Abstract: The present disclosure relates methods for treating skin disorders caused by an immune deficiency with topical formulations comprising ethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (Compound I) or pharmaceutically acceptable derivative thereof. In particular, the topical formulations described herein may be used to treat atopic dermatitis, alopecia areata, or vitiligo.

Abstract: A pouched product adapted for release of a releasable component therefrom is provided herein. The pouched product can include a water-permeable fabric pouch formed so as to define a cavity therein, and a composition contained within the cavity of the water-permeable fabric pouch, the composition including one or more releasable components that are released from the composition under mouth conditions and that are capable of movement through the water-permeable fabric pouch. The composition includes nicotine and at least one particulate non-tobacco material. The pouched product also includes at least one capsule contained within the cavity of the water-permeable fabric pouch, the capsule having a capsule wall surrounding an inner payload comprising at least one botanical.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: A computer-implemented method, computer program product, and computer system for accessing content on a web page. The method accesses a displayed web page in a web browser of a user computing device and receives a search term for content within the web page. The method accesses contextual information held locally on the user computing device and scans the web page to identify one or more portions of content of the web page relevant to the search term and the contextual information. The method provides a display on the user computing device with links to the relevant web page content.

Abstract: The present invention relates to a cannabinoid derivative as a pharmaceutically active compound and method of preparation thereof. The cannabinoid derivative of the invention is an analogue of cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the cannabinoid derivative of the invention.

Abstract: The present invention relates to a group of novel compounds, methods for their manufacture and the use of these compounds as research tools and as pharmaceuticals. The novel compounds are analogues of cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of novel cannabidiol compounds.

Abstract: The present disclosure provides filter materials adapted for use as a filter element in an aerosol delivery device and methods of forming such filter materials suitable for use as a filter element in such devices. The disclosure provides, in some embodiments, a filter material which includes a plurality of fibers selected from the group consisting of regenerated cellulose, hemp, sisal, esparto, kenaf, jute, flax, wood, reconstituted tobacco, and combinations thereof, wherein the filter material is in the form of a nonwoven sheet or a fibrous tow.

Abstract: A pouched product adapted for release of a releasable component therefrom is provided herein. The pouched product can include a water-permeable fabric pouch formed so as to define a cavity therein, and a composition contained within the cavity of the water-permeable fabric pouch, the composition including one or more releasable components that are released from the composition under mouth conditions and that are capable of movement through the water-permeable fabric pouch. The composition includes nicotine and at least one particulate non-tobacco material. The pouched product also includes at least one capsule contained within the cavity of the water-permeable fabric pouch, the capsule having a capsule wall surrounding an inner payload comprising at least one botanical.

Abstract: This hard top boat cover is designed for panels to fit the bow, middle, and stern section of different width and length size boats of similar design through using a “mix and match” system. This means that each section will have more than one panel that can be chosen from for a proper fit. The result is a hard-shell boat cover that can be created for different width and length boats solving the problem of having just one size cover that fits one size boat. The cover's overlap design allows it to fit several boats without interference from gunnel attachments or interior boat obstructions. The cover's design works with an adjustable bracket brace that holds the panel covers up over the boat while being held down by straps that connect it to the boat trailer. The bracket brace design can be placed on a range of gunnel widths and at locations on the gunnel that adjust to the width of the beam of the boat for a snug fit without scarring the gunnel.

Abstract: A face-gaiter mask (10; 100) includes a top seal (14; 100B), a front filter section (10A; 100A), a rear section (100D) and a neck seal (10B; 100C). In use, the front filter section (10A, 100A) is located to the front of the user's face and is configured to cover at least the user's nostrils and the user's mouth. The front filter section (10A, 100A) includes at least two fabric layers (10; 120, 120A, 120B), wherein the at least two fabric layers are configured to provide a predetermined level of filtration and resistance to airflow through the filter section (10A; 100A). The top seal (14; 100B) includes a nose detail (12), which extends from an upper edge of the front filter section (10B; 100B) and extends at least partway into the front filter section (10B; 10 100B). The neck seal (10B; 100C) includes draping fabric, which extends from the front filter section (10B; 100B), the top seal (14; 100B) and a lower edge (17; 23; 117; 123) of the neck seal (10B; 100C).

