fluid outlet. The injection system is configured to be fluidly connected to a material source. The injection system is configured to inject at least one material of the fracking fluid from the material source into the fluid conduit downstream from the frac pump to generate the fracking fluid within the fluid conduit.

Abstract: Systems and methods for motion capture of a subject, suitable for use in an underground mining environment.

Abstract: The present application provides a filtration system for a gas turbine engine. The filtration system may include a holding frame with a positioning element extending therefrom and a filtration unit for mounting within the holding frame. The filtration unit may include a positioning slot therein such that the positioning element extends through the positioning slot when the filtration unit is mounted within the holding frame.

Abstract: The present application provides a filtration system for a gas turbine engine. The filtration system may include a holding frame with a positioning element extending therefrom and a filtration unit for mounting within the holding frame. The filtration unit may include a positioning slot therein such that the positioning element extends through the positioning slot when the filtration unit is mounted within the holding frame.

Abstract: A device, which may have a touchscreen display, and methods for its operation are provided using a graphical user interface and an overlay user input interface such as a virtual keyboard. The graphical user interface may include one or more user interface elements displayed in a first region of the display that are actuatable to invoke a corresponding function. When the virtual keyboard is invoked for display in the same region, the underlying graphical user interface is redrawn with a further user interface element corresponding to at least one of the user interface elements previously displayed in the first region, so that the further user interface element is actuatable to invoke a command to carry out the corresponding function. In another embodiment, the virtual keyboard may be modified instead to provide an action key corresponding to a function related to an application executing on the device.

Abstract: The present application provides a filtration system for a gas turbine engine. The filtration system may include a holding frame with a positioning element extending therefrom and a filtration unit for mounting within the holding frame. The filtration unit may include a positioning slot therein such that the positioning element extends through the positioning slot when the filtration unit is mounted within the holding frame.

Abstract: Systems and methods for motion capture of a subject, suitable for use in an underground mining environment.