Patents by Inventor Paul Stroobant

Paul Stroobant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glial mitogenic factors, their preparation and use
    Patent number: 6147190
    Abstract: Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 14, 2000
    Assignees: Cambridge NeuroScience, Inc., Ludwig Institute for Cancer Research
    Inventors: Andrew Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchioni, Mario Su Chen, Ian Hiles
  • Glial mitogenic factors, their preparation and use
    Patent number: 5854220
    Abstract: Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells.
    Type: Grant
    Filed: October 22, 1996
    Date of Patent: December 29, 1998
    Assignees: Cambridge NeuroScience, Inc., Ludwig Institute for Cancer Research
    Inventors: Andrew Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchioni, Mario Su Chen, Ian Hiles
  • Glial mitogenic factors, their preparation and use
    Patent number: 5792849
    Abstract: Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 11, 1998
    Assignees: Ludwig Institute for Cancer Research and Cambridge NeuroScience, Cambridge NeuroScience
    Inventors: Andrew Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchioni, Mario Su Chen, Ian Hiles
  • Glial growth factors
    Patent number: 5716930
    Abstract: The invention involves secretable glial growth factors.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: February 10, 1998
    Assignees: Ludwig Institute for Cancer Research, Cambridge Neuroscience
    Inventors: Andrew David Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchionni, Maio Su Chen, Ian Hiles
  • Glial mitogenic factors
    Patent number: 5621081
    Abstract: The invention is concerned with new glial growth factors, such as the molecule referred to as GGF2. These factors are mitogenic factors for, e.g., Schwann cells.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 15, 1997
    Assignees: Ludwig Institute for Cancer Research, Cambridge Neuroscience
    Inventors: Andrew Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchioni, Mario S. Chen, Ian Hiles
  • Process for preparing glial mitogenic factors
    Patent number: 5606032
    Abstract: The invention involves the purification of various glial mitogenic factors. In one aspect of the invention, vertebrate brain material is extracted, and the extract is then subjected to chromatographic separation. The glial mitogenic factors which can be obtained include a basic polypeptide with a molecular weight of from about 30 to about 36 kD, by reference to SDS-PAGE, and a second basic polypeptide factor which is from about 55 to about 63 kD as determined by SDS-page.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 25, 1997
    Assignees: Ludwig Institute for Cancer Research, Cambridge Neuroscience
    Inventors: Andrew Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchioni, Mario S. Chen, Ian Hiles
  • Method of using a secretable glial mitogenic factor to induce acetylcholine receptor synthesis
    Patent number: 5602096
    Abstract: Disclosed is the characterization and purification of DNA encoding numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells. The present invention is specifically directed to a method of using a secretable glial growth factor to induce acetycholine receptor synthesis.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 11, 1997
    Assignees: Ludwig Institute for Cancer Research, Cambridge Neuroscience Research Inc.
    Inventors: Andrew Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchioni, Mario S. Chen, Ian Hiles
  • Schwann cell mitogenic factor, its preparation and use
    Patent number: 5594114
    Abstract: The invention provides a new Schwann cell-mitogenic factor of molecular weight about 43 to 45 kilodaltons, when isolated by SDS-PAGE. The invention provides therapeutic formulation comprising the new factor, and the use of the factor and the said formulations in treating conditions which involve a factor-sensitive or factor-responsive cell type.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: January 14, 1997
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Andrew D. J. Goodearl, Paul Stroobant, Michael D. Waterfield
  • DNA encoding glial mitogenic factors
    Patent number: 5530109
    Abstract: The invention relates to isolated nucleic acid molecules which encode for part or all of glial growth factor molecules, as well as recombinant vectors and transfected cell lines.
    Type: Grant
    Filed: March 24, 1993
    Date of Patent: June 25, 1996
    Assignees: Ludwig Institute For Cancer Research, Cambridge Neuroscience
    Inventors: Andrew Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchioni, Mario S. Chen, Ian Hiles