Abstract: Covers comprising a nonwoven fabric including a plurality of recycled polyester fibers, such as a plurality of staple fibers, is provided. The plurality of recycled polyester fibers may be formed from a post-consumer polyester, a post-industrial waste polyester, or a combination thereof. The covers provide desirable vapor transmission while also providing an improved hydrostatic head. The covers may be provided in a variety of configurations. Methods of forming such covers are also provided.

Abstract: A modular multiport pod missile includes a plurality of pipe sections securable together to form a conduit for transporting a fluid in a generally horizonal direction of travel, and at least one pod secured between two of the pipe sections forming the conduit. Each pod has a plurality of input ports extending radially outwardly at an angle from a perimeter of the pod. Each of the input ports is configured for connection to a high-pressure line for delivering a high-pressure fluid from a pump to the conduit. The input ports are angled such that, when connected to a high-pressure line, high-pressure fluid flowing through the input ports merges with the fluid in the conduit generally in the same direction of travel as the fluid in the conduit.

Abstract: A modular multiport pod missile includes a plurality of pipe sections securable together to form a conduit for transporting a fluid in a generally horizontal direction of travel, and at least one pod secured between two of the pipe sections forming the conduit. Each pod has a plurality of input ports extending radially outwardly at an angle from a perimeter of the pod. Each of the input ports is configured for connection to a high-pressure line for delivering a high-pressure fluid from a pump to the conduit. The input ports are angled such that, when connected to a high-pressure line, high-pressure fluid flowing through the input ports merges with the fluid in the conduit generally in the same direction of travel as the fluid in the conduit.

Abstract: The present invention provides a wood preservative formulation comprising an isothiazolone, an organic fungicidal timber decay preservative and an unsaturated carboxylic or sulphonic acid, salt or anhydride thereof. The formulations of the invention are surprisingly effective at protecting wood and other cellulosic substrates, in particular at providing prolonged protection against in-service surface staining. The invention also provides methods for treating wood and other cellulosic substrates with said formulations.

Abstract: The present invention provides compounds of formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, and, n, are as defined herein.

Abstract: The present invention provides compounds of formula (I): Formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, Y, n, R1, R2A, R2B, R3 and *1 are as defined herein.

Abstract: The present invention provides compounds of formula (I) or (Ia) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, n, R2, R3, R4, R5, and R6 are as defined herein.

Abstract: A pouched product adapted for release of a releasable component therefrom is provided herein. The pouched product can include a water-permeable fabric pouch formed so as to define a cavity therein, and a composition contained within the cavity of the water-permeable fabric pouch, the composition including one or more releasable components that are released from the composition under mouth conditions and that are capable of movement through the water-permeable fabric pouch. The composition includes nicotine and at least one particulate non-tobacco material. The pouched product also includes at least one capsule contained within the cavity of the water-permeable fabric pouch, the capsule having a capsule wall surrounding an inner payload comprising at least one botanical.

Abstract: A pouched product adapted for release of a releasable component therefrom is provided herein. The pouched product can include a water-permeable fabric pouch formed so as to define a cavity therein, and a composition contained within the cavity of the water-permeable fabric pouch, the composition including one or more releasable components that are released from the composition under mouth conditions and that are capable of movement through the water-permeable fabric pouch. The composition includes nicotine and at least one particulate non-tobacco material. The pouched product also includes at least one capsule contained within the cavity of the water-permeable fabric pouch, the capsule having a capsule wall surrounding an inner payload comprising at least one botanical.

Abstract: A pouched product adapted for release of a releasable component therefrom is provided herein. The pouched product can include a water-permeable fabric pouch formed so as to define a cavity therein, and a composition contained within the cavity of the water-permeable fabric pouch, the composition including one or more releasable components that are released from the composition under mouth conditions and that are capable of movement through the water-permeable fabric pouch. The composition includes nicotine and at least one particulate non-tobacco material. The pouched product also includes at least one capsule contained within the cavity of the water-permeable fabric pouch, the capsule having a capsule wall surrounding an inner payload comprising at least one botanical